Lamisil spray for external use 30 ml
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Active ingredients
Terbinafin
Release form
Spray
Composition
Active ingredient: terbinafine Concentration of active ingredient (mg): 10 mg
Pharmacological effect
Antifungal drug for external use, with a wide range of antifungal activity. In small concentrations, terbinafine has a fungicidal effect against dermatophytes (Trychophyton rubrum, Trychophyton mentagrophytes, Trychophyton verrucosum, Trychophyton violaceum, Trychophyton tonsurans, Microsporum canis, Epidermophyton floccosum), mold (mainly Candida albicus paints, iaaaaaaaaaaaaaaaaa), which are not enough to use (I do not need to, I’ll see how I’m like, I’ll see how I’m going to get to get to the age of Activity against yeast fungi, depending on their species, can be fungicidal or fungistatic. Terbinafine specifically changes the early stage of sterol biosynthesis that occurs in fungi. This leads to a deficiency of ergosterol and to the intracellular accumulation of squalene, which causes the death of the fungal cell. The action of terbinafine is carried out by inhibiting the enzyme squalene epoxidase, located on the cell membrane of the fungus. Terbinafine does not affect the cytochrome P450 system in humans and, accordingly, the metabolism of hormones or other drugs.
Pharmacokinetics
When applied topically, absorption of less than 5% has a slight systemic effect.
Indications
Prevention and treatment of fungal infections of the skin, including foot mycoses (“fungus” of the foot), athlete's groin (tinea cruris), fungal lesions of smooth skin of the body (tinea corporis) caused by dermatophytes such as Trichophyton (including T. rubrum , T. mentagrophytes, T. verrucosum, T. violaceum), Microsporum canis and Epidermophyton floccosum. Pityriasis versicolor, caused by Pityrosporum orbiculare (also known as Malassezia furfur).
Contraindications
Hypersensitivity to terbinafine or to any of the inactive ingredients that make up the drug.
Precautionary measures
Do not exceed the recommended dose. With caution, the drug is prescribed to patients with hepatic and / or renal failure, patients with chronic alcoholism, in the suppression of bone marrow hematopoiesis, tumors, metabolic diseases, occlusive vascular diseases of the extremities.
Use during pregnancy and lactation
Since the clinical experience with Lamisil cream in pregnant women is very limited, it should not be used, unless absolutely necessary. In pregnancy, the drug is used only if the intended benefit to the mother outweighs the potential risk to the fetus.It is necessary to consult a doctor. In experimental studies of the teratogenic properties of terbinafine were not identified. To date, no developmental defects have been reported with Lamisil. Terbinafine is excreted in breast milk, so the drug should not be given to nursing mothers. The infant should not be allowed to contact any surface of the skin treated with Lamisil.
Dosage and administration
Outwardly. Adults. Lamisil spray or solution can be applied 1 or 2 times a day, depending on the evidence. Before using the drug, it is necessary to thoroughly clean and dry the affected areas. The drug is sprayed (spray) or applied (solution) to the affected areas in an amount sufficient to thoroughly moisturize it, and, in addition, applied to the adjacent areas of both the affected and intact skin. In case of extensive fungal infections of the body, a spray of 30 ml is recommended. Duration of treatment and frequency of use of the drug: ringworm of the body, legs: 1 week; 1 time per day pediatric foot stop: 1 week; Once a day lichen colored: 1 week; 2 times a day. The dosing regimen of lamisil spray or solution in the elderly does not differ from the above. The use of Lamisil spray or solution in children. Experience with Lamisil spray or solution in children is limited, and therefore the use of the drug in children is not recommended.
Side effects
In places of application of the drug may appear redness, itching or burning. Allergic reactions.
Overdose
No cases of Lamisil overdose have been reported. Symptoms: random intake of 30 ml of Lamisil spray containing 300 mg of terbinafine hydrochloride is comparable to taking 1 tablet of Lamisil 250 mg (single dose for an adult). If you take a larger amount of Lamisil spray by mouth, you can expect the development of the same side effects as with an overdose of Lamisil pills (headache, nausea, epigastric pain and dizziness). It should also be borne in mind that the spray contains ethyl alcohol (28.87% (v / v). Treatment: activated carbon, if necessary, symptomatic therapy is carried out.
Interaction with other drugs
Currently, the drug interaction of the drug Lamisil is unknown.
special instructions
Reducing the severity of clinical manifestations is usually observed in the first days of treatment. In the case of irregular use or premature termination of it, there is a risk of recurrence of the infection. It may cause irritation. In case of accidental contact with eyes, rinse immediately with running water, and if persistent irritation develops, you should consult a doctor. If allergic reactions develop, the drug should be withdrawn. (contact dermatitis). Care should be taken when applying Lamisil spray on damaged skin, as ethanol, which is part of it, can cause irritation. Lamisil Spray is for external use only. Do not use Lamisil spray on the skin of the face. If Lamisil spray was accidentally introduced into the respiratory tract during inhalation, then in the event of any symptoms, and especially when they persist, you should consult with your doctor. Lamisil Spray contains propylene glycol, which in some cases may cause skin irritation. It should also be borne in mind that the drug contains ethanol 96%.