Potassium Iodide-OBL Tablets 200mcg N100
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Active ingredients
Potassium iodide
Release form
Pills
Composition
1 tablet contains: Active ingredient: potassium iodide 262 mcg, incl. iodine 200 mcg.
Pharmacological effect
Means containing inorganic iodine. When iodides enter the epithelium of the follicle of the thyroid gland under the influence of the enzyme iodide peroxidase, iodine is oxidized to form elemental iodine, which is incorporated into the tyrosine molecule. In this case, one part of the tyrosine radicals in thyroglobulin is iodized. Iodinated tyrosine radicals are condensed into thyronines, the main of which are thyroxin (T4) and triiodothyronine (T3). The resulting complex of thyronin and thyroglobulin is released as a deposited form of thyroid hormone into the follicle colloid and remains in this state for several days or weeks. With iodine deficiency, this process is disturbed. Potassium iodide, compensating for iodine deficiency, helps to restore impaired synthesis of thyroid hormones. At normal iodine levels in the environment, under the influence of an excess of iodides, the biosynthesis of thyroid hormones is inhibited, their release from thyreoglobulin decreases, the thyroid gland's sensitivity to thyroid-stimulating hormone of the pituitary gland is reduced, and the secretions of the pituitary gland and the secretion of the secretion of the thyroid gland are blocked
Pharmacokinetics
When ingestion is rapidly absorbed from the digestive tract. Widely distributed in all tissues and body fluids.
Indications
Prevention and treatment of endemic goiter. Prevention of relapse of goiter in the period of the complex treatment of thyroid hormone drugs.
Contraindications
Severe hyperthyroidism, latent hyperthyroidism (when used in doses exceeding 150 mcg / day), toxic adenoma, nodular or diffuse toxic goiter (when used in doses of 300-1000 mcg / day), herpetiform dermatitis (Duhring's disease), pregnancy and breastfeeding (when used in doses of 1-2 mg / day), hypersensitivity to iodine preparations.
Use during pregnancy and lactation
In pregnancy, use is possible only in recommended doses, since iodine penetrates the placental barrier and can cause the development of hypothyroidism and goiter in the fetus. Iodine is excreted in breast milk. When applied to the mother during lactation (breastfeeding) in doses of more than 1 mg / day, there is a risk of developing hypothyroidism in the infant.
Dosage and administration
Individual. The daily dose in terms of iodine for children is 50-100 mcg, for adolescents and adults - 100-200 mcg.
Side effects
Manifestations of iodism: swelling of the nasal mucosa, urticaria, angioedema, eosinophilia, shock; tachycardia, irritability, sleep disturbances, increased sweating, diarrhea (in patients over 40 years old) are also possible; in some cases, when used in doses exceeding 300-1000 mcg / day, hyperthyroidism may develop (especially in elderly patients, in the presence of nodular or diffuse toxic goiter); with high-dose therapy (more than 1 mg / day), goiter-induced iodine and, accordingly, hypothyroidism can develop.
Overdose
Symptoms of acute overdose: staining of the mucous membrane of the oral cavity in brown, rhinitis, bronchitis, gastroenteritis, swelling of the vocal cords, bleeding from the urinary tract, anuria, collapse (up to a fatal outcome). Treatment of acute overdose: washing the stomach with starch solution (until blue disappears staining solution) and 1% sodium thiosulfate solution, taking gruel from flour, corn, potato, rice or oat broth, symptomatic and supportive therapy.
Interaction with other drugs
With simultaneous high-dose therapy with iodine and potassium-sparing diuretics, hyperkalemia may develop, with lithium preparations - the development of goiter and hypothyroidism. Perchlorate and thiocyanate competitively inhibit the absorption of iodine by the thyroid gland, and TSH stimulates. Anti-thyroid drugs weaken the effect (mutually).
special instructions
During therapy, patients with renal insufficiency may develop hyperkalemia.