Flagyl vaginal suppositories 500mg N10
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Active ingredients
Metronidazole
Release form
Suppositories
Composition
Active ingredient: Metronidazole (Metronidazolum) Active ingredient concentration (mg): 500
Pharmacological effect
Metronidazole refers to nitro-5-imidazoles. The mechanism of action of metronidazole is the biochemical reduction of the 5-nitro group of metronidazole by intracellular transport proteins of anaerobic microorganisms and protozoa. The recovered 5-nitro group of metronidazole interacts with the microbial cell DNA, inhibiting the synthesis of their nucleic acids, which leads to the death of microorganisms. Metronidazole is an effective antimicrobial and antiprotozoal agent of a broad spectrum of action. The drug exhibits high activity against Trichomonas vaginalis, Giardia intestinalis, Entamoeba histolytica, Lamblia intestinalis, as well as with respect to obligate anaerobes (spore-and non-sporogenous) - Bacteroides spp. (B.fragilis, B.ovatus, B.distasonis, B.thetaiotaomicron, B.vulgatus), Fusobacterium spp., Clostridium spp., Peptostreptococcus spp., Peptococcus spp., Susceptible Eubacterium strains. anaerobes
Pharmacokinetics
Approximately 20% of the applied dose of metronidazole (500 mg) is subjected to systemic absorption, as a result of which the drug concentration in the blood plasma is approximately 12% of that after oral administration of a single dose of 500 mg T1 / 2 (the clearance established for systemic use in normal liver function) is 8-10 hours. Communication with plasma proteins is less than 20%.
Indications
- local treatment of trichomonas and nonspecific vaginitis; - prevention of the occurrence of anaerobic infections during surgical interventions on the organs of the abdominal cavity and small pelvis.
Contraindications
- organic lesions of the central nervous system (including epilepsy); - loss of coordination of movements; - blood diseases (including leukopenia in history); - liver failure (in the case of large doses); - pregnancy; - breastfeeding; - hypersensitivity to imidazoles, as well as to nitroimidazole derivatives.
Precautionary measures
Do not exceed recommended doses.
Use during pregnancy and lactation
Contraindications: pregnancy and breastfeeding.
Dosage and administration
The drug is used only in adults. Adults Trichomonas vaginitis: 1 suppository per day in the vagina, for 10 days in combination with the drug metronidazole, pills inside. Non-specific vaginitis: 1 suppository 2 times / day for 7 days, if necessary in combination with the drug metronidazole, pills inside.It is imperative that simultaneous treatment of the sexual partner with metronidazole, regardless of whether it has any manifestations of the disease. Metronidazole treatment should not be prescribed for more than 10 days, and repeated more than 2-3 times a year. After freeing the suppository from the contour package with using scissors, cut the film along the contour of the suppository and insert it deep into the vagina.
Side effects
On the part of the gastrointestinal tract: nausea, metallic taste in the mouth, dry mouth, loss of appetite, glossitis, stomatitis, pancreatitis, anorexia, epigastric pain, vomiting, diarrhea, constipation. On the nervous system: headache, dizziness, poor coordination of movements, ataxia, confusion, irritability, depression, irritability, weakness, insomnia, convulsions, confusion, hallucinations, peripheral neuropathy (especially with prolonged use). Allergic reactions: urticaria, skin rash, skin flushing, s nasal congestion, fever, arthralgia. From the urinary system: dysuria, polyuria, cystitis, urinary incontinence, candidiasis, brownish-reddish color of urine may be present. Local reactions: burning sensation or irritation of the penis in the sexual partner, burning sensation or frequent urination , vulvitis (itching, burning pain or hyperemia of the mucous membrane in the region of the external genital organs). Other: neutropenia, leukopenia, flattening of the T wave on the ECG. After discontinuation of the drug may develop vaginal candidiasis.
Overdose
No data.
Interaction with other drugs
Similarly, disulfiram causes intolerance to ethanol. Simultaneous use with disulfiram can lead to the development of various neurological symptoms (the interval between administration is not less than 2 weeks). It exacerbates the effect of indirect anticoagulants, which leads to an increase in the time of formation of prothrombin. the concentration of the latter in plasma. When taken simultaneously with cyclosporin, the concentration of the latter in plasma may increase. Cimetidine inhibits the metabolism of metronide ol, which could lead to an increase in blood serum concentration and increased risk of adverse yavleniy.Odnovremennoe prescribing,stimulating microsomal oxidation enzymes in the liver (phenobarbital, phenytoin), can accelerate the elimination of metronidazole, resulting in a decrease in plasma concentration. Metronidazole reduces the clearance of 5-fluorouracil, leading to an increase in its toxicity. its toxicity (severe form). It is not recommended to combine with non-depolarizing muscle relaxants (vecuronium bromide).
special instructions
Since the simultaneous intake of the drug with alcohol can have an effect similar to that of disulfiram (fever, vomiting, tachycardia), patients should be warned that during treatment with flagelome they should not drink alcoholic beverages or drugs containing alcohol. control blood count. In case of leukopenia, the possibility of continuing treatment depends on the risk of developing an infectious process. When treating Trichomonas vaginitis in women, it is necessary to refrain from sexual activity. Necessarily simultaneous treatment of sexual partners. The treatment does not stop during menstruation. After treatment of trichomoniasis, control tests should be carried out for 3 consecutive cycles before and after menstruation. Treatment should be stopped when ataxia appears, dizziness, hallucinations develop, and the neurological status of patients worsens. It is necessary to take into account that metronidazole can immobilize treponema, which leads to Nelson’s test. Influence on the ability to drive a car and other mechanisms In connection with the possibility of dizziness and other side effects associated taking the drug, it is recommended to refrain from driving and other mechanisms.