Sodium Fluoride Tablet 2,2mg N250
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Active ingredients
Sodium Fluoride
Release form
Pills
Composition
Sodium fluoride 2.2 mg
Pharmacological effect
Sodium fluoride is an anti-caries prophylactic (especially in children and adolescents). Fluorine ions directly affect the processes of mineralization of hard dental tissues during their development. Additional introduction of fluorine ensures the formation of the most stable form of apatites, fluorapatite, in the tissues of the teeth. In addition, fluoride helps to reduce cariogenic activity of plaque. It inhibits the formation of lactic acid from carbohydrates.
Pharmacokinetics
Ingestion absorption - 93-97%, TCmax - 4 hours. At any dose, 50% of the received fluoride accumulates in the hard tissues of the tooth and bone tissue. Accumulation in organs or soft tissues is not observed. Excreted by the kidneys (not involved in the formation of bone tissue fluoride).
Indications
- prevention of dental caries in children aged 2 to 14 years (if the concentration of fluoride in drinking water does not exceed 0.7 mg / l).
Contraindications
- hypersensitivity; - hypothyroidism; - peptic ulcer of the stomach and duodenum (in the acute stage); - liver and / or renal failure; - pregnancy; - lactation period; - children's age up to 2 years; - living in an area with sufficient fluorine content in water (above 0.7 mg / ml). Sodium fluoride lozenges for children Orange 1.1 mg contain aspartame - a source of phenylalanine. This drug should not be taken in patients with phenylketonuria. Sodium fluoride lozenges for children 2.2 mg contain lactose. This drug should not be taken in patients with rare congenital intolerance to galactose, lactase deficiency, or glucose-galactose malabsorption.
Use during pregnancy and lactation
Contraindicated in pregnancy and lactation
Dosage and administration
Children aged 2 to 6 years - 1 tablet (1.1 mg) 1 time per day. Children over 6 years old - 1 tablet (2.2 mg) or 2 pills (1.1 mg) 1 time per day. The drug is recommended to take at bedtime after brushing. The pill is kept in the mouth until completely absorbed. The duration of treatment is at least 250 days per year, annually up to 15 years of age. It is not recommended to use drugs containing calcium at the same time.
Side effects
Nausea, vomiting, loss of appetite, fatigue, headache, diarrhea, ossification of the attachment sites of tendons and ligaments, hypothyroidism (with prolonged use), allergic reactions, rhinitis, osinophilia, skin rash, fluorosis (violation of the process of formation and calcification of enamel, the appearance of yellow , brown spots, ischias, increased brittleness and abrasion of teeth).
Overdose
Symptoms: lacrimation, hypersalivation, nausea, loss of appetite, vomiting, diarrhea, abdominal pain, pain in the lower limbs, arthralgia, fatigue, miosis, blurred vision, weakness, myasthenia gravis, tremor, convulsions, fever, tachycardia, decreased arterial pressure, respiratory failure, respiratory arrest. Treatment: the introduction of large quantities of fluid and calcium (a solution of calcium gluconate or calcium lactate, milk) to precipitate fluorides; washing the stomach with acidified water or 1% solution of sodium chloride, the appointment of saline laxatives, in / in the introduction of electrolytes (20 ml of 10-20% solution of calcium gluconate), vitamins; symptomatic therapy, control of calcium concentration in the blood; hemodialysis.
Interaction with other drugs
The absorption of sodium fluoride reduces antacids (prematurely dissolve the shell); Antacids are recommended to be used no earlier than 2 hours before taking sodium fluoride. Vitamins A and D contribute to the development of ectopic calcification.
special instructions
Do not exceed the recommended dose and follow the instructions of the dentist. Make sure that the child does not receive fluoride in addition, while taking other drugs or nutritional supplements. Use in children under 6 years of age requires special monitoring. In order to avoid the development of fluorosis, it is advisable to regularly conduct a dental examination of the teeth in a child at least 1-2 times a year.