Naklofen CP pills long.pl about 100mg N20
Condition: New product
1000 Items
Rating:
Be the first to write a review!
More info
Active ingredients
Diclofenac
Release form
Pills
Composition
1 tab. Diclofenac Sodium 100 mg. Excipients: L-methionine - 0.447 mg, sodium sulfate anhydrous - 1.704 mg, sodium dihydrogen phosphate monohydrate - 0.414 mg, mannitol - 9 mg, poloxamer 188 - 0.03 mg, dilute hydrochloric acid or sodium hydroxide solution (qs to pH 6.2), water di.
Pharmacological effect
Diclofenac is a non-steroidal anti-inflammatory drug that has an analgesic, anti-inflammatory and antipyretic effect. The main mechanism of its action and the associated side effects are the indiscriminate inhibition of the activity of the cyclooxygenase 1 and 2 enzyme (COX1 and COX2), which leads to disruption of arachidonic acid metabolism, reduced synthesis of prostaglandins, prostacyclin and thromboxane. Synthesis of prostaglandins in the kidneys, gastric mucosa and synovial fluid is reduced. Most effective for inflammatory pain. In rheumatic diseases, the anti-inflammatory and analgesic action of diclofenac significantly reduces the severity of pain, morning stiffness, swelling of the joints, which improves the functional state of the joint. With injuries in the postoperative period, diclofenac reduces pain and inflammatory edema. Like all nonsteroidal anti-inflammatory drugs (NSAIDs), diclofenac has antiplatelet activity. At therapeutic doses, diclofenac has virtually no effect on bleeding time. With long-term treatment, the analgesic effect of diclofenac is not reduced.
Indications
- inflammatory and degenerative diseases of the musculoskeletal system: rheumatoid arthritis, psoriatic, juvenile chronic arthritis, ankylosing spondylitis (ankylosing spondylitis), gouty arthritis (in an acute attack it is preferable to use fast-acting dosage forms), arthritis in Reiter’s disease, rheumatism, rheumatism, rheumatoid arthritis, rheumatoid arthritis (rheumatoid arthritis); peripheral joints and the spine, including those with radicular syndrome, tendovaginitis, periarthritis, bursitis, myositis, synovitis). - pain syndrome of weak or moderate severity: neuralgia, myalgia, lumboischialgia, post-traumatic pain syndrome, accompanied by inflammation,postoperative pain, headache, migraine (in an acute attack it is preferable to use fast-acting dosage forms), algomenorrhea, adnexitis, proctitis, toothache, renal and biliary colic. - as part of a complex treatment of infectious and inflammatory diseases of the ear, throat, nose with severe pain (pharyngitis, tonsillitis, otitis media). - febrile syndrome. Diclofenac is intended for symptomatic therapy and is not affected by disease progression.
Contraindications
- the period after coronary artery bypass grafting - erosive-ulcerative changes in the mucous membrane of the stomach or duodenum 12, active gastrointestinal bleeding .. - inflammatory bowel disease, in the acute phase (Ulcerative colitis (NUC), Crohn's disease). - cerebrovascular bleeding or other bleeding and disorders of hemostasis - severe liver failure or active liver disease - severe renal failure (creatinine clearance less than 30 ml / min), including confirmed hyperkalemia, progressive kidney disease - decompensated heart failure - bone marrow suppression - bone marrow hemorrhage trimester of pregnancy, breastfeeding period - children's age (up to 18 years) - hypersensitivity to diclofen-full or incomplete th combination of asthma, recurrent nasal polyposis and paranasal sinuses and intolerance to acetylsalicylic acid and other NSAIDs (including history). Precautions: ischemic heart disease, cerebrovascular diseases, dyslipidemia / hyperlipidemia, diabetes mellitus, peripheral artery disease, smoking, creatinine clearance less than 60 ml / minamnesternistnye data on the development of ulcerative lesions of the gastrointestinal tract, the presence of Helicobacter pylori infection, elderly age, long nonsteroidal anti-inflammatory drugs (NSAIDs), frequent use of alcohol, severe somatic diseases, induced porphyria, epilepsy, old age, diverticula t, systemic connective tissue diseases, a significant decrease in circulating blood volume (BCC) (including after massive surgery), elderly patients (prescribed in lower doses) (including receiving diuretics,weakened patients and low body weight), concomitant therapy with the following drugs: anticoagulants (for example, warfarin), antiplatelet agents (for example, acetylsalicylic acid, clopidogrel), fibrinolytics, oral glucocorticoids (for example, prednisolone), selective serotonin reuptake inhibitors (for example, citrol corticosteroids (for example, prednisolone), selective serotonin reuptake inhibitors (for example, citrol corticosteroids) , fluoxetine, paroxetine, sertraline). To reduce the risk of adverse gastrointestinal development, a minimum effective dose should be used with the minimum possible course. Pregnancy I-II trimester.
Use during pregnancy and lactation
The use of diclofenac in pregnant women is possible only when the expected benefit outweighs the potential risk to the fetus. Diclofenac is not recommended for use during the last trimester of pregnancy. Despite the fact that diclofenac is found in breast milk in small quantities, its use during breastfeeding is not recommended.
Dosage and administration
Inside, the pills should be swallowed whole, not chewed, squeezed with a sufficient amount of water during or after a meal. Naklofen CP, long-acting pills, 100 mg should be used for long-term therapy. The initial and maintenance doses are 1 tablet per day. If necessary, increase the dose to 150 mg per day. Naklofen CP should be combined with 50 mg Naklofen pills or suppositories.
Side effects
Often - 1-10%. sometimes 0.1-1%. rarely 0.01–0.1%. very rarely - less than 0.01%, including some cases. On the part of the digestive system: often - epigastric pain, abdominal cramps, nausea, vomiting, diarrhea, dyspepsia, flatulence, anorexia, increased activity of aminotransferases. rarely - gastritis, proctitis, bleeding from the gastrointestinal tract (GIT) (vomiting with blood, melena, diarrhea with blood), gastrointestinal ulcers (with or without bleeding or perforation), hepatitis, jaundice, abnormal liver function. very rarely - stomatitis, glossitis, dry mucous membranes (including the mouth), esophageal damage, diaphragm-like intestinal strictures (nonspecific hemorrhagic colitis, exacerbation of ulcerative colitis or Crohn's disease), constipation, pancreatitis, fulminant hepatitis.On the part of the nervous system: often - headache, dizziness. rarely - drowsiness. very rarely - a violation of sensitivity, incl. paresthesias, memory disorders, tremor, convulsions, anxiety, cerebrovascular disorders, aseptic meningitis, disorientation, depression, insomnia, nightmares, irritability, agitation, mental disorders. From the senses: often - vertigo. very seldom - visual impairment (blurred vision, diplopia), hearing loss, tinnitus, taste impairment. On the part of the urinary system: very rarely - acute renal failure, hematuria, proteinuria, interstitial nephritis, nephrotic syndrome, papillary necrosis, edema. On the part of the blood-forming organs: very rarely - thrombocytopenia, leukopenia, eosinophilia, hemolytic and aplastic anemia, agranulocytosis. Allergic reactions: anaphylactic, anaphylaccoid reactions, including marked reduction in blood pressure (BP) and shock. very rarely - angioedema (including faces), in some cases, vasculitis. Since the cardiovascular system: very rarely - palpitations, tachycardia, extrasystole, chest pain, increased blood pressure, vasculitis, heart failure, myocardial infarction. On the part of the respiratory system: rarely - cough, bronchial asthma (including shortness of breath). very rarely - pneumonitis, laryngeal edema. For the skin: often - skin rash. rarely - urticaria. very rarely - bullous eruptions, eczema, incl. multiforme and Stevens-Johnson syndrome, Lyell's syndrome, exfoliative dermatitis, pruritus, hair loss, photosensitization, purpura, incl. allergic.
special instructions
Often - 1-10%. sometimes 0.1-1%. rarely 0.01–0.1%. very rarely - less than 0.01%, including some cases. On the part of the digestive system: often - epigastric pain, abdominal cramps, nausea, vomiting, diarrhea, dyspepsia, flatulence, anorexia, increased activity of aminotransferases. rarely - gastritis, proctitis, bleeding from the gastrointestinal tract (GIT) (vomiting with blood, melena, diarrhea with blood), gastrointestinal ulcers (with or without bleeding or perforation), hepatitis, jaundice, abnormal liver function. very rarely - stomatitis, glossitis, dry mucous membranes (including the mouth), esophageal damage, diaphragm-like intestinal strictures (nonspecific hemorrhagic colitis, exacerbation of ulcerative colitis or Crohn's disease), constipation, pancreatitis, fulminant hepatitis.On the part of the nervous system: often - headache, dizziness. rarely - drowsiness. very rarely - a violation of sensitivity, incl. paresthesias, memory disorders, tremor, convulsions, anxiety, cerebrovascular disorders, aseptic meningitis, disorientation, depression, insomnia, nightmares, irritability, agitation, mental disorders. From the senses: often - vertigo. very seldom - visual impairment (blurred vision, diplopia), hearing loss, tinnitus, taste impairment. On the part of the urinary system: very rarely - acute renal failure, hematuria, proteinuria, interstitial nephritis, nephrotic syndrome, papillary necrosis, edema. On the part of the blood-forming organs: very rarely - thrombocytopenia, leukopenia, eosinophilia, hemolytic and aplastic anemia, agranulocytosis. Allergic reactions: anaphylactic, anaphylaccoid reactions, including marked reduction in blood pressure (BP) and shock. very rarely - angioedema (including faces), in some cases, vasculitis. Since the cardiovascular system: very rarely - palpitations, tachycardia, extrasystole, chest pain, increased blood pressure, vasculitis, heart failure, myocardial infarction. On the part of the respiratory system: rarely - cough, bronchial asthma (including shortness of breath). very rarely - pneumonitis, laryngeal edema. For the skin: often - skin rash. rarely - urticaria. very rarely - bullous eruptions, eczema, incl. multiforme and Stevens-Johnson syndrome, Lyell's syndrome, exfoliative dermatitis, pruritus, hair loss, photosensitization, purpura, incl. allergic.