Itrazole capsules 100mg N42
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Active ingredients
Itraconazole
Composition
Itraconazole (in the form of pellets) 100 mg Auxiliary substances: sugar pellets (sucrose - 80-91.5%, corn starch - 8.5-20%) - 207.44 mg, poloxamer 188 (Lutrol) - 25.94 mg, poloxamer 188 (Lutrol) micronized - 0.51 mg, hypromellose - 130.11 mg. The composition of hard gelatin capsules: titanium dioxide - 2%, gelatin - up to 100%. Capsule weight with contents - 560 mg.
Pharmacological effect
Antifungal medication. Itraconazole is a broad-spectrum synthetic antifungal agent derived from triazole. Inhibits the synthesis of ergosterol in the cell membrane of fungi, which causes the antifungal effect of the drug. Itraconazole is active against infections caused by dermatophytes (Trichophyton spp., Microsporum spp., Epidermophyton floccosum), yeast-like fungi and yeast (Cryptococcus neoformans, Pityrosporum spp., Candida spp., Including Candida albicans, a category of a number of ages of a number of cases, and the use of a number of countries, which have come to the edema of the infections, infections caused by infections caused by dermatophytes ., Histoplasma spp., Paracoccidioides brasiliensis, Sporothrix schenckii, Fonsecaea spp., Cladosporium spp., Blastomyces dermatidis, as well as other yeast and mold fungi.
Indications
Dermatomycosis. fungal keratitis. onychomycosis caused by dermatophytes and / or yeast and mold fungi. Systemic mycoses: systemic aspergillosis and candidiasis, cryptococcosis (including crypto, coccal meningitis), histoplasmosis, sporotrichosis, paracoccidioidomycosis, blastomycosis and other systemic or tropical mycoses. Candidomycosis with damage to the skin or mucous membranes, including vulvovaginal candidiasis. pityriasis versicolor.
Contraindications
Individual hypersensitivity to the drug or its constituent parts. concomitant medication, metabolized with the participation of the enzyme CYP3A4: terfenadine, astemizol, mizolastin, cisapride, dofetilide, quinidine, pimozide, reagent inhibitors of MMC - CoA, such as simvastatin and lovastatin, triazolam and midazolam "). children's age up to 3 years. pregnancy lactation period.
Use during pregnancy and lactation
The drug is contraindicated for use during pregnancy and lactation (breastfeeding). Women of childbearing age, taking Itrazole, you must use adequate methods of contraception throughout the course of treatment until the first menstruation after its completion.
Dosage and administration
Inside, after eating.
Side effects
On the part of the gastrointestinal tract: dyspepsia, nausea, abdominal pain and constipation, reversible increase in liver enzymes, cholestatic jaundice, hepatitis, anorexia.In very rare cases with the use of Itrazole, severe toxic liver damage developed, including a case of fatal liver failure. Co side of the central nervous system: headache, fatigue, dizziness, peripheral neuropathy. Since the cardiovascular system: congestive heart failure and pulmonary edema. From other organs and systems: menstrual disorders, allergic reactions (such as itching, rash, urticaria, and angioedema), Stevens-Johnson syndrome, alopecia, hypokalemia, edema, dark-colored urine staining, gilercreatininemia.
special instructions
On the part of the gastrointestinal tract: dyspepsia, nausea, abdominal pain and constipation, reversible increase in liver enzymes, cholestatic jaundice, hepatitis, anorexia. In very rare cases with the use of Itrazole, severe toxic liver damage developed, including a case of fatal liver failure. Co side of the central nervous system: headache, fatigue, dizziness, peripheral neuropathy. Since the cardiovascular system: congestive heart failure and pulmonary edema. From other organs and systems: menstrual disorders, allergic reactions (such as itching, rash, urticaria, and angioedema), Stevens-Johnson syndrome, alopecia, hypokalemia, edema, dark-colored urine staining, gilercreatininemia.