Foradil capsules powder for inhalation 12mcg dose N60
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Active ingredients
Formoterol
Release form
Capsules
Composition
Active ingredient: Formoterol (formoterol) Active ingredient concentration (mg): 12 mcg
Pharmacological effect
Beta adrenomimetic. acts primarily on β2-adrenoreceptors. has a bronchodilator effect, suppresses and warns of bronchospasm. inhibits the release of histamine, leukotrienes and prostaglandin d2 from mast cells, basophils and sensitized cells of the bronchoalveolar tree.
Pharmacokinetics
With inhalation, about 90% of the active substance may be swallowed. When ingestion is rapidly absorbed from the gastrointestinal tract. Absorption is 65%. Cmax is achieved in 0.5–1 h. Plasma protein binding is 61–64%. T1 / 2 - 2-3 hours. Metabolized mainly by glucuronization. Excreted by the kidneys (70%) and through the intestines (30%). Renal clearance is 150 ml / min. When administered by inhalation, it is rapidly absorbed, Cmax is reached after 15 minutes, the concentration of the active substance in the lungs after inhalation using a turbuhaler is 21-37%. Bioavailability - 46%. Plasma protein binding - 50%. T1 / 2 - 8 h.
Indications
Prevention and treatment of bronchospasm in patients with obstructive bronchitis, bronchial asthma.
Contraindications
Hypersensitivity to formoterol or other beta-adrenomimetics, children under 5 years old.
Precautionary measures
Keep out of the reach of children.
Use during pregnancy and lactation
During pregnancy and lactation, formoterol is used with caution, only in cases where the expected therapeutic effect for the mother outweighs the potential risk of side effects for the fetus or child.
Dosage and administration
Apply in the form of inhalation. The dose depends on the dosage form used and the age of the patient.
Side effects
Possible: headache, nausea, dry mouth, tremor. Rare: muscle cramps, myalgia, tachycardia, dizziness, agitation, anxiety, sleep disorders, nervousness, increased bronchospasm. In some cases: hypersensitivity reactions (severe hypotension, urticaria, angioedema, pruritus, rash), peripheral edema, change in taste.
Interaction with other drugs
Formoterol should not be combined with adrenomimetic agents, MAO inhibitors, tricyclic antidepressants (the risk of side effects from the cardiovascular system increases). With simultaneous use, xanthine derivatives, GCS, diuretics increase the likelihood of a hypocaliemic effect of the drug. , phenothiazines, antihistamines, tricyclic antidepressants increase the risk of ventricular arrhythmias. Beta-blocker (Including in the form of eye drops) is partially or completely block the action of formoterol.
special instructions
Special care and careful observation is required if you need to use formoterol in patients with the following comorbidities: IHD; heart rhythm and conduction disturbances, especially AV degree III blockade; severe heart failure; idiopathic subvalvular aortic stenosis; hypertrophic obstructive cardiomyopathy; thyrotoxicosis; known or suspected lengthening of the QT interval (QT adjusted> 0.44 s). It is used with caution in patients with diabetes mellitus, uterine myoma. Effects on the ability to drive vehicles and control mechanismsTremor or anxiety that occur during treatment with beta-adrenostimulyatory, can affect the ability patient to drive a car, so when applying formoterol it is not recommended to engage in potentially hazardous activities that require increased attention, quick psychomotor reactions.