Indomethacin ointment 10% 40g
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Active ingredients
Indomethacin
Release form
Ointment
Composition
in 100 g ointment: active substance: indomethacin 10 hv adjuvants: lanolin - 17.5 g; petrolatum - 52.45 g; dimethyl sulfoxide - 15 g; beeswax yellow - 2 g; colloidal silicon dioxide - 3 g; lavender oil - 0.05 g
Pharmacological effect
It has anti-inflammatory and analgesic effects due to inhibition of cyclooxygenase-2 (COX-2), which regulates the synthesis of pro-inflammatory prostaglandins.
Indications
Rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, gouty arthritis, psoriatic arthritis, osteochondrosis with radicular syndrome. Traumatic inflammation of the soft tissues and the musculoskeletal system (sprains, dislocations, bruises). Neuralgia and myalgia of various genesis. The drug is indicated for symptomatic therapy, reduction of pain and inflammation at the time of use, it does not affect the progression of the disease.
Contraindications
Joint syndrome (rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, gout); Traumatic inflammation of soft tissues and musculoskeletal system; Neuralgia, myalgia; The drug is intended for symptomatic therapy, reduction of pain and inflammation, does not affect the progression of the disease.
Dosage and administration
externally, the ointment is rubbed in light movements, in a thin layer into the skin of painful areas of the body, 2 to 3 cm (1 to 1.5 g.) 2 to 3 times a day. The total number for adults per day should not exceed 15 cm., Squeezed out of the tube, for children over 14 years old - 7.5 cm. The duration of treatment should not exceed 10 days.
Side effects
Local reactions: eczema, photosensitivity, contact dermatitis (itching, redness, swelling of the treated skin area, papules, vesicles, peeling). Systemic reactions: generalized skin rash, allergic reactions (urticaria
Overdose
Extremely low systemic absorption of the active ingredients of the drug when applied topically makes overdosing almost impossible. However, if you accidentally use large amounts of ointment, undesirable reactions may occur: nausea, vomiting, severe headache, dizziness, memory impairment and disorientation.In more severe cases, paresthesia, numbness of the extremities and convulsions are observed. If random quantities of the drug are swallowed, systemic side effects may develop. The treatment includes the rapid elimination of the drug from the body and the use of appropriate symptomatic agents. Indomethacin cannot be excreted through hemodialysis.
Interaction with other drugs
The effect of Indomethacin is enhanced by its combination with glucocorticosteroids and pyrazolone derivatives. May enhance the effect of drugs that cause photosensitivity.
special instructions
Ointment should be applied only to intact skin, avoid contact with eyes or mucous membranes.