Rengalin solution for oral administration 100 ml
Condition: New product
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Active ingredients
Antibodies to bradykinin + Antibodies to histamine + Antibodies to morphine
Release form
Solution
Composition
Antibodies to bradykinin affinity-purified * 0.006 g, antibodies to histamine, affine-purified * 0.006 g, antibodies to morphine refined * 0.006 g. Supplementary substances: isomalt, saccharin sodium, sodium cyclamate, anhydrous citric acid, magnesium stearate.
Pharmacological effect
It was experimentally shown that the components of the drug modify the activity of ligand-receptor interaction of endogenous regulators with the corresponding receptors: antibodies to morphine - with opiate receptors, antibodies to histamine - with H1-histamine receptors, antibodies to bradykinin - with B1-receptors of bradykinin, with combined use components leads to increased antitussive effect. In addition to the antitussive effect, the complex drug has anti-inflammatory, anti-edematous, antiallergic, antispasmodic (antibodies to histamine, antibodies to bradykinin) and analgesic action (antibodies to morphine) due to its constituent components. Due to the modification of histamine-dependent activation of the H1 receptor and bradykinin-dependent activation of the B2 receptor, the complex drug Rengalin selectively reduces the excitability of the cough center of the medulla oblongata and inhibits the central links of the cough reflex. Inhibiting the centers of pain sensitivity in the thalamus, blocks the transmission of pain impulses to the cerebral cortex. Inhibits the flow of pain impulses from the periphery due to a decrease in the release of tissue and plasma algogens (histamine, bradykinin, prostaglandins, etc.). Unlike narcotic analgesics, it does not cause respiratory depression, drug dependence, does not possess a narcotic and hypnotic effect. It relieves the manifestations of acute pharyngitis, laryngitis and bronchitis, reducing bronchospasm. Suppresses systemic and local symptoms of allergic reactions due to the effect on the synthesis and release of histamine and bradykinin from mast cells.
Pharmacokinetics
The sensitivity of modern physicochemical methods of analysis (gas-liquid chromatography, high-performance liquid chromatography, chromatography-mass spectrometry) does not allow to evaluate the content of ultra-low doses of antibodies in biological fluids, organs and tissues, which makes it impossible to study the pharmacokinetics of the drug Rengalin.
Indications
- acute and chronic diseases of the respiratory tract, accompanied by cough and bronchospasm; - productive and unproductive cough for influenza and acute respiratory viral infections, acute pharyngitis, laryngotracheitis, acute obstructive laryngitis, chronic bronchitis and other infectious-inflammatory and allergic diseases of the upper and lower respiratory tract.
Contraindications
- increased individual sensitivity to the components of the drug.; Rengalin is not recommended for use in children under the age of 3 years due to insufficient data on efficacy and safety.
Dosage and administration
Inside At one time - 1 tab. (keep in mouth until completely dissolved). Apply 1-2 pills 3 times a day outside the meal. Depending on the severity of the condition in the first three days, the frequency of administration can be increased up to 4-6 times per day.