Xylometazoline Solofarm nasal drops 0.1% 10ml
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Active ingredients
Xylometazoline
Release form
Drops
Composition
1 dose (140 mcl) of the preparation contains: Active substance: Xylometazoline hydrochloride 140 mcg Auxiliary substances: Benzalkonium chloride 14.0 mcg Disodium edetate (Trilon B) 70.0 mcg Sodium hydrophosphate dihydrate 280.0 mcg Sodium dihydrophosphate dihydrate 280.0 mcg Sodium Chloride 1020.0 mcg Water for Injection 38.75 mg
Pharmacological effect
Xylometazoline belongs to the group of local vasoconstrictor agents (decongestants) with α2-adrenomimetic action. It has a fast, pronounced and prolonged vasoconstrictor effect on the vessels of the mucous membrane of the nasal cavity, thus eliminating its swelling and hyperemia. Restores patency of the nasal passages, facilitates nasal breathing in rhinitis. In therapeutic concentrations does not irritate the mucous membrane of the nasal cavity, does not cause hyperemia. The action comes in a few minutes and lasts for 10-12 hours.
Pharmacokinetics
When applied topically, it is practically not absorbed, plasma concentrations are so small that they cannot be determined by modern analytical methods.
Indications
Acute respiratory diseases with rhinitis (runny nose), acute allergic rhinitis, pollinosis, sinusitis, eustachitis, otitis media (to reduce swelling of the nasopharyngeal mucosa). Preparing the patient for diagnostic manipulations in the nasal passages.
Contraindications
- hypersensitivity to the drug; - arterial hypertension; - tachycardia; - pronounced atherosclerosis; - glaucoma; - atrophic rhinitis; - thyrotoxicosis; - Surgery on the meninges (in history); - states after transfenoidal hypophysectomy; - children's age up to 2 years - for Xylometazoline - SOLOpharm, nasal spray dosed at 35 mcg / dose; - children's age up to 6 years - for Xylometazoline - SOLOpharm, nasal spray dosed at 140 mcg / dose; - pregnancy. Do not use in the treatment of monoamine oxidase inhibitors and tricyclic antidepressants (including a period of 14 days after their withdrawal).
Precautionary measures
Diabetes mellitus, prostatic hyperplasia, coronary heart disease (angina), pheochromocytoma, hyperthyroidism, lactation; with increased sensitivity to adrenergic drugs, accompanied by insomnia, dizziness, arrhythmia, tremor, increased blood pressure.
Use during pregnancy and lactation
Use of the drug during pregnancy is contraindicated. Perhaps the use for the treatment of nursing mothers as directed by the attending physician, if the expected therapeutic effect in the mother exceeds the risk of the development of possible side effects in the child.
Dosage and administration
Intranasal (in each nasal passage). The solution of the drug concentration of 0.1%: adults and children over 6 years, 2-3 drops in each nasal passage 2-3 times a day (if necessary, can be repeated); should not be used more than 3 times a day. The drug is used no more than 7 days.
Side effects
With frequent and / or long-term use - irritation and / or dryness of the mucous membrane of the nasopharynx, burning, tingling, sneezing, hypersecretion of the mucous membrane of the nasopharynx, hypersensitivity reactions, swelling of the mucous membrane of the nasal cavity, heartbeat, tachycardia, arrhythmia, increased blood pressure, headache , nausea, vomiting, insomnia, blurred vision, depression (with prolonged use of high doses). If any of the side effects indicated in the instruction are aggravated or you notice any other side effects that are not indicated in the instruction, inform your doctor.
Overdose
Strengthening of side effects (dose-dependent), decrease in body temperature, confusion. In case of accidental ingestion of the drug can cause: severe dizziness, increased sweating, headache, bradycardia, increased blood pressure, respiratory depression, coma and convulsions; after an increase in blood pressure, a sharp decrease can be observed. Treatment: symptomatic.
Interaction with other drugs
The simultaneous administration of xylometazoline with monoamine oxidase inhibitors (MAO) and tricyclic antidepressants can lead to an increase in blood pressure, therefore simultaneous administration of these drugs is not recommended.
special instructions
Before use, clean the nasal passages. Do not exceed the recommended dose and use the drug for a long time (more than 7 days) time. The use of the drug for more than 7 days may cause the effect of "rebound" (medical rhinitis). With prolonged use of the drug increases the risk of reactive hyperemia and atrophy of the nasal mucosa.Since the drug contains benzalkonium chloride, as a preservative, especially with prolonged use (more than 7 days), edema of the mucous membrane of the nasal cavity may develop. If you suspect a similar reaction (nasal congestion), it is necessary, if possible, to use a drug that does not contain preservatives. If such drugs are not available, you must use a different dosage form. In case of “catarrhal” diseases in cases when crusts form in the nose, it is preferable to prescribe it as a gel.