Differin cream for external use of 0,1% 30 g
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Active ingredients
Adapalen
Release form
Cream
Composition
Active ingredient: adapalen. Excipients: carbomer 974P (934P) - 4, 5 mg, macrogol methydextrose sesquistearate - 35, 0 mg, glycerol - 30, 0 mg, squalane natural - 60, 0 mg, methyl dextrose sesquistearat - 35, 0 mg, disodium edetate - 1 , 0 mg, methyl parahydroxybenzoate - 2, 0 mg, propyl parahydroxybenzoate - 1, 0 mg, phenoxyethanol - 5, 0 mg, cyclomethicone - 130, 0 mg, sodium hydroxide (to pH 6, 5 ± 0, 15), purified water to 1 g. Active ingredient concentration (mg): 1 mg
Pharmacological effect
Pharmacological action - anti-inflammatory, comedolytic.
Pharmacokinetics
The adapalene absorption through the skin is very low (about 4% of the applied dose). Excretion from the body occurs mainly through bile.
Indications
Acne
Contraindications
Hypersensitivity to one of the ingredients of the drug.
Precautionary measures
According to the instructions to Differin, the drug should be applied once a day before bedtime, applying it or a thin layer on the entire surface of the skin affected by acne, or pointwise. It is important to avoid Differin in the eyes and around the eyes, as well as on the mucous membranes of the nose and lips. In case of accidental ingestion of a cream or gel in the eyes or on the lips, rinse thoroughly with warm running water. When using Differin, it is not recommended to take sun baths and spend as little time as possible in the open sun. Also, before using the drug is not recommended to use cosmetics with a drying effect (soap, alcohol-containing lotions, tonics). It is best to use moisturizers for make-up, moisturizers, Panthenol, Bepanthen for dry places. Treatment with Differin can be supplemented with morning use of drugs that help reduce acne, for example, with erythromycin or clindamycin lotion.
Use during pregnancy and lactation
The use of the drug during pregnancy and breastfeeding is not recommended.
Dosage and administration
Outwardly. With a light touch, apply the cream evenly on the affected surface once a day before going to bed on clean, dry skin, avoiding the cream getting into the eyes and lips.The therapeutic effect develops after 4-8 weeks of treatment, a lasting improvement after 3 months of treatment. In some cases, due to short-term irritation of the skin, the number of applications may be reduced or the treatment suspended until the signs of irritation disappear. Repeated treatment is possible after consultation with the doctor.
Side effects
The frequency of adverse reactions is distributed in the following order: often (in 1% - 10% of cases). infrequently (in 0, 1% - 1% of cases). rarely (in 0, 01% - 0, 1% of cases). very rarely (less than 0, 01% of cases), including reports of isolated adverse events. Skin and subcutaneous fat: Often: dry skin, skin irritation, burning sensation of the skin, erythema. Infrequently: contact dermatitis, discomfort, sunburn, itching, peeling of the skin, acne. Frequency unknown (pharmacovigilance data): skin soreness, skin swelling. On the part of the organs of sight: Frequency unknown (pharmacovigilance data): eyelid irritation, eyelid itching, eyelid swelling, erythema in the eyelids. If skin irritation develops, treatment should be stopped until the irritation disappears or the frequency of application is reduced.
Overdose
Overdose is unlikely.
Interaction with other drugs
Since the drug does not interact with oxygen and is not destroyed by the action of light, it can be used with other local and systemic drugs for the treatment of acne, such as clindamycin phosphate or benzoyl peroxide (see "Special instructions").
special instructions
Avoid getting the gel or cream in the eyes, on the lips and on the mucous membranes. In case of accidental contact with the mucous membranes of the eyes, mouth or nose, rinse thoroughly with warm water. Avoid direct sunlight, as skin irritation may occur. Treatment can be continued if solar exposure is minimized (use of sunglasses and hats). The simultaneous use of cosmetics with a drying or irritating effect on the skin (for example, perfume or alcohol-containing agents) is not recommended. Adapalen, applied to the skin in the evening, can be combined with preparations for the treatment of acne, used in the morning.