Pyridoxine hydrochloride pills 10 mg N50 ozone
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Active ingredients
Pyridoxine
Release form
Pills
Composition
Pyridoxine hydrochloride 10 mg
Pharmacological effect
Vitamin B6. Plays an important role in the metabolism; necessary for the normal functioning of the central and peripheral nervous system. In the phosphorylated form, pyridoxine is a coenzyme of a large number of enzymes acting on the non-oxidative metabolism of amino acids (including on the processes of decarboxylation, transamination). Pyridoxine is involved in the metabolism of tryptophan, methionine, cysteine, glutamine and other amino acids. Plays an important role in histamine metabolism. Pyridoxine contributes to the normalization of lipid metabolism.
Pharmacokinetics
Metabolized in the liver to form pharmacologically active metabolites (pyridoxal phosphate and pyridoxamine phosphate). Distribution mainly in the muscles, liver and central nervous system. Penetrates through the placenta and into mother's milk. Excreted by the kidneys (with the / in the introduction of bile - 2%).
Indications
Treatment and prevention of clinical deficiency of vitamin B6.
Contraindications
Hypersensitivity to pyridoxine.
Use during pregnancy and lactation
Perhaps the use of pyridoxine during pregnancy and lactation (breastfeeding) according to indications.
Dosage and administration
For the treatment of vitamin B6 deficiency by adults inside - 80 mg 4 times / day. It is also possible in / m, subcutaneous or in / in the introduction of a daily dose of 50-150 mg. The duration of treatment is determined by the type and severity of the disease.; To prevent vitamin B6 deficiency, a dose of 40 mg / day is used.
Side effects
In some cases: allergic reactions, hypersecretion of hydrochloric acid.
Interaction with other drugs
The physiological function of vitamins B1 and B6 is the potentiation of each other's actions, manifested in a positive effect on the nervous, muscular and cardiovascular systems.; When used simultaneously with hormonal contraceptives, the concentration of pyridoxine in the blood plasma may increase; With simultaneous use with levodopa, the effects of levodopa are reduced or completely suppressed.; With simultaneous use with isonicotine hydrazide, penicillamine, cycloser otherwise, the effectiveness of pyridoxine may decrease.; With simultaneous use with phenytoin, phenobarbital, plasma concentrations of phenytoin and phenobarbital may decrease.
special instructions
With caution used in gastric ulcer and duodenal ulcer, coronary artery disease.; In severe lesions of the liver, pyridoxine in high doses can cause deterioration of its function.