Espa-lipon injection for 600mg 24ml ampoules 24ml N5
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Description
Espa-Lipon is an endogenous antioxidant that binds free radicals. By the nature of the biochemical action is close to the vitamins of group B. Participates in the regulation of lipid and carbohydrate metabolism, stimulates cholesterol metabolism, improves liver function, reduces the damaging effect on it of endogenous and exogenous toxins. Improves trophism of neurons.
Active ingredients
Thioctic acid
Pharmacological effect
Thioctic (alpha-lipoic) acid is an endogenous antioxidant. As a coenzyme of mitochondrial multienzyme complexes, it is involved in the oxidative decarboxylation of pyruvic acid and alpha keto acids. It helps to reduce the concentration of glucose in the blood and increase glycogen in the liver, as well as to overcome insulin resistance. By the nature of the biochemical action is close to the vitamins of group B. Participates in the regulation of lipid and carbohydrate metabolism, stimulates the exchange of cholesterol, improves liver function. It has a hepatoprotective, hypolipidemic, hypocholesterolemic, hypoglycemic effect. Improves trophism of neurons.
Pharmacokinetics
With the on / in the introduction of Cmax is 25-38 mcg / ml, the time to reach it is 10-11 minutes, AUC - about 5 mcg h / ml. Thioctic (alpha-lipoic) acid has the effect of "first passage" through the liver. The formation of metabolites occurs as a result of side chain oxidation and conjugation. Bioavailability - 30%. The volume of distribution is about 450 ml / kg. Thioctic (alpha-lipoic) acid and its metabolites are excreted by the kidneys (80–90%). T1 / 2 - 20–50 min. Total plasma clearance - 10-15 ml / min.
Indications
Diabetic polyneuropathy, alcoholic neuropathy.
Dosage and administration
In / in (in the form of infusions), inside, 30 minutes before meals, without chewing and washing down with a small amount of liquid. The solution for infusion is prepared from the concentrate by dilution in isotonic sodium chloride. Severe forms of diabetic or alcoholic neuropathy. Once a day, as an intravenous drip infusion, 24 ml of solution in 250 ml of isotonic sodium chloride solution (which corresponds to 600 mg of alpha-lipoic acid per day). The drug is recommended to be used within 2-4 weeks. Infusion solutions should be administered within 50 minutes.Prepared solutions must be stored in a dark place and used for a maximum of 6 hours after preparation. Next, you should switch to maintenance therapy in the form of pills at a dose of 400–600 mg / day. The minimum duration of treatment with pills is 3 months. In the absence of other appointments, it is recommended to take 1 tab. on 600 mg, or on 2–3 tab. 200 mg, which corresponds to 400-600 mg of thioctic (alpha-lipoic) acid per day. In some cases, taking the drug involves a more prolonged use, the terms of which are determined by the attending physician.