Oftan Katahrom eye drops 10 ml
Condition: New product
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Active ingredients
Adenosine + Nicotinamide + Cytochrome C
Release form
Drops
Composition
On 1 ml: cytochrome C 675 mkg, adenosine 2 mg, nicotinamide 20 mg. Excipients: benzalkonium chloride, sodium succinate hexahydrate, sorbitol, sodium dihydrogen phosphate dihydrate, sodium hydrogen phosphate dihydrate, water d / and.
Pharmacological effect
Combined medication that improves the energy metabolism of the lens. Cytochrome C plays an important role in biochemical redox processes in the tissues of the eyeball and is an antioxidant. Adenosine is a precursor of ATP, is involved in the metabolic processes of the lens.
Pharmacokinetics
Absorption and distribution When applied topically, cytochrome C is not absorbed into the systemic circulation. Adenosine penetrates the cornea well. Metabolism and elimination Cytochrome C is completely metabolized in the body in the same way as amino acids, and heme is split into bilirubin, which is excreted in the bile. all tissues with the formation of inosine, xanthine and urate, which are excreted in the urine. Ribose, which is part of the adenosine molecule, is metabolized to glyceraldehyde-3-phosphate, and then to pyruvate, and finally split into the Krebs cycle. T1 / 2 adenosine from plasma is less than 1 min. Nicotinamide is partially metabolized to nicotinic acid. Both compounds are methylated to form N-methylnicotinamide, which is further cleaved in the liver. Unchanged nicotinamide and metabolites are excreted in the urine.
Indications
Cataract of various origins.
Contraindications
- children and adolescents up to 18 years (due to the lack of data on the efficacy and safety of the use of the drug in children and adolescents) - hypersensitivity to the components of the drug.
Use during pregnancy and lactation
There is not enough experience with the drug Oftan Katahrom during pregnancy and lactation (breastfeeding). It is possible to use Oftan Katahrom during pregnancy and lactation as prescribed by a doctor and when the expected benefit of therapy for the mother outweighs the potential risk to the fetus or infant .
Dosage and administration
Assign 1-2 drops to the conjunctival sac 3 times / day. When using the bottle for the first time, turn the bottle cap with a simultaneous pressing down and then open the bottle
Side effects
On the part of the organ of vision: short-term burning sensation and tingling of the eyes, allergic conjunctivitis, contact dermatitis. Systemic reactions: extremely rare - short-term nausea, hypotension, dizziness, shortness of breath; sensation of heat and pulsation in the temples, fainting (due to the vasodilating action of nicotinic acid).
Overdose
Data on overdose of the drug Oftan Katahrom not available.
Interaction with other drugs
No clinically significant interaction of Oftan Katahrom with other drugs was found.
special instructions
During the period of treatment with Oftan Katahrom, do not wear soft contact lenses, since the preservative may be deposited in them and adversely affect the tissue of the eye. Before using Oftan Katahroma, contact lenses should be removed and installed again 15 minutes after the instillation of the drug. Effect on ability to drive vehicles and control mechanisms Patients who have short-term eye irritation after instillation of the drug should avoid driving vehicles, working with equipment, machines or any other equipment that requires good visual acuity immediately after the use of eye drops.