Stoptussin drops for oral administration 50 ml
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Active ingredients
Butamirate + Gvayfenezin
Release form
Drops
Composition
Gvayfenezin 100 mg 5 g, butamirata dihydrocitrate 4 mg 200 mg. Adjuvants: ethanol 96% - 300 mg, floral fragrance (alpine flowers) - 2 mg, purified water - 7 mg, polysorbate 80 - 1 mg, licorice extract liquid - 3 mg, propylene glycol - up to 1 ml.
Pharmacological effect
Combined drug that has mucolytic (expectorant) and antitussive effect. Butamirate dihydrocitrate has a peripheral local anesthetic effect on the sensitive nerve endings of the bronchial mucosa, which provides an antitussive effect. Gvayfenezin increases the secretion of bronchial glands and reduces the viscosity of mucus. The increase in secretion is due both to a direct effect on the bronchial glands — by stimulating secretion from the bronchial glands and removing acid glycoproteins from acinar cells, and by a reflex pathway, when the afferent parasympathetic fibers of the gastric mucosa are irritated and the respiratory center is inhibited. Increase the tone n. vagus stimulates the production of bronchial secretions. The mucus produced by the bronchial glands enhances the activity of the ciliary epithelium, and as a result, the evacuation of mucus from the bronchi and its coughing is facilitated.
Pharmacokinetics
Butamirata dihydrocitrate: When ingested butamirata dihydrocitrate quickly and completely absorbed from the gastrointestinal tract. Plasma protein binding is 94%. It is metabolized to form 2 metabolites, which also have antitussive action. T1 / 2 - 6 h. Metabolites are excreted mainly (90%) by the kidneys and only a small part through the intestines. Gvayfenezin: Gvayfenezin when taken orally is rapidly absorbed from the digestive tract. Plasma protein binding is negligible. Gvayfenezin is rapidly metabolized, with the formation of inactive metabolites, which are excreted by the kidneys. T1 / 2 - 1 h.
Indications
- dry irritating cough (including in infectious and inflammatory diseases of the upper and lower respiratory tract); - to relieve cough in the pre- and postoperative period.
Contraindications
- myasthenia; - children up to 6 months; - I trimester of pregnancy; - lactation period (breastfeeding); - hypersensitivity to the components of the drug.
Dosage and administration
The drug is taken after meals. The appropriate number of drops is dissolved in 100 ml of liquid (water, tea, fruit juice). The interval between doses should be 6-8 hours. Consuming large amounts of liquid during a course of treatment enhances its effectiveness. When used in children weighing less than 7 kg, a dose reduction is possible, because the child does not drink all 100 ml of the prepared mixture, however, the total concentration of the drug should not be exceeded. In the absence of a positive effect, consult a doctor. Instructions for using the syringe for dosing For simple and accurate dosing of the drug, you can use a syringe for dosing (if attached). The scale on the syringe shows the number of drops in a metered dose. 1. Unscrew the cap of the bottle (counterclockwise). 2. Place the syringe in the adapter on the neck of the bottle in an upright position. 3. The bottle with the syringe placed in it should be turned upside down. Tightly holding the syringe and pulling the piston, dial the required amount of the drug. 4. If you want to measure a dose of 40 drops, you should dial 10 + 30 drops. 5. Turn the vial back to its upright position. 6. Carefully remove the syringe with the drug from the vial adapter. 7. Dissolve the dose of the drug in water, tea or fruit juice. 8. Screw the bottle in (clockwise). 9. After use, rinse the syringe with warm water.