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Active ingredients
Benzocaine
Release form
Ointment
Composition
1 g contains: hydrocortisone acetate 5.58 mgframicetin sulfate 10 mg sodium heparin 100 MEesculozide 10 mg benzocaine (ethylaminobenzoate) 10 mg butamben (butylaminobenzoate) 10 mg Auxiliary substances: cholesterol, liquid paraffin, paraffin soft white, polysorbate, you need to give you, asphalt. polyethylene glycol) 4000, macrogol (polyethylene glycol) 1540.
Pharmacological effect
Combined medication for the treatment of hemorrhoids and other diseases of the anorectal zone. Hydrocortisone - glucocorticosteroid, has anti-inflammatory effect. Eliminates the signs and symptoms of inflammation, such as redness, swelling, pain, and others. Framycetin sulfate is a broad-spectrum antibiotic for topical use from the group of aminoglycosides. Framycetin is produced by some types of streptomycetes and was first isolated from Streptomyces lavendulae. In vitro experiments have shown that framycetin, like other aminoglycosides, affects protein synthesis by specifically and irreversibly inhibiting bacterial ribosome 30S subunits, resulting in an mRNA reading error, which means that framycetin has bactericidal activity against a number of gram-negative microorganisms (Escherichia coli, Klebsla pneumoniae, Aerobacter spp., Salmonella typhimurium, Salmonella paratyphi B, Shigella spp., Pasteurella multocida, Brucella spp., Proteus spp. (including Proteus vulgaris.), Pseudomonas spp. (including Pseudomonasasparis), Pseudomonas spp. (including Pseudomonasasparis), Pseudomonas spp. (including Pseudomonasaparis), including Pseudomonas spp. Serratia marcescens, Alcaligenes spp. And Bacillus subtilis), as well as gram-positive cocco in (Staphylococcus aureus, Staphylococcus epidermidis, Streptococcus pyogenes, Streptococcus faecalis, Streptococcus pneumoniae), and streptococci are less sensitive to framycetin. Framycetin does not act on pathogenic fungi, viruses, anaerobic flora. In clinical studies, the slow development of microorganism resistance to framycetin sulfate is shown. Sodium heparin (sodium salt of heparin) is an anticoagulant. Prevents thrombotic complications of hemorrhoids. Esculoside is a substance similar in its chemical structure to rutoside; reduces the increased fragility of capillaries. Benzocaine and butamben have a local anesthetic and antipruritic effect, reduce spasm of the anal sphincter. The effect of the drug appears a few minutes after application.
Pharmacokinetics
Data on the pharmacokinetics of the drug is not provided.
Indications
- internal and external hemorrhoids (acute and chronic); - prevention of recurrence of internal and external hemorrhoids; - perianal eczema; - proctitis; - acute and chronic fissures of the anus; - preoperative and postoperative treatment of patients with hemorrhoids; - postpartum hemorrhoids.
Contraindications
- tuberculosis, viral, fungal infection of the anorectal zone; - pregnancy; - lactation period (breastfeeding); - children's age (due to the lack of clinical data on the use of the drug). - hypersensitivity to the drug components; with hypertension, heart failure.
Use during pregnancy and lactation
The drug is contraindicated during pregnancy and lactation (breastfeeding).
Dosage and administration
Outwardly. A small amount of ointment should be applied with a finger on the areas of localization of itching or pain in the morning and evening, as well as after each bowel movement. deep enough into the rectum, and then, gently pressing the tube from the lower end, inject the ointment into the rectum, gradually removing the applicator. The ointment can be used alone or in combination with rectal capsules Proctosedyl M. Proctosedyl is used for e short time (no more than 7 days).
Side effects
Local reactions: a feeling of discomfort in the rectal area, burning in the rectum, dryness of the rectal mucosa. Other: secondary infection, allergic reactions and other hypersensitivity reactions. When using the drug in high doses and for a long time, there is a risk of systemic side effects associated with the presence of hydrocortisone.
Overdose
Data overdose is not provided.
Interaction with other drugs
Data on drug interactions drug Proctosedyl not provided.
special instructions
Do not use the drug after the expiration date.