Picamilon injection solution ampoules 10% 2ml N10
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Active ingredients
Nicotinoyl gamma-aminobutyric acid
Release form
Solution
Composition
1 ml (1 amp) of the solution contains: Active ingredient: N-nicotinoyl-gamma-aminobutyric acid sodium salt 100 mg (200 mg).
Pharmacological effect
Nootropic agent, dilates the blood vessels of the brain. It also has a tranquilizing, psychostimulant, antiplatelet and antioxidant effects. Improves the functional state of the brain due to the normalization of tissue metabolism and effects on cerebral circulation (increases the volumetric and linear speed of cerebral blood flow, reduces the resistance of cerebral vessels, suppresses platelet aggregation, improves microcirculation). In exchange admission increases physical and mental performance, reduces headache, improves memory, normalizes sleep; helps to reduce or eliminate feelings of anxiety, tension, fear; improves the condition of patients with motor and speech disorders.
Pharmacokinetics
Absorption is fast and complete, regardless of the route of administration. It penetrates the BBB and is retained for a long time in the tissues of the body. Bioavailability - 50-88%. Excreted mainly by the kidneys in unchanged form. T1 / 2 - 0.51 hour
Indications
Cerebrovascular insufficiency, vegetative-vascular dystonia, asthenic syndrome, depressive disorders in the elderly. Conditions accompanied by anxiety, fear, increased irritability, emotional lability. Asthenic conditions caused by various neuropsychiatric diseases. As part of a comprehensive treatment for the relief of acute alcohol intoxication. In chronic alcoholism to reduce asthenic, asthenoneurotic, postpsychotic, pre-relapse states, as well as alcoholic encephalopathy. As part of complex therapy, migraine, cranial trauma, neuroinfection. Improving the tolerance of physical and mental stress (for people in tense and extreme conditions of activity. To restore physical performance of athletes, to increase resistance to physical and mental stress). Open-angle glaucoma (to stabilize the visual function).In urological practice (in children older than 3 years and in adults with urinary disorders) to improve the adaptive function of the bladder (reduction of detrusor hypoxia).
Contraindications
Hypersensitivity, CRF.
Precautionary measures
From the side of the central nervous system: irritability, agitation, anxiety, dizziness, headache.
Use during pregnancy and lactation
Contraindicated use during pregnancy, during lactation (breastfeeding).
Dosage and administration
In / in drip or jet (slowly), in / m. Before the drip, the contents of the ampoule are dissolved in 200 ml of 0.9% sodium chloride solution. With chronic cerebral circulatory disorders - in / in or in / m, 0.1-0.2 g, 1-2 times a day, in a daily dose of 0.2-0.4 g. Depending on the condition of the patient, prescribed in the morning in / in the drip, in the evening in / m; or 10 days in / in, then in / m. The course of treatment is 15-30 days. In asthenic conditions, depending on the severity of the disease, except for oral administration - in / m, in a daily dose of 0.2-0.4 g (2-4 ml of 10% solution), for 1 month. For the treatment of alcoholism - 0.6-0.8 g / day. The course of treatment is 1 month. To relieve acute uncomplicated intoxication with ethanol as part of complex therapy, a 5 mg / kg saturating dose and 1.56 mg / kg / h maintenance dose are administered in a volume of 2.5 liters of infusion solution, for 4 hours, in the morning and evening.
Side effects
Increased irritability, agitation, anxiety, dizziness, headache, nausea, allergic reactions (skin rash, itching).
Interaction with other drugs
Reduces the duration of the action of barbiturates. Enhances the effect of narcotic analgesics.