Ecoclav pills 500 mg + 125 mg 15 pcs
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Active ingredients
Amoxicillin + Clavulanic Acid
Release form
Pills
Composition
Amoxicillin (in the form of trihydrate) 500 mg clavulanic acid (in the form of potassium clavulanate) 125 mg Auxiliary substances: lactulose - 600 mg, crospovidone (kollidon CL) - 45 mg, croscarmellose sodium - 45 mg, talc - 12 mg, ascorbic acid - 5 mg, magnesium stearate - 13.84 mg, microcrystalline cellulose - to obtain a tablet without shell weighing 1730 mg. The composition of the film shell: a mixture for the preparation of a film coating "Insta Moystshold" (hypromellose - 54%, ethyl cellulose - 5%, diethyl phthalate - 12%, titanium dioxide - 25%, talc - 4%) - to obtain a tablet with a shell weight of 1774.3 mg.
Indications
Infectious and inflammatory diseases caused by pathogens that are susceptible to the drug: - infections of the lower respiratory tract (bronchitis, pneumonia); - infections of upper respiratory tract (sinusitis, tonsillitis, otitis media); - infections of the urogenital system and pelvic organs (pyelonephritis, pyelitis, cystitis, urethritis, bacterial prostatitis, cervicitis, salpingitis, salpingoophoritis, endometritis, bacterial vaginitis, septic abortion, soft chancre, gonorrhea); - infections of the skin and soft tissues (erysipelas, impetigo, secondarily infected dermatosis, abscess, phlegmon, wound infection); - infections of bones and joints (osteomyelitis).
Contraindications
- Hypersensitivity (including to cephalosporins and other beta-lactam antibiotics); - Infectious mononucleosis; - episodes of jaundice or abnormal liver function as a result of the use of amoxicillin / clavulanic acid in history; - chronic renal failure (CC less than 30 ml / min) for pills with a dosage of 875 mg + 125 mg. With caution, you should prescribe the drug for severe hepatic failure, gastrointestinal diseases (including with a history of colitis associated with the use of penicillins), chronic renal failure.
Dosage and administration
The drug is taken orally. The dosage regimen is set individually depending on the age and body weight of the patient, the severity of the course and localization of the infectious process, as well as the sensitivity of the pathogen. The minimum course of antibiotic therapy is from 5 days. Treatment should not be continued for more than 14 days without revising the clinical situation. Adults and children over 12 years old or with a body weight of more than 40 kg. For mild and moderate infections, 1 tab.250 mg + 125 mg 3 times / day or 1 tab. 500 mg + 125 mg 2 times / day. For severe infections or infections of the lower respiratory tract, 1 tab. 875 mg + 125 mg 2 times / day or 1 tab. 500 mg + 125 mg 3 times / day. Since pills contain the same amount of clavulanic acid (125 mg), it should be borne in mind that 2 pills of 250 mg + 125 mg are not equivalent to 1 tablet of 500 mg + 125 mg. The maximum daily dose of amoxicillin for adults and children over 12 years old is 6 g, clavulanic acid is 600 mg. In case of chronic renal failure, the dose is adjusted and the dose rate is adjusted depending on the CC: - when the CC is more than 30 ml / min, dose adjustment is not required; - with CC 10-30 ml / min: 1 tab. 250 mg + 125 mg 2 times / day (for mild and moderate infections) or 1 tab. 500 mg + 125 mg 2 times / day (for severe infections or infections of the lower respiratory tract); - when QA is less than 10 ml / min: 1 tab. 250 mg + 125 mg 1 time / day (for mild and moderate infections) or 1 tab. 500 mg + 125 mg 1 time / day (for severe infections or infections of the lower respiratory tract). Patients on hemodialysis, appoint 1 tab. 500 mg + 125 mg or 2 tab. 250 mg + 125 mg every 24 hours in combination with 1 dose during hemodialysis and 1 dose after hemodialysis, since the concentration of amoxicillin and clavulanic acid is reduced.
Side effects
The drug is well tolerated. Side effects are rare, mostly mild and transient in nature. On the part of the digestive system: nausea, vomiting, diarrhea, gastritis, stomatitis, glossitis, cholestatic jaundice, hepatitis, liver failure (often in the elderly, men, with long-term therapy), colitis (including pseudomembranous), black "hairy" tongue, darkening of the teeth enamel, increased liver transaminase activity, increased bilirubin content and alkaline phosphatase activity. On the part of the hemopoietic system: reversible increase in prothrombin time and bleeding time, thrombocytopenia, thrombocytosis, eosinophilia, leukopenia, agranulocytosis, hemolytic anemia. From the side of the central nervous system: dizziness, headache, hyperactivity, anxiety, behavior change, seizures. From the urinary system: interstitial nephritis, crystalluria, hematuria. Allergic reactions: urticaria, erythematous rash, erythema multiforme, anaphylactic shock, angioedema, exfoliative dermatitis, erythema malignant exudative erythema (Stevens-Johnson syndrome), allergic vasculitis, a syndrome, unmarried, ungenerative, unhygly, with a variety of unmericated morphoma. Other: candidiasis, development of superinfection.