Tavegil Injection Ampoule 0.1% 2ml N5
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Active ingredients
Clemastine
Release form
Solution
Composition
Clemastine hydrofumarate 1.34 mg 2.68 mg, which corresponds to the content of clemastin 1 mg 2 mg. Auxiliary substances: sorbitol - 90 mg, ethanol 96% - 140 mg, propylene glycol - 600 mg, sodium citrate dihydrate - to pH 6.3, water d / and - to 2 ml.
Pharmacological effect
Blocker H1 - histamine receptors, a derivative of ethanolamine. It has a strong antihistaminic and antipruritic effect with rapid onset of action and a duration of 12 hours, prevents the development of vasodilation and smooth muscle contraction, induced gistaminom.Obladaya antiallergic action, reduces the permeability of blood vessels, capillaries, inhibits exudation and edema formation, reduces itching, has m-anticholinergic Effect.
Pharmacokinetics
Communication with plasma proteins is 95%. Two-phase elimination from plasma, corresponding to T1 / 2 is 3.6 ± 0.9 h and 37 ± 16 h. Clemastine undergoes significant metabolism in the liver. Metabolites are mainly (45-65%) excreted through the kidneys in the urine; unchanged active substance is found in urine only in trace amounts. During lactation, a small amount of clemastin can penetrate into breast milk.
Indications
- prevention or treatment of allergic and pseudo-allergic reactions (including with the introduction of contrast agents, blood transfusion, diagnostic use of histamine); - angioedema, anaphylactic or anaphylactoid shock (as an additional means).
Contraindications
- hypersensitivity; - pregnancy; - lactation period; - taking MAO inhibitors; - lower respiratory tract diseases (including bronchial asthma); - fructose intolerance; - children under 1 year of age. Intra-arterial administration of the drug is not permitted! in patients with stenosing gastric ulcer, pyloroduodenal obstruction, with bladder neck obstruction, and prostatic hypertrophy, accompanied by urinary retention, with increased intraocular pressure, hyperthyroidism, and heart diseases Normally the cardiovascular system, including hypertension.
Precautionary measures
Use in childrenContraindicated in children under 1 year. Children older than 1 year: 0.025 mg / kg / day i / m, divided into 2 injections.
Use during pregnancy and lactation
The use of the drug during pregnancy and during breastfeeding is contraindicated.
Dosage and administration
Adults: 2 mg (2 ml), that is, the contents of 1 ampoule, 2 times a day (morning and evening). For prophylactic purposes, the drug is administered intravenously in a jet stream slowly (over 2-3 minutes or more) at a dose of 2 mg immediately before the possible occurrence of an anaphylactic reaction or a reaction in response to the use of histamine. The solution of the drug can be further diluted with an isotonic solution of sodium chloride or 5% glucose solution in a ratio of 1: 5. Children: 0.025 mg / kg / day v / m, divided into 2 injections.
Side effects
The classification of the frequency of adverse reactions: very often (more than 1/10); often (more than 1/100, less than 1/10); infrequently (more than 1/1000, less than 1/100); rarely (more than 1/10 000, less than 1/1000); very rarely (less than 1/10 000). From the nervous system: often - increased fatigue, drowsiness, sedation, weakness, fatigue, lethargy, impaired coordination of movements; infrequently - dizziness; rarely - headache, tremor, stimulating effect. For the gastrointestinal tract: rarely - dyspepsia, nausea, vomiting, gastralgia, dry mouth; very rarely - constipation. From the sense organs: rarely - impaired visual perception, diplopia, acute labyrinthitis, tinnitus. From the kidneys and urinary tract: very rarely - frequent or difficult urination. From the respiratory system: rarely - bronchial thickening secret and difficulty in expectoration of sputum, feeling of pressure in the chest, respiratory failure, nasal congestion. From the cardiovascular system: rarely - reduction of blood pressure (more often in elderly patients), beats; very rarely - tachycardia. From the side of blood and blood-forming organs: rarely - hemolytic anemia, thrombocytopenia, agranulocytosis. From the side of skin and subcutaneous fatty tissue: rarely - skin rash. From the immune system: not often - photosensitization, shortness of breath; rarely, anaphylactic shock. If any of the side effects indicated in the instructions are exacerbated, or you notice any other side effects that are not listed in the instructions, tell your doctor.
Overdose
Symptoms An overdose of antihistamines can lead to both oppressive and stimulating effects on the central nervous system, more often seen in children.Phenomena of anticholinergic action may also develop: dry mouth, fixed pupil dilation, rush of blood to the upper half of the body, tachycardia, gastrointestinal disorders (nausea, epigastric pain, vomiting). Treatment. Symptomatic therapy is indicated.
Interaction with other drugs
Tavegil; enhances the action of drugs that depress the central nervous system (hypnotics, sedatives, anxiolytics), m-cholinoblockers, and also alcohol. Incompatible with simultaneous intake of MAO inhibitors.
special instructions
The effect on the ability to drive vehicles and control mechanismsKlemastin has a slight sedative effect (low to moderate in intensity), therefore, for those taking Tavegil; attention and speed of psychomotor reactions.