Buy Nimesulide Teva tablets 100mg N30

Nimesulide Teva pills 100mg N30

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Active ingredients

Nimesulide

Release form

Pills

Composition

1 tablet contains: Active ingredient: nimesulide 100 mg. Excipients: 1.5 mg of sodium dusate, 0.8 mg of hyprolosis, 153.7 mg of lactose monohydrate, sodium carboxymethyl starch of 35 mg, 100 mg of microcrystalline cellulose, 1 mg of magnesium stearate, 8 mg of vegetable oil.

Pharmacological effect

NSAIDs, in the structure of which there is a sulfonylide group. Nimesulide is believed to be a selective COX-2 inhibitor. It has a pronounced anti-inflammatory, as well as analgesic and to a lesser extent antipyretic effect. The mechanism of action is associated with inhibition of prostaglandin synthesis. Suppresses the synthesis of prostaglandins in the area of ​​inflammation to a greater extent than in the gastric mucosa or kidneys, which is mainly due to inhibition of COX-2. Furthermore, in the mechanism of nimesulide's anti-inflammatory action, its ability to suppress the formation of free oxygen radicals (without affecting hemostasis and phagocytosis ) and inhibit the release of the enzyme myeloperoxidase.

Pharmacokinetics

After ingestion, nimesulide is well absorbed from the gastrointestinal tract, Cmax in the blood plasma is achieved in 1-2 hours; Protein binding is 99%. After ingestion of a single dose of 100 mg, nimesulide is present in the tissues of the female genital organs at a concentration of 40% of the concentration in plasma.; Metabolized in the liver, the main metabolite hydroxyneminosulide has pharmacological activity.; T1 / 2 from plasma is 2-3 hours; Excreted mainly from the body with urine, about 98% of the dose is eliminated within 24 hours. With prolonged therapy, nimesulide does not accumulate.

Indications

Rheumatoid and psoriatic arthritis; gout in the acute stage, articular syndrome; osteochondrosis and osteoarthritis; inflammation of the ligaments and muscle pain; neuralgia and myalgia; post-traumatic and postoperative pain; pain syndrome (toothache, headache, recurrent pain in women); fever subfebrile and febrile values ​​in infectious and inflammatory diseases. The drug "Nimesulide-Teva" instructions for use can be used in complex therapy for otitis, sinusitis, meningitis, bronchitis, pneumonia and other diseases.

Contraindications

It is forbidden to take the drug in case of hypersensitivity to nimesulide, as well as possible allergies to aspirin or other nonsteroidal drugs with anti-inflammatory effect.If there are lesions of the gastrointestinal tract ulcers or intestinal bleeding. Available liver or kidney failure. Heart failure or blood disorders. In the presence of these circumstances in the history is necessary to consult a specialist. The use of the drug in children, for expectant mothers and during lactation is unacceptable.

Use during pregnancy and lactation

Nimesulide is contraindicated for use during pregnancy and lactation. There is no direct indication of the embryotoxic and tocolytic effect of nimesulide.

Dosage and administration

The drug is recommended to be taken after meals. Tablets do not require pre-grinding and are swallowed whole with a sufficient amount of water. Do not drink the drug with hot drinks, milk and juices. The drug "Nimesulide-Teva" dosage is 100 milligrams for a single dose. Per day is allowed to use the drug twice. The duration of therapy depends on the course of the disease. As an antipyretic medication, pills are consumed for no more than three days. When pain therapy is allowed for five days of treatment. If the agent is prescribed for inflammatory processes, then an individual approach to each patient is chosen.

Side effects

Before you use Nimesulide-Teva, you should familiarize yourself with the available reviews about the drug. The drug, like many of its analogues, has side effects. These include allergies in the form of a rash, hives or edema. There are chances of developing digestive problems: diarrhea, constipation, abdominal pain, intestinal bleeding. Tablets can cause high blood pressure, tachycardia. There is a possibility of bronchospasm. In this case, patients who are prone to similar effects should be in possession of appropriate medication. Some consumers say the drug has lowered body temperature too much. The result of this action was hypothermia. In a group of individuals, the remedy causes dizziness, headache, and even panic attacks. There are negative reviews about pills, but they are quite few. Most of the product is well tolerated by consumers and has a positive effect.

Interaction with other drugs

Manifestations of drug interactions are possible with simultaneous ingestion of nimesulide with digoxin, phenytoin, lithium preparations, diuretics, antihypertensive drugs, other NSAIDs, anticoagulants, cyclosporine, methotrexate, oral hypoglycemic agents.

special instructions

With caution, the drug is used in patients prone to bleeding. Do not use the medicine immediately after surgery, as there is a high probability of bleeding. You also need to be careful while using anticoagulants and venotonics. Due to the fact that nimesulide is excreted by the kidneys, the drug should be carefully taken with pyelonephritis and nephritis. If at the same time the patient consumes diuretics, the effect of the action of the drug can be reduced. The drug "Nimesulide-Teva" can cause fluid retention in the body. It is worth paying attention to people suffering from edema and high blood pressure.

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