Renipril pills 20 mg 20 pcs
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Release form
Pills
Composition
Enalapril maleate 20 mg
Pharmacological effect
Antihypertensive drug, ACE inhibitor. The mechanism of action of enalapril is associated with inhibition of ACE activity, which reduces the formation of angiotensin II, which contributes to the narrowing of blood vessels, and simultaneously activates the formation of kinins and prostacyclin, which have vasodilating action. Enalapril belongs to prodrugs, after its hydrolysis enalaprilat is formed in the body, which inhibits this enzyme. Enalapril also has some diuretic effect associated with moderate inhibition of aldosterone synthesis. Along with a decrease in blood pressure, the drug reduces the pre- and afterload on the myocardium in heart failure, improves blood circulation in the small circle and respiratory function, reduces resistance in the kidney vessels, which helps normalize blood circulation in them.
Indications
- various forms of arterial hypertension (including renovascular). - chronic heart failure (as part of combination therapy).
Contraindications
- angioedema associated with the use of ACE inhibitors (in history). - progressive azotemia in bilateral stenosis of the renal arteries or stenosis of the artery of a single kidney. - childhood . - pregnancy. - lactation (breastfeeding). - Hypersensitivity to enalapril and other components of the drug. - hypersensitivity to other ACE inhibitors.
Use during pregnancy and lactation
Renipril is contraindicated during pregnancy and lactation.
Dosage and administration
Renipril prescribed by mouth regardless of the meal. In the treatment of essential arterial hypertension, the initial dose of Renapril is 10-20 mg / day. In the future, the dose is selected individually. With moderate hypertension enough dose of 10 mg / day. The maximum daily dose is 80 mg. Renovascular hypertension Renipril prescribed in smaller doses. The initial dose is usually 5 mg / day, then the dose is selected individually. The maximum dose is 20 mg / day. In case of heart failure, Renipril is prescribed starting from 2.5 mg, then the dose is gradually increased to 10-20 mg (1-2 times / day). The duration of treatment depends on the effectiveness of the therapy.In all cases, with a too pronounced decrease in blood pressure, the dose of the drug is gradually reduced. The drug is used both in monotherapy, and in combination with other antihypertensive drugs. In patients with impaired renal function, a single dose should be reduced or intervals should be extended.
Side effects
From the side of the central nervous system and peripheral nervous system: 2-3% - headache, dizziness, fatigue. rarely (when used in high doses) - insomnia, nervousness, depression, imbalance, paresthesia, tinnitus. Since the cardiovascular system: less than 2% - arterial hypotension, fainting. rarely - arrhythmias, angina. On the part of the digestive system: less than 2% - nausea, diarrhea. in some cases - pancreatitis, liver failure, dyspepsia. Allergic reactions: less than 2% - skin rashes. in some cases - angioedema (face, larynx). On the part of the respiratory system: dry cough, shortness of breath. From laboratory parameters: less than 2% - proteinuria, hyperkalemia, increased activity of hepatic transaminases, increased bilirubin concentration in the blood, neutropenia. Other: rarely (when used in high doses) - glossitis, hair loss, hot flashes, impotence. in patients with autoimmune diseases - agranulocytosis. Renipril is generally well tolerated and in most cases does not cause adverse reactions requiring discontinuation of the drug.
special instructions
From the side of the central nervous system and peripheral nervous system: 2-3% - headache, dizziness, fatigue. rarely (when used in high doses) - insomnia, nervousness, depression, imbalance, paresthesia, tinnitus. Since the cardiovascular system: less than 2% - arterial hypotension, fainting. rarely - arrhythmias, angina. On the part of the digestive system: less than 2% - nausea, diarrhea. in some cases - pancreatitis, liver failure, dyspepsia. Allergic reactions: less than 2% - skin rashes. in some cases - angioedema (face, larynx). On the part of the respiratory system: dry cough, shortness of breath. From laboratory parameters: less than 2% - proteinuria, hyperkalemia, increased activity of hepatic transaminases, increased bilirubin concentration in the blood, neutropenia.Other: rarely (when used in high doses) - glossitis, hair loss, hot flashes, impotence. in patients with autoimmune diseases - agranulocytosis. Renipril is generally well tolerated and in most cases does not cause adverse reactions requiring discontinuation of the drug.