Famotidine Hemofarm pills coated 20mg N30
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Active ingredients
Famotidine
Release form
Pills
Composition
Famotidine - 20 mg. Adjuvants: corn starch; MCC; silicon dioxide; talc; magnesium stearate; croscarmellose sodiumCapus: hydroxypropylmethylcellulose; macrogol 600; titanium dioxide; talc; iron oxide brown
Pharmacological effect
Anti-ulcer. Blocks histamine H2 receptors, inhibits the production of hydrochloric acid.
Pharmacokinetics
After ingestion quickly, but not completely, absorbed from the gastrointestinal tract. Cmax in plasma is reached after 2 hours. Bioavailability is 40-45% and varies slightly in the presence of food. T1 / 2 of plasma is about 3 hours and increases in patients with impaired renal function. Binding to proteins is 15-20%. A small part of the active substance is metabolized in the liver to form famotidine S-oxide. Most are excreted unchanged in the urine.
Indications
Peptic ulcer and duodenal ulcer (including prevention of exacerbations); symptomatic ulcers, erosive and reflux esophagitis; Zollinger-Ellison syndrome.
Contraindications
Hypersensitivity, pregnancy, lactation.
Use during pregnancy and lactation
It is contraindicated for use during pregnancy and lactation. Famotidine is excreted in breast milk.
Dosage and administration
Inside, swallowing whole (without chewing), drinking plenty of water. In case of gastric ulcer and duodenal ulcer in the acute phase, symptomatic ulcers, erosive gastroduodenitis - usually 20 mg 2 times a day or 40 mg 1 time a day for the night. If necessary, the daily dose may be increased to 80-160 mg. The course of treatment is 4–8 weeks. For dyspepsia associated with increased secretory function of the stomach, 20 mg 1–2 times a day. To prevent recurrence of peptic ulcer, 20 mg once a day before bedtime. When reflux esophagitis - 20–40 mg 2 times a day for 6–12 weeks. In the case of Zollinger-Ellison syndrome, the dose of the drug and the duration of the course of treatment are set individually. The initial dose is usually 20 mg every 6 hours and may be increased to 160 mg every 6 hours. To prevent aspiration of gastric juice with general anesthesia, 40 mg in the evening and / or in the morning before surgery. For renal failure (when Cl creatinine is less than 30 ml / min or serum creatinine> 3 mg / 100 ml) the daily dose of the drug should be reduced to 20 mg.
Side effects
Rarely - headache, dizziness, fatigue, dry mouth, lack of appetite, diarrhea or constipation, skin rash.
Interaction with other drugs
Antacids violate absorption (a break between taking antacids and famotidine is recommended for at least 1–2 h).
special instructions
It is used with caution in patients with impaired renal and hepatic function. Before starting treatment, it is necessary to exclude the possibility of a malignant disease of the esophagus, stomach or duodenum. Clinical experience with famotidine in children is limited.