Tergynan pills vaginal 6 pieces
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Active ingredients
Ternidazole + Neomycin Sulfate
Release form
Pills
Composition
1 tablet contains: Active substance: ternidazole 200 mg, neomycin sulfate 100 mg (65,000 IU), nystatin 100,000 IU, prednisolone metasulfobenzoate sodium 4.7 mg, which corresponds to the content of prednisolone 3 mg. Substances: wheat starch - 264 mg, lactose monohydrate - qs up to 1.2 g, colloidal silicon dioxide - 6 mg, magnesium stearate - 10 mg, sodium carboxymethyl starch - 48 mg.
Pharmacological effect
Combined preparation for local use in gynecology. It has antimicrobial, anti-inflammatory, antiprotozoal, antifungal effects; ensures the integrity of the mucous membrane of the vagina and the constancy of rn. Ternidazole is an antifungal agent from the group of imidazole derivatives, reduces the synthesis of ergosterol (an integral part of the cell membrane), changes the structure and properties of the cell membrane. It has a trichomonacid effect, is also active against anaerobic bacteria, in particular Gardnerella spp. Neomycin is a broad-spectrum antibiotic from the group of aminoglycosides. It acts bactericidal against gram-positive (Staphylococcus, Streptococcus pneumoniae) and gram-negative (Escherichia coli, Shigella dysenteriae, Shigella flexneri, Shigella boydii, Shigella sonnei, Proteus spp.) Microorganisms; low active against Streptococcus spp. The resistance of microorganisms develops slowly and to a small extent. Nystatin is an antifungal antibiotic from the group of polyenes, highly effective against yeast-like fungi of the genus Candida, changes the permeability of cell membranes and slows their growth.
Pharmacokinetics
Data on the pharmacokinetics of the drug Tergynan not provided.
Indications
Treatment of vaginitis caused by susceptible microorganisms, including: - bacterial vaginitis; - trichomoniasis of the vagina; - vaginitis caused by fungi of the genus Candida; - mixed vaginitis. Prevention of urogenital infections / vaginitis, including: - before gynecological operations; - before childbirth or abortion; - before and after installation of the IUD; - before and after cervical diathermocoagulation; - before hysterography.
Contraindications
- Hypersensitivity to the drug.
Use during pregnancy and lactation
It is possible to use Terginan with the second trimester of pregnancy. Application of Terginan in the first trimester of pregnancy and lactation (breastfeeding) is possible only in cases when the expected benefit of therapy for the mother outweighs the potential risk to the fetus or infant.
Dosage and administration
For vaginal administration. 1 the tablet is inserted deep into the vagina in the supine bedtime position. Before the introduction of the tablet should be held in water for 20-30 seconds. After the injection, it is necessary to lie for 10-15 minutes. The average duration of the treatment course is 10 days; in case of confirmed mycosis, the duration of treatment can be extended to 20 days; The average duration of a prophylactic course is 6 days.
Side effects
Local reactions: rarely - burning sensation, itching and irritation in the vagina (especially at the beginning of therapy). Other: in some cases - allergic reactions.
Overdose
No data on overdose cases.
Interaction with other drugs
Drug interaction drug Tergynan not identified.
special instructions
In the case of treatment of vaginitis, trichomoniasis, simultaneous treatment of sexual partners is recommended. Treatment should not be stopped during menstruation.