Salamol eco light breathing aerosol 100 mcg dose 200 doses
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Active ingredients
Salbutamol
Release form
Spray
Composition
1 dose of aerosol contains: Active substance: salbutamol sulfate 124 mcg, which corresponds to the content of salbutamol 100 mcg. Adjuvants: hydrofluoroalkane (HFA-134a) - 26.46 mg, ethanol 96% - 3.42 mg.
Pharmacological effect
Bronchodilator drug, selective β2-adrenoreceptor agonist. in therapeutic doses, the drug acts on β2-adrenergic receptors of the smooth muscles of the bronchi, providing a pronounced bronchodilator effect, prevents and stops bronchospasm, increases lung capacity. prevents the release of histamine, a slow-reacting substance from mast cells and neutrophil chemotactic factors. It causes a slight positive chrono-and inotropic effect on the myocardium, dilates the coronary arteries, practically does not reduce the adhesion. the effect of the drug begins 5 minutes after inhalation and lasts for 4-6 hours. It has a number of metabolic effects: it lowers plasma potassium ions, affects glycogenolysis and insulin secretion, has hyperglycemic (especially in patients with asthma) and lipolytic effect , increases the risk of acidosis.
Pharmacokinetics
Absorption, distribution, metabolismAfter inhalation administration, up to 21% of the dose enters the respiratory tract. The rest remains in the device or settles in the oropharynx and then swallowed. Part of the dose that enters the respiratory tract is absorbed by the tissues of the lungs, without being metabolized in the lungs, and enters the bloodstream. When released into the systemic circulation, salbutamol is partially metabolized in the liver and excreted mainly by the kidneys in unchanged form or in the form of phenol sulfate. plasma is 10%. Cmax in the blood plasma - 30 ng / ml. T1 / 2–3.7–5 h. Injection. Excreted mainly by the kidneys in unchanged form and as a conjugate. Most of the dose of salbutamol administered IV, orally or by inhalation, is eliminated within 72 hours.
Indications
Prevention and relief of bronchospasm in bronchial asthma, chronic obstructive pulmonary disease (COPD), chronic bronchitis, pulmonary emphysema.
Contraindications
Hypersensitivity to any component of the drug, cardiac arrhythmias (paroxysmal tachycardia, polytopic ventricular premature beats), myocarditis, heart defects, aortic stenosis, coronary heart disease, tachyarrhythmia, thyrotoxicosis, decompensated diabetes, glaucoma, epilepsy, pilotage treatment, a heart stroke, an epilepsy, epilepsy, epilepsy, epilepsy , pregnancy, simultaneous reception of non-selective beta-blockers, children under 2 years of age.
Precautionary measures
The drug should be kept out of the reach of children, protected from direct sunlight, at a temperature not exceeding 25 ° C; do not freeze.
Use during pregnancy and lactation
The drug is contraindicated for use in pregnancy. During lactation (breastfeeding) prescribed only in cases where the expected benefit to the mother outweighs any potential risk to the child.
Dosage and administration
Adults and children over 12 years: 100-200 mcg Salamol Eco Light Breath (1-2 inhalation doses) for stopping asthma attacks. To control the course of asthma of mild severity - 1-2 doses 1-4 times a day and moderate severity of the disease - in the same dosage in combination with other anti-asthma drugs. For the prevention of physical stress asthma - 20-30 minutes before the load of 1-2 doses per dose. Children from 2 to 12 years: with the development of an attack of bronchial asthma, as well as to prevent attacks of bronchial asthma associated with exposure to an allergen or caused by exercise, The recommended dose is 100–200 mcg (1 or 2 inhalations). The daily dose of Salamol Eco Light Breath should not exceed 800 mcg (8 inhalations).
Side effects
Salamol Eco Light Breath can cause finger tremor, which is a typical side effect for all agonists of b-2-adrenoreceptors. Headache, dizziness, irritability, anxiety, sleep disturbance, insomnia, expansion of peripheral vessels (flushing of the skin of the face), a slight compensatory increase in heart rate, increased blood pressure may be noted.Hypersensitivity reactions may develop (including angioedema, urticaria, erythema, nasal congestion, bronchospasm, hypotension and collapse); muscle cramps, nausea, vomiting, dyspepsia. Inhalation drugs can cause paradoxical bronchospasm. Inhalation drugs can cause irritation of the mucous membranes of the mouth and pharynx (pharyngitis), cough. Salbutamol therapy can cause hypokalemia, which can pose a serious danger to the patient, as well as reversible metabolic disorders, for example, an increase in glucose concentration in the blood. The drug can cause arousal and increased motor activity in children. Arrhythmias may occur (including atrial fibrillation, supraventricular tachycardia and extrasystole).
Overdose
Symptoms: nausea, vomiting, irritability, hallucinations, tachycardia, ventricular flutter, dilatation of peripheral vessels, decreased blood pressure, hypoxemia, acidosis, hypokalemia, hyperglycemia, muscle tremor, headache. Treatment: withdrawal of the drug, admission of cardio-selective activities. if necessary, conduct symptomatic therapy. If overdose is suspected, the level of serum potassium should be monitored.
Interaction with other drugs
Theophylline and other xanthines, while being used with salbutamol, increase the likelihood of developing tachyarrhythmias; and means for inhalation anesthesia, levodopa - severe ventricular arrhythmias. It is not recommended to use the drug Salamol Eco Light Breathing and non-selective beta-adrenergic blockers (such as propranolol) at the same time. MAO inhibitors and tricyclic antidepressants increase the effect of salbutamol and result in an effect of MAO and tricyclic antidepressants increase the effect of salbutamol and result in an effect of MAO and tricyclic antidepressants increase the effect of salbutamol and result in an open-joint inhibitor. the use of salbutamol enhances the action of drugs with a stimulating effect on the central nervous system, the side effects of thyroid hormones, cardiac glycosides. At the same time nomu use of salbutamol reduces the effectiveness of antihypertensive drugs, nitrates. With simultaneous use with xanthine derivatives, GCS, diuretics, hypokalemia may increase. Simultaneous administration with anticholinergic drugs (includinginhalation) may contribute to an increase in intraocular pressure.
special instructions
In patients with severe or unstable bronchial asthma, the use of bronchodilators should not be the main or only method of therapy. The patient should be warned about the need to consult a doctor if the use of the drug Salamol Eco Light Breathing in a standard dose becomes less effective or less prolonged (the drug should last at least 3 hours). Frequent use of salbutamol can lead to increased bronchospasm and various complications (up to sudden death), in connection with which between the next inhalation it is necessary to take breaks of several hours. Increasing the need for the use of inhaled beta2-adrenome ticks with a short duration of action for the control of asthma symptoms indicative of an exacerbation of the disease. In such cases, the patient’s treatment plan should be reviewed and the issue of administering or increasing the dose of inhaled or systemic corticosteroids should be decided. Beta2-adrenomimetic therapy can lead to hypokalemia. Particular caution is recommended when treating severe attacks of bronchial asthma, since in these cases hypokalemia may increase as a result of the simultaneous use of xanthine derivatives, GCS, diuretics, and also due to hypoxia. In such situations, it is necessary to control the level of potassium in the blood serum. A bottle of Salamol Eco Light Breath cannot be pierced, taken apart or thrown into the fire, even if it is empty. Like most other means for inhalation in aerosol packaging, Salamol Eco Light Breath may be less effective at low temperatures. When cooling the cartridge, it is recommended to get it out of the plastic case and warm it with your hands for a few minutes.