Trichopol Tablets Vaginal 500mg N10
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Active ingredients
Metronidazole
Release form
Pills
Composition
1 tablet contains: Active substance: metronidazole 500 mg. Auxiliary substances: microcrystalline cellulose, povidone, crospovidone, colloidal silicon dioxide, stearic acid.
Pharmacological effect
Antiprotozoal drug with antibacterial activity for local use in gynecology. Refers to nitro-5-imidazole. The mechanism of action of metronidazole is the biochemical reduction of the 5-nitro group of metronidazole by intracellular transport proteins of anaerobic microorganisms and protozoa. The recovered 5-nitro group of metronidazole interacts with the microbial cell DNA, inhibiting the synthesis of their nucleic acids, which leads to the death of microorganisms. Metronidazole is an effective antimicrobial and antiprotozoal agent of a broad spectrum of action. It shows high activity against Trichomonas vaginalis, Gardnerella vaginalis, Giardia intestinalis, Entamoeba histolytica, Lamblia spp., As well as with respect to obligate anaerobes - Bacteroides spp. (Bacteroides fragilis, Bacteroides ovatus, Bacteroides distasonis, Bacteroides thetaiotaomicron, Bacteroides vulgatus), Fusobacterium spp., Veillonella spp., Prevotella spp. (Prevotella bivia, Prevotella buccae, Prevotella disiens) and some gram-positive microorganisms (Clostridium spp., Peptostreptococcus spp., Peptococcuc spp, Eubacterium spp., Mobiluncus spp.).
Pharmacokinetics
Metronidazole is well absorbed by intravaginal use. Biotransforming in the liver. Excreted by 40-70% (about 20% in unchanged form) by the kidneys.
Indications
For local treatment: - nonspecific vaginitis; - bacterial vaginosis; - trichomonas vaginitis.
Contraindications
- blood diseases; - leukopenia (including history); - loss of motor coordination; - organic lesions of the central nervous system (including epilepsy); - liver failure (for administration in high doses); - pregnancy (I trimester ); - lactation (breastfeeding); - hypersensitivity to metronidazole or other nitroimidazole derivatives.
Use during pregnancy and lactation
Metronidazole passes through the placenta, so do not prescribe the drug in the first trimester of pregnancy. In the future, you should use the drug only if the potential benefit to the mother outweighs the possible risk to the fetus. Metronidazole is excreted in breast milk. Breastfeeding during the period of use of the drug should be canceled. Breastfeeding should be resumed no earlier than 48 hours after the end of taking the drug.
Dosage and administration
When trichomonas vaginitis drug is prescribed 1 vaginal tablet per day for 7-10 days in combination with taking the drug metronidazole pills. For nonspecific vaginitis, bacterial vaginosis drug is prescribed 1 vaginal tablet per day for 7 days, if necessary in combination with taking the drug metronidazole pills. The treatment with metronidazole should not last more than 10 days and be repeated more than 2-3 times a year. The vaginal tablet should be removed from the contour packaging, moistened boiled cooled in ode and enter deep into the vagina.
Side effects
Local reactions: itching, burning, pain and irritation in the vagina; thick, white, mucous discharge from the vagina (odorless or with a faint odor), frequent urination; after discontinuation of the drug - the development of vaginal candidiasis. From the digestive system: nausea, change in taste, metallic taste in the mouth, dry mouth, decreased appetite, spastic abdominal pain, nausea, vomiting, constipation or diarrhea. On the side of the CNS: headache pain, dizziness. From the hemopoietic system: leukopenia or leukocytosis. Allergic reactions: urticaria, pruritus, rash.Other: rarely - urine stains in red-brown color due to the presence of water-soluble pigment forming I'm in the metabolism of metronidazole; burning sensation or irritation of the penis of the sexual partner.
Overdose
Data on drug overdose Trihopol not provided.
Interaction with other drugs
The drug is compatible with sulfonamides and antibiotics. Metronidazole causes ethanol intolerance, so alcohol should be avoided during treatment. Metronidazole should not be combined with disulfiram, since the interaction of these drugs may cause depression of consciousness, the development of mental disorders. When used simultaneously with indirect anticoagulants (m with warfarin-metronidazole enhances their action, which leads to an increase in prothrombin time. It is not recommended to use metronidazole combined with the non-depolarizing muscle relaxants (vecuronium bromide) .Pod influence of barbiturates may reduce the effectiveness of metronidazole due to acceleration of its metabolism in pecheni.Tsimetidin inhibits metabolism metronidazolewhich can lead to an increase in its concentration in the blood plasma and an increase in the risk of adverse reactions. If taken simultaneously with lithium preparations, its concentration in the blood plasma may be increased.
special instructions
Simultaneous treatment with metronidazole of a sexual partner is recommended, regardless of whether he has any manifestations of the disease. It is recommended to refrain from sexual contact with the drug during treatment. long-term treatment requires the control of a complete blood count. Metronidazole can cause treponema immobilization, which leads to false-positive results of the Nelson test (TPI). Effect on the ability to driving vehicles and controlling mechanisms. It is necessary to take into account the possibility of developing vertigo when prescribing the drug to patients engaged in potentially hazardous activities (especially drivers of vehicles).