Finalgon ointment for external use of 20 g
Condition: New product
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Active ingredients
Nonivamid + Nikoboksil
Release form
Ointment
Composition
Active ingredient: Nonivamid + Nicoboxyl * (Nonivamidum + Nicoboxilum) Concentration of the active ingredient (mg): Nonivamid (nonylic acid vanillilide) (PSVA) 4 mg, nicoboxyl (nicotinic acid butoxyethyl ester) (NSBE) 25 mg
Pharmacological effect
Nonivamide is a synthetic analogue of capsaicin and has analgesic properties, which manifest themselves as a result of the gradual penetration of the active substance into the peripheral nociceptive C-fibers and A-delta nerve fibers upon repeated application of the drug to the skin. Nonivamide has a vasodilating effect, which is accompanied by an intense, long-lasting sensation of heat, due to the stimulation of afferent nerve endings in the skin. Nicoboxyl is a derivative of nicotinic acid, which has vasodilating properties with the participation of prostaglandins I2 and E2. The hyperemic effect of nicoboxil (nicotinic acid butoxyethyl ester) develops faster and has greater intensity than the hyperemic effect of nonivamide. skin within a few minutes after application indicate rapid penetration of the active components of the prep paratus shown in kozhu.Deystvie finalgon locally develops within a few minutes and reaches its maximum after 20-30 min.Analgeziruyuschee effect of the combination of 0.4% and 2.5% nonivamide nikoboksila been demonstrated in the study of efficacy in patients with acute nonspecific pain in the lower back. It was found that patients who used the drug Finalgon (2 cm of ointment per application up to 3 times / day for 4 days) showed a clinically significant decrease in the intensity of pain in the lower back after 4 hours after the first application; a clinically significant reduction in pain was also observed on the last day of treatment, determined individually. In a clinical study, it was established that the decrease in pain began after 1-2 hours.
Pharmacokinetics
Data on the pharmacokinetics of the drug Finalgon not provided.
Indications
Arthritis, rheumatic pain in the joints and muscles, sports injuries, bruises and injuries of the ligaments, muscle pain caused by excessive physical exertion, lumbago, neuritis, sciatica, bursitis and tendovaginitis. For preliminary "warming up" of muscles before exercise, sports competitions. As part of a complex vasodilator therapy for disorders of peripheral circulation.
Contraindications
Hypersensitivity to nikoboksil, nonivamid or excipients of the drug. Ointment should not be applied to sensitive skin, open wounds, inflamed skin areas, skin areas with increased permeability: neck, lower abdomen, inner side of thighs. Children under 12 years of age.
Precautionary measures
The drug should not be applied to sensitive skin, open wounds, inflamed skin, areas of skin with increased permeability: neck, lower abdomen, inner side of thighs.
Use during pregnancy and lactation
The drug causes flushing of the skin, resulting in redness, sensation of heat, itching and burning at the site of use. These symptoms may be more pronounced when applying an excess amount of the drug or in case of intense rubbing on the skin surface. Using excessive amounts of the drug or intensive rubbing on the skin surface can lead to the appearance of vesicles or pustules at the site of application of the ointment. After using the Finalgon product, wash your hands with soap and water immediately. Care should be taken to avoid accidental contact with the other skin or other products Avoid accidental contact with the face, eyes, nose or mouth. This can lead to temporary swelling of the face, pain in the face, inflammation of the conjunctiva, eye flushes, burning eyes, impaired vision, discomfort in the mouth and stomatitis. or application of heat to the site of application of the drug may cause redness of the skin and an intense sensation of heat even several hours after the application of Finalgon. The preparation contains sorbic acid, which can cause local skin irritation (eg imercontact dermatitis). Impact on the ability to drive motor vehicles and control mechanismsSpecial clinical studies of the effect of the drug on the ability to drive and mechanisms have not been conducted. However, caution should be exercised when using the drug while driving and working with mechanisms.
Dosage and administration
Treatment must begin with applying a small amount of the drug to a small area of skin to evaluate an individual reaction. An individual reaction to the drug may differ significantly: some people will only need to apply a small amount of ointment to cause the necessary warming effect. With the help of the attached applicator, a column of the drug no more than 0.5 cm, applied to the corresponding skin area the size of a palm with light rubbing movements. To enhance the therapeutic effect of the skin on which the drug is applied, you can cover with woolen cloth. With repeated use, the reaction to the ointment may be reduced, which requires an increase in dose, which is selected individually. If necessary, the ointment is used 2-3 times a day. For preheating the muscles before exercise, sports competitions should be rubbed about 30 minutes before they start. If you do not have the desired effect, you should contact a specialist for 10 days. After applying the drug to the skin wash hands thoroughly with soap and water.
Overdose
Side Effects During the long experience with the drug, the following side effects were revealed: Immune system: anaphylactic reactions, hypersensitivity. On the nervous system: paresthesia, burning sensation of the skin. On the respiratory organs: cough, shortness of breath. On the side of the skin and subcutaneous tissues : vesicles or pustules at the site of application, local skin reaction (for example, contact dermatitis), itching, rash, swelling of the face, urticaria, sensation of heat at the site of application.
Interaction with other drugs
Drug interaction of the drug Finalgon with other drugs used topically or systemically, was not detected.
special instructions
Symptoms: The effect of skin hyperemia and the severity of dose-dependent side effects may be exacerbated after applying an excessive amount of Finalgon ointment.The use of excessive amounts of the drug can lead to the appearance of vesicles or pustules at the site of application of the ointment. An overdose of the drug can cause systemic reactions (redness of the upper body, increased body temperature, blood flow, painful hyperemia, decrease in blood pressure), because nicotinic acid esters have good transdermal absorption. Treatment: when using an excess amount of the drug, the effect can be reduced if you remove the ointment from the skin surface with vegetable oil or cosmetic cream on a fatty basis, from the eye mucosa (in case of accidental contact) - with the help of medical vaseline If necessary, symptomatic treatment should be carried out.