Melaritm pills coated 3mg N24
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Description
Melaritm pills are a synthetic analogue of the hormone of the pineal gland (epiphysis). Normalize circadian rhythms. Regulate the sleep-wake cycle, daily changes in locomotor activity and body temperature. They contribute to the normalization of night sleep (accelerate falling asleep, improve the quality of sleep, reduce the number of nightly awakenings, improve well-being after the morning awakening, do not cause a feeling of lethargy, weakness and fatigue upon waking, dreams become more vivid and emotionally saturated). Adapt the body to the rapid change of time zones, reduce stress reactions.
Active ingredients
Melatonin
Release form
Pills
Composition
The active substance is melatonin 3 mg. Auxiliary substances: microcrystalline cellulose - 82.4 mg, croscarmellose sodium (sodium starch glycolate) - 10.5 mg, calcium phosphate dihydrate - 82.4 mg, mannitol - 44 mg, macrogol 6000 (polyethylene glycol 6000) - 15 mg, magnesium stearate - 2.7 mg. The composition of the shell: opadry II (polyvinyl alcohol - 2.4 mg, titanium dioxide - 1.5 mg, macrogol - 1.212 mg, talc - 0.888 mg).
Indications
Sleep disorders, incl. caused by the disturbance of the rhythm "sleep-wakefulness", such as desynchronosis (abrupt change of time zones).
Precautionary measures
During the period of use of the drug is recommended to avoid exposure to bright light. It is necessary to inform women who want to become pregnant about the presence of a weak contraceptive effect.
Dosage and administration
Drain down with enough water. At 3–6 mg / day for an hour before sleep for 4–7 days. With desynchronosis (sudden change of time zones) 6 mg 1 hour before sleep. followed by 3 mg in the first three days. Renal failure The effect of varying degrees of renal failure on melatonin pharmacokinetics has not been studied, so melatonin should be used with caution in such patients. The use of the drug is not recommended for patients with severe renal insufficiency. Hepatic insufficiency There is no experience with the use of melatonin in patients with impaired liver function. Published data show a marked increase in the concentration of endogenous melatonin during daytime hours as a result of reduced clearance in these patients.Therefore, melatonin is not recommended for patients with impaired liver function. Older patients It is well known that melatonin metabolism slows down with age, however, due to the high inter-individual variability of pharmacokinetic parameters, even within groups with the same gender, it is difficult to advise on the dose adjustment for elderly patients.
Side effects
Infectious and parasitic diseases: rarely - herpes zoster. From the blood and lymphatic system: rarely - leukopenia, thrombocytopenia. From the immune system: frequency unknown - hypersensitivity reactions. From the side of metabolism and nutrition: rarely - hypertriglyceridemia, hypokalemia. Psychiatric disorders: infrequently - irritability, neurosis, anxiety, insomnia, unusual dreams, nightmares, anxiety, rarely - mood swings, aggression, agitation, tearfulness, symptoms of stress, disorientation, early morning awakening, increased libido, decreased mood, depression On the nervous system: infrequently - migraine, headache, lethargy, psychomotor hyperactivity, dizziness, drowsiness, rarely - fainting, impaired memory, impaired concentration, dreaming state, si Ndrom "restless" legs, poor quality of sleep. paresthesia. On the part of the organ of vision: rarely - reduced visual acuity, blurred vision, increased tearing. On the side of the organ of hearing and labyrinth disturbances: rarely - vertigo, positional vertigo. On the side of the heart: rarely - angina pectoris, heartbeat. On the side of the vessels: infrequently - arterial hypertension, rarely - "tides". On the side of the gastrointestinal tract: infrequently - abdominal pain, abdominal pain in the upper abdomen, dyspepsia, ulcerative stomatitis, dry mouth, nausea, rarely - gastroesophageal reflux disease, gastrointestinal ishechnoe disturbance or disorder, the formation of bubbles on the oral mucosa. ulcerative glossitis, vomiting, abnormal intestinal noise, abdominal distension, hypersecretion of saliva, bad breath, abdominal diskofort, indigestion, gastritis. On the part of the liver and biliary tract: rarely - hyperbilirubinemia. night sweats, itching and generalized itching.rash, dry skin, rarely - eczema, erythema, hand dermatitis, psoriasis, generalized rash, itchy rash, nail damage, frequency unknown - Quincke edema, swelling of the mouth, swelling of the tongue. Musculoskeletal and connective tissue: infrequently - pain limbs, rarely - arthritis, muscle spasm, neck pain. night cramps. From the kidneys and urinary tract: infrequently - glucosuria, proteinuria, rarely - polyuria, hematuria, nocturia. From the genitals and mammary gland: infrequent - menopausal symptoms, rarely - priapism, prostatitis, frequency unknown - galactorrhea. General disorders and irregularities at the injection site: infrequently - asthenia, chest pain, rarely - fatigue, pain, thirst. Laboratory and instrumental data: rarely - abnormal laboratory parameters of liver function, weight gain, rarely - increased activity " echenochnyh "enzymes, abnormal content of electrolytes in the blood, abnormal laboratory results testov.Esli any of these adverse reactions in instructions are compounded or you notice other side effects not mentioned in the instructions, tell your doctor.
Overdose
Symptoms Increased severity of side effects. Treatment. Gastric lavage, symptomatic therapy.
special instructions
Contraindications to the use of hypersensitivity to the drug, - autoimmune diseases, - liver failure, - severe renal failure, - children under 18 years of age.