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Active ingredients
Ketoprofen
Release form
Gel
Pharmacological effect
Ingredients1 gketoprofen 25 mg [Excipients: (carbomer - 20 mg, trolamine (triethanolamine) - 37 mg, ethanol 96% - 285 mg, lavender oil (lavender essential oil) - 0.28 mg, water - 632.72 mg) - 1 g.
Indications
Pharmacokinetics Absorption Ketoprofen is absorbed very slowly and practically does not accumulate in the body. Bioavailability is 5%. Ketoprofen penetrates into the synovial fluid and reaches therapeutic concentrations there. The concentration of the drug in the blood plasma is extremely low. Metabolism and elimination of Ketoprofen is metabolized in the liver to form conjugates that are mainly excreted in the urine. Ketoprofen is characterized by slow urine excretion. The pharmacokinetics in special clinical situations of ketoprofen does not depend on the age, the degree of renal failure, or liver cirrhosis.
Contraindications
NSAIDs. It has analgesic, anti-inflammatory and anti-edema effect. Inhibits the activity of COX, which leads to inhibition of prostaglandin synthesis. In addition, ketoprofen inhibits lipoxygenase, the synthesis of bradykinin, stabilizes lysosomal membranes and prevents the release of enzymes involved in the inflammatory process. Ketoprofen does not adversely affect the condition of the articular cartilage.
Use during pregnancy and lactation
Symptomatic therapy of painful and inflammatory processes of various origins, including: - rheumatoid arthritis and periarthritis; - ankylosing spondylitis (Bechterew's disease); - psoriatic arthritis; - reactive arthritis (Reiter syndrome); - osteoarthritis of different localization; - tendinitis, bursitis - myalgia; - neuralgia; - radiculitis; - injuries of the musculoskeletal system (including sports), bruises of the muscles and ligaments, sprains, ruptures of the ligaments and tendons of the muscles.