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Active ingredients
Bromhexine + Guaifenezin + Salbutamol + Levomenthol
Release form
Syrup
Composition
Salbutamol sulphate 1.205 mg, which corresponds to the content of salbutamol 1 mg, bromhexine hydrochloride 3 acid monohydrate, sorbitol (non-crystallizing) liquid, sunset yellow dye, purified water.
Pharmacological effect
The combined drug has a bronchodilator, expectorant, mucolytic action. Salbutamol is a bronchodilator, stimulates the β2-adrenoreceptors of the bronchi, warns or stops bronchospasm. Bromhexine is a mucolytic agent, has expectorant and weak antitussive effect. Reduces the viscosity of sputum due to the depolarization of acid mucopolysaccharides and stimulation of the secretory cells of the bronchial mucosa. It activates the cilia of the ciliated epithelium, improving sputum discharge. Gvayfenezin - reduces surface tension and adhesive properties of sputum, increases the serous component of bronchial secretions, reduces the viscosity of sputum, activates the ciliary apparatus of the bronchi, facilitates the removal of sputum and promotes the transition of non-productive cough into productive. Menthol has a spasmolytic effect, gently stimulates the secretion of bronchial glands, has antiseptic properties, has a calming effect and reduces irritation of the respiratory tract mucosa.
Pharmacokinetics
Information about the pharmacokinetics of the drug is not provided.
Indications
Acute and chronic bronchopulmonary diseases, accompanied by difficulty in sputum discharge: - bronchial asthma; - chronic bronchitis; - pulmonary emphysema; - COPD; - tracheobronchitis; - pneumonia; - pneumoconiosis; - pulmonary tuberculosis.
Contraindications
- tachyarrhythmia; - myocarditis; - aortic stenosis; - decompensated diabetes; - thyrotoxicosis; - glaucoma; - hepatic and / or renal failure; - peptic ulcer of the stomach and duodenal ulcer in the phase of exacerbation; - gastric bleeding; - pregnancy; (breastfeeding); - hypersensitivity to the drug components.; The drug should be used with caution in diabetes mellitus, arterial hypertension,a history of gastric ulcer and duodenal ulcer along with antitussive agents, non-selective β-adrenoreceptor blockers, MAO inhibitors.
Dosage and administration
The drug should be taken orally. Children under the age of 6 years - 1 tsp. (5 ml) 3 times / day; from 6 to 12 years old - 1-2 tsp. (5-10 ml) 3 times / day. Adults and children over 12 years old - 2 tsp. (10 ml) 3 times / day.