Zulbex pills enteric-coated 10mg N28
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Active ingredients
Rabeprazole
Release form
Pills
Composition
Rabeprazole sodium 10 mg, which corresponds to the content of rabeprazole 9.42 mg. Excipients: mannitol (E421) - 18.5 mg, magnesium light oxide - 30 mg, hyprolosis - 2.625 mg, low-level hyprolosis - 12.75 mg, magnesium stearate - 1.125 mg. The composition of the shell (bonding layer): ethyl cellulose - 0.44 mg, light magnesium oxide - 0.61 mg. The composition of the shell (enteric): hypromellose phthalate - 6.3 mg, diacetylated monoglycerides - 0.64 mg, talc - 0.59 mg, titanium dioxide (E171) - 0.32 mg, iron dye red oxide (E172) - 0.017 mg.
Indications
Pharmacokinetics
Contraindications
- peptic ulcer of the stomach and duodenum in the acute phase - gastroesophageal reflux disease (GERD): erosive reflux esophagitis (treatment), symptomatic treatment of GERD, including long-term maintenance therapy - Zollinger-Ellison syndrome - as part of complex therapy: Helicobacter pylori eradication in patients with gastric ulcer and duodenal ulcer or chronic gastritis - treatment and prevention of recurrence of peptic ulcer associated with Helicobacter pylori.
Dosage and administration
pharmachologic effect
Side effects
Tablets are taken orally, whole, without chewing or breaking. When gastric ulcer and duodenal ulcer in the acute phase of the drug is prescribed 20 mg 1 time per day, in the morning. In most patients, an active duodenal ulcer heals within 4 weeks. However, some patients may need another 4 weeks to fully heal the ulcer. Active benign gastric ulcer in most patients heals within 6 weeks. However, in a small number of patients, it may take another 6 weeks for complete healing. When gastroesophageal reflux disease (GERD): erosive reflux esophagitis (treatment), symptomatic treatment of GERD, the drug is prescribed 20 mg 1 time per day for 4 to 8 weeks. With long-term therapy, a maintenance dose of Zulbex can be used - 10–20 mg 1 time / day, depending on the patient’s response to treatment. With symptomatic treatment of GERD - 10 mg 1 time / day in patients without esophagitis. If, in 4 weeks, it is not possible to control the symptoms, an additional examination of the patient is necessary.After improving the condition of the patient, further control of the symptoms can be carried out with the intake of 10 mg 1 time / day, as required. With Zollinger-Ellison syndrome, the recommended starting dose for adults is 60 mg 1 time / day. The dose can be increased to 120 mg / day, depending on the individual needs of the patient. You can assign a daily dose of up to 100 mg 1 time / day. A dose of 120 mg may require multiple doses, 60 mg 2 times / day. Therapy is carried out as long as there are appropriate clinical indications. Eradication of Helicobacter pylori in patients with gastric ulcer and duodenal ulcer or chronic gastritis: patients with Helicobacter pylori should undergo eradication therapy. The following combinations of drugs for a course of 7 days are recommended: The drug Zulbex 20 mg 2 times / day + clarithromycin 500 mg 2 times / day and amoxicillin 1 g 2 times / day. In patients with impaired renal function and / or liver, dose adjustment of the drug Zulbex is not required. Due to the lack of data on the efficacy and safety of rabeprazole, the drug Zulbex is not used in children.
special instructions
Tablets are taken orally, whole, without chewing or breaking. When gastric ulcer and duodenal ulcer in the acute phase of the drug is prescribed 20 mg 1 time per day, in the morning. In most patients, an active duodenal ulcer heals within 4 weeks. However, some patients may need another 4 weeks to fully heal the ulcer. Active benign gastric ulcer in most patients heals within 6 weeks. However, in a small number of patients, it may take another 6 weeks for complete healing. When gastroesophageal reflux disease (GERD): erosive reflux esophagitis (treatment), symptomatic treatment of GERD, the drug is prescribed 20 mg 1 time per day for 4 to 8 weeks. With long-term therapy, a maintenance dose of Zulbex can be used - 10–20 mg 1 time / day, depending on the patient’s response to treatment. With symptomatic treatment of GERD - 10 mg 1 time / day in patients without esophagitis. If, in 4 weeks, it is not possible to control the symptoms, an additional examination of the patient is necessary. After improving the condition of the patient, further control of the symptoms can be carried out with the intake of 10 mg 1 time / day, as required.With Zollinger-Ellison syndrome, the recommended starting dose for adults is 60 mg 1 time / day. The dose can be increased to 120 mg / day, depending on the individual needs of the patient. You can assign a daily dose of up to 100 mg 1 time / day. A dose of 120 mg may require multiple doses, 60 mg 2 times / day. Therapy is carried out as long as there are appropriate clinical indications. Eradication of Helicobacter pylori in patients with gastric ulcer and duodenal ulcer or chronic gastritis: patients with Helicobacter pylori should undergo eradication therapy. The following combinations of drugs for a course of 7 days are recommended: The drug Zulbex 20 mg 2 times / day + clarithromycin 500 mg 2 times / day and amoxicillin 1 g 2 times / day. In patients with impaired renal function and / or liver, dose adjustment of the drug Zulbex is not required. Due to the lack of data on the efficacy and safety of rabeprazole, the drug Zulbex is not used in children.