Essentiale forte N capsules 90 pcs
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Description
The drug Essentiale Forte N has a normalizing effect on the metabolism of lipids and proteins, detoxification of the liver, the restoration and preservation of the cellular structure of the liver and phospholipid-dependent enzyme systems, which ultimately prevents the formation of connective tissue in the liver and contributes to the natural regeneration of liver cells.
Active ingredients
Phospholipids
Pharmacological effect
Essential phospholipids are the main elements of the structure of the membrane of cells and cell organelles. In liver diseases there is always damage to the membranes of the liver cells and their organelles, which leads to impaired activity of the associated enzymes and receptor systems, deterioration of the functional activity of the liver cells and reduced ability to regenerate. The phospholipids that are part of Essentiale® forte H correspond to its chemical structure is endogenous phospholipids, but superior to endogenous phospholipids in activity due to their higher content of polyunsaturated (essential) fatty acids from. Embedding these high-energy molecules in the damaged parts of the cell membranes of hepatocytes restores the integrity of the liver cells and contributes to their regeneration. Cis-double bonds of their polyunsaturated fatty acids prevent parallel arrangement of hydrocarbon chains in cell membrane phospholipids, the phospholipid structure of cell membranes of hepatocytes is loosened, which increases their fluidity and elasticity, improves metabolism. The resulting functional blocks increase the activity of enzymes fixed on the membranes and contribute to the normal, physiological pathway of the most important metabolic processes. The phospholipids that are part of Essentiale® forte regulate lipoprotein metabolism, transferring neutral fats and cholesterol to oxidation sites, this is mainly due to the increase the ability of high-density lipoprotein to bind to cholesterol. Thus, the drug has a normalizing effect on metabolites m lipids and proteins detoxication liver function for the restoration and preservation of cell structure and fosfolipidozavisimyh liver enzyme systems,which ultimately prevents the formation of connective tissue in the liver and contributes to the natural regeneration of liver cells. When phospholipids are excreted in the bile, the lithogenic index decreases and bile stabilizes.
Pharmacokinetics
More than 90% of ingested phospholipids are absorbed in the small intestine. Most of them are cleaved by phospholipase A to 1-acyl-lysophosphatidylcholine, 50% of which is immediately subjected to reverse acetylation in polyunsaturated phosphatidylcholine during the process of absorption in the intestinal mucosa. This polyunsaturated phosphatidylcholine with lymph flow enters the blood and from there, mainly in a high-density form associated with lipoprotenes, enters the liver. Studies of the pharmacokinetics in humans were carried out with radioactively labeled (3H and 14C). The choline portion was labeled with 3H, and the linoleic acid residue had a 14C.Cmax 3H mark reached 6-24 hours after administration and was 19.9% of the prescribed dose. The T1 / 2 of the choline component was 66 hours. Cmax14C reached 4-12 hours. after administration and amounts to 27.9% of the prescribed dose. T1 / 2 of this component is 32 parts. Both of the isotope are more than 90% absorbed in the intestine. Excretion In feces, 2% of the administered dose of 3H and 4.5% of the administered dose of 14C are detected, in urine 6% of 3H and only a minimal amount of 14C.
Indications
- chronic hepatitis, - liver cirrhosis, - fatty liver dystrophy of various etiologies, - toxic liver damage, - alcoholic hepatitis, - liver dysfunction in other somatic diseases, - pregnancy toxicosis, - prevention of recurrence of gallstones, - psoriasis (as a means adjuvant therapy), - radiation syndrome.
Dosage and administration
Inside Capsules should be swallowed whole, drinking plenty of water (approximately 1 cup). For adolescents over 12 years old and weighing more than 43 kg, as well as for adults Essentiale Forte N, it is recommended to take 2 capsules 3 times / day during meals. As a rule , the duration of application is not limited.