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Active ingredients
Bifidobacteria + Lactobacillus
Release form
Capsules
Composition
Powder Probiotech AB Blend 64 (Probio-tec; AB Blend 64) 60 mg, including Lactobacillus acidophilus (LA-5) 13.8 mg; Bifidobacterium animalis subsp. lactis (BB-12) 4.2 mg; Supplementary ingredients of the active ingredient: anhydrous dextrose - 29.1 mg, microcrystalline cellulose - 6 mg, potato starch - 6 mg, magnesium stearate - 0.9 mg. Auxiliary substances: Beneo Synergi 1 (Beneo; Synergy 1 - 171.5 mg (powder contains 90-94% inulin and 6-10% oligofructose (dextrose + fructose + sucrose)), magnesium stearate - 3.5 mg. Capsule body composition: hypromellose - 33.149 mg, titanium dioxide (E171) - 0.691 mg.; The composition of the capsule cap: hypromellose - 22.08 mg, titanium dioxide (E171) - 0.24 mg, iron dye yellow oxide (E172) - 0.24 mg.
Pharmacological effect
The drug that regulates the balance of intestinal microflora. One capsule of the drug Linex; Forte contains 2 × 109 colony forming units of live lyophilized lactic acid bacteria: Lactobacillus acidophilus (LA-5) and Bifidobacterium animalis subsp. lactis (BB-12). Live lactic acid bacteria are a normal component of the natural intestinal microflora.; Lactic acid bacteria perform a protective function by synthesizing substances with antibacterial activity, produce enzymes, under the influence of which hydrolysis of cellulose, proteins, fats, starch and deconjugation of bile acids occurs, and also participate in the synthesis of vitamins of the group B, C, K, amino acids, organic acids; Lactic acid bacteria LA-5 and BB-12 inhibit the growth of pathogenic bacteria by: - shifting the pH of the intestine to the acidic side ( Performan ability LA-5 synthesized lactic acid and 12 to synthesize the BB-acetic and succinic acids in addition to lactic acid); - production of metabolites that have a toxic effect on pathogenic bacteria (formation of H2O2); - formation of antimicrobial substances, bacteriocins (LA-5 secretes acidocyan, a broad-spectrum bacteriocin, which prevents the growth of bacteria and fungi); - competition with pathogenic bacteria for nutrients; - interacting with adhesion receptors, thus preventing the colonization of other potentially pathogenic microorganisms.
Pharmacokinetics
Lactic acid bacteria, such as LA-5 and BB-12, act directly in the gastrointestinal tract; when taken orally, the drug is not subjected to systemic absorption. Standard pharmacokinetic studies are therefore not applicable.The resistance of LA-5 and BB-12 to the effects of gastric juice and bile allows the strains to maintain their viability in large quantities when passing through the stomach and duodenum. Both strains are attached to the intestinal mucosa. Like other microorganisms, gradually excreted from the gastrointestinal tract with feces.
Indications
- treatment and prevention of intestinal dysbiosis;
Contraindications
- hereditary intolerance to fructose, sucrase-isomaltase deficiency or glucose / galactose malabsorption syndrome; - Hypersensitivity to the components of the drug. With caution should use the drug for diabetes mellitus (it consists of simple sugars), a lack of immune system (for example, HIV infection).
Use during pregnancy and lactation
Due to the lack of data on the use of the drug in pregnant women is not recommended to take Linex; Forte during pregnancy and lactation (breastfeeding) without prior consultation with the doctor. In the appointment of the drug for the treatment of acute diarrhea during pregnancy and lactation, it is necessary to monitor the doctor.
Dosage and administration
The drug is taken orally, preferably during or after a meal. Capsules should be taken with a small amount of liquid. When prescribing the drug Linex; Forte children and patients who cannot swallow the capsule completely should be opened, poured the contents into a spoon and mixed with a small amount of liquid. For adults and adolescents over 12 years old, prescribe 1 caps. 1-3 times / day; Children aged 2 to 12 years - 1 caps. 1-2 times / day; Newborns and children under the age of 2 years - 1 caps. 1 time / day; diarrhea in children under 6 years old must be treated under medical supervision.; The duration of treatment depends on the cause of the development of dysbiosis and the individual characteristics of the organism. Drug Linex; Forte can be taken until the symptoms of dysbacteriosis disappear. You should not exceed the recommended dose of the drug.
Side effects
The drug is well tolerated. No adverse effects have been reported, but hypersensitivity reactions may occur.
Overdose
Data on the symptoms of an overdose of the drug Linex; Forte no.
Interaction with other drugs
No undesirable interaction of the drug Linex was observed; Forte with other drugs. With the simultaneous use of antibiotics, the recommended interval between taking the drug (antibiotic) and Linex capsules; Forte should be 3 hours.
special instructions
Do not drink Linex; Forte hot drinks and take along with alcohol.; The patient should consult a doctor if before starting to use the drug his body temperature is above 38 ° C, blood or mucus in the stool, diarrhea lasts more than 2 days and is accompanied by acute abdominal pain, dehydration and weight loss; as well as in the presence of chronic diseases (diabetes mellitus, HIV infection) .; When treating diarrhea, it is necessary to replace lost fluid and electrolytes. There is no need for special precautions when eliminating the unused drug Linex; Forte.; Use in pediatrics; Diarrhea in children under the age of 6 years should be treated under the supervision of a physician.; Effect on ability to drive motor vehicles and control mechanisms; The drug does not affect the ability to drive motor vehicles and control mechanisms.