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Active ingredients
Ketorolac
Release form
Pills
Composition
1 tab. Ketorolaka tromethamine 10 mg.
Pharmacological effect
NPVS, pyrrolizin-carboxylic acid derivative. It has a pronounced analgesic effect, also has anti-inflammatory and moderate antipyretic effect. The mechanism of action is associated with inhibition of the activity of COX - the main enzyme in the metabolism of arachidonic acid, which is a precursor of prostaglandins, which play a major role in the pathogenesis of inflammation, pain and fever.
Indications
For short-term relief of moderate and severe pain of various origins.
Contraindications
Erosive and ulcerative lesions of the gastrointestinal tract in the acute phase, the presence or suspicion of gastrointestinal bleeding and / or brain hemorrhage, a history of coagulation disorders, conditions with a high risk of bleeding or incomplete hemostasis, hemorrhagic diathesis, mild and marked renal impairment ( serum creatinine content more than 50 mg / l), risk of developing renal failure in hypovolemia and dehydration "aspirin triad", bronchial asthma, nasal polyps, angioedema in anamn se, preventive analgesia prior to surgery and during surgery, childhood and adolescence to 16 years, pregnancy, parturition, lactation, increased sensitivity to Ketorolac, acetylsalicylic acid and other NSAIDs.
Use during pregnancy and lactation
Contraindicated in pregnancy, during childbirth and during lactation (breastfeeding). Ketorolac is contraindicated for use as a means for sedation, supporting anesthesia and for anesthesia in obstetric practice, because under its influence may increase the duration of the first period of labor. In addition, ketorolac can inhibit uterine contractility and fetal blood circulation.
Side effects
Since the cardiovascular system: rarely - bradycardia, changes in blood pressure, heartbeat, fainting. On the part of the digestive system: possible nausea, abdominal pain, diarrhea. rarely - constipation, flatulence, a feeling of overflow of the gastrointestinal tract, vomiting, dry mouth, thirst, stomatitis, gastritis, erosive and ulcerative lesions of the gastrointestinal tract, liver function disorders.On the part of the central nervous system and peripheral nervous system: possible anxiety, headache, drowsiness. rarely - paresthesia, depression, euphoria, sleep disturbances, dizziness, changes in taste, visual disturbances, and movement disorders. On the part of the respiratory system: rarely - respiratory failure, asthma attacks. On the part of the urinary system: rarely - increased urination, oliguria, polyuria, proteinuria, hematuria, azotemia, acute renal failure. On the part of the blood coagulation system: rarely - nasal bleeding, anemia, eosinophilia, thrombocytopenia, bleeding from postoperative wounds. On the part of metabolism: possible increased sweating, swelling. rarely - oliguria, increased creatinine and / or plasma urea, hypokalemia, hyponatremia. Allergic reactions: pruritus, hemorrhagic rash are possible. in rare cases - exfoliative dermatitis, urticaria, Lyell's syndrome, Stevens-Johnson syndrome, anaphylactic shock, bronchospasm, angioedema, myalgia. Other: fever is possible. Local reactions: pain at the injection site.
special instructions
Since the cardiovascular system: rarely - bradycardia, changes in blood pressure, heartbeat, fainting. On the part of the digestive system: possible nausea, abdominal pain, diarrhea. rarely - constipation, flatulence, a feeling of overflow of the gastrointestinal tract, vomiting, dry mouth, thirst, stomatitis, gastritis, erosive and ulcerative lesions of the gastrointestinal tract, liver function disorders. On the part of the central nervous system and peripheral nervous system: possible anxiety, headache, drowsiness. rarely - paresthesia, depression, euphoria, sleep disturbances, dizziness, changes in taste, visual disturbances, and movement disorders. On the part of the respiratory system: rarely - respiratory failure, asthma attacks. On the part of the urinary system: rarely - increased urination, oliguria, polyuria, proteinuria, hematuria, azotemia, acute renal failure. On the part of the blood coagulation system: rarely - nasal bleeding, anemia, eosinophilia, thrombocytopenia, bleeding from postoperative wounds. On the part of metabolism: possible increased sweating, swelling. rarely - oliguria, increased creatinine and / or plasma urea, hypokalemia, hyponatremia.Allergic reactions: pruritus, hemorrhagic rash are possible. in rare cases - exfoliative dermatitis, urticaria, Lyell's syndrome, Stevens-Johnson syndrome, anaphylactic shock, bronchospasm, angioedema, myalgia. Other: fever is possible. Local reactions: pain at the injection site.