Mezim Forte 10000 pills of 20 pieces
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Active ingredients
Pancreatin
Release form
Pills
Composition
; Pancreatin 137.5 mg, with a minimum of enzymatic activity: 10,000 IU of lipase Ph.Eur, amylase 7500 units Ph.Eur, proteases 375 U Ph.Eur.Vspomogatelnye substances: lactose monohydrate, microcrystalline cellulose, colloidal silicon dioxide, crospovidone, magnesium stearate. ; Shell composition: hypromellose, copolymer of methacrylic acid and ethyl acrylate (1: 1) dispersion 30% (dry weight), triethyl citrate, titanium dioxide (E171), talc, simethicone emulsion 30% (dry weight), macrogol 6000, carmellose sodium, polysorbate 80 , azorubic varnish (E122), sodium hydroxide.
Pharmacological effect
; Enzymatic drug that improves digestion. Pancreatin is a powder of porcine pancreas glands, in which, along with exocrine pancreatic enzymes — lipase, amylase, protease, trypsin, and chymotrypsin — contain other enzymes. The pancreatic enzymes that make up the drug facilitate the breakdown of proteins, fats and carbohydrates, which leads to their more complete absorption in the small intestine. Trypsin inhibits stimulated secretion of the pancreas, providing an analgesic effect. The maximum enzymatic activity of the drug is noted in 30-45 minutes after oral administration.
Pharmacokinetics
; Mezim forte 10000 pills are coated with an acid-resistant coating that does not dissolve under the action of the hydrochloric acid of the stomach and thus protects the enzymes contained in the preparation from inactivation. The dissolution of the shell and the release of enzymes occurs at a pH close to neutral or slightly alkaline.
Indications
- replacement therapy for exocrine pancreatic insufficiency (including chronic pancreatitis, cystic fibrosis) - chronic inflammatory and dystrophic diseases of the stomach, intestines, liver, gall bladder — states after resection or irradiation of the gastrointestinal organs, accompanied by a violation of food digestion, meteorism, diarrhea (as part of combination therapy) - a functional disorder of the gastrointestinal tract (with intestinal infectious diseases, irritable bowel syndrome, etc.) - to improve food digestion in patients with normal gastrointestinal function in the event of errors in pitanii- preparation for X-ray and ultrasound examination of the abdominal cavity.
Contraindications
- acute pancreatitis; - exacerbation of chronic pancreatitis; - hypersensitivity to Pancreatin or other components of the drug; - hereditary intolerance to galactose, lack of lactase or glucose-galactose malabsorption syndrome; - children's age up to 3 years (indivisible dosage form).
Use during pregnancy and lactation
Due to the lack of sufficient data on the use of pancreatic enzymes in humans during pregnancy and lactation, the use of Mezim Forte 10,000 is possible only if the expected benefit to the mother outweighs the possible risk to the fetus or child.
Dosage and administration
; The dose of the drug Mezim Forte 10000 is set individually depending on the severity of the disease and the composition of the food. If there are no other indications, the average single dose for adults is 2-4 tab. Mezim forte 10000 for food intake. It is recommended to take half or a third of a single dose at the beginning of a meal, and the rest during it. The drug is taken orally, without chewing and drinking plenty of fluids. You may increase the dose, which should be carried out only under the supervision of a physician, focusing on the weakening of symptoms (for example, steatorrhea, abdominal pain). The maximum daily dose - 15000-20000 IU Ph.Eur. lipase / kg body weight. The dosage regimen is determined by the doctor depending on the severity of the disease and the composition of the food at the rate of 500-1000 IU Ph.Eur. lipase / kg body weight of the child for each meal. The duration of treatment can vary from several days (in case of digestive disorders, errors in diet) to several months and even years (if necessary, constant replacement therapy).
Side effects
No development of side effects or complications has been identified even with prolonged and regular use of Mezim Forte 10,000 in patients with impaired pancreatic function. In some cases, after taking pancreatin, allergic reactions may develop; rarely - diarrhea or constipation, nausea, epigastric discomfort. In isolated cases in patients suffering from cystic fibrosis, with prolonged use of high doses of the drug may develop hyperuricosuria (increased uric acid levels in the blood plasma), the formation of strictures in the ileocecal region and the ascending colon.
Overdose
; There is no data on cases of overdose and drug intoxication. Possible: hyperuricosuria. hyperuricemia, in children - constipation.Treatment: drug withdrawal, symptomatic therapy.
Interaction with other drugs
; When taking drugs containing pancreatin, it is possible to reduce the absorption of folic acid. The effect of glucose-lowering drugs (acarbose, miglitol) may decrease while taking it with pancreatin. With simultaneous use of pancreatin with iron preparations may decrease the absorption of the latter. The simultaneous use of antacids containing calcium carbonate and / or magnesium hydroxide, can lead to a decrease in the effectiveness of the drug.
special instructions
; In acute pancreatitis or exacerbation of chronic pancreatitis (at the stage of attenuation of exacerbation), during a restorative diet, it is advisable to appoint Mezim Forte 10000 against the background of the pancreas function that remains or remains in the future. Mezim Forte 10000, taking into account the solid indivisible dosage form, is contraindicated in children under 3 years. The influence of the drug on the ability to drive vehicles and control mechanisms: Mezim Forte 10000 does not affect the speed of psychomotor reactions and the ability to perceive or assess the situation.