Acyclovir cream for external use 5 g
Condition: New product
1000 Items
Rating:
Be the first to write a review!
More info
Active ingredients
Acyclovir
Release form
Cream
Composition
1 fl. contains extracts of chamomile pharmaceutical and calendula medicinal, aluminum aceto-tartrate solution, dragosanthol, purified water, propylene glycol, polysorbate 80, methylparaben, propylparaben, sodium hydroxide, xanthan gum
Pharmacological effect
Acyclovir is an antiviral drug from the group of synthetic analogs of acyclic purine nucleoside-deoxyguanidine, which is a component of DNA. ; Acyclovir has a high specificity for the Herpes simplex type 1 and type 2 virus; varicella-zoster virus (Varicella zoster); Epstein-Barr virus. Moderately active against the pathogen cytomegalovirus infection. ; Acyclovir penetrates directly into virus-infected cells. Cells infected with the virus produce viral thymidine kinase, which phosphorylates acyclovir to acyclovir triphosphate. The latter interacts with viral DNA polymerase, which is synthesized for new viruses. Thus, "defective" viral DNA is formed, which leads to the suppression of the replication of new generations of viruses.
Pharmacokinetics
When applying the cream on intact skin, the absorption is minimal; not detected in blood and urine. ; Affected skin: moderate absorption.
Indications
Herpes simplex types 1 and 2 infections of the skin, genital herpes, shingles, chicken pox
Contraindications
Hypersensitivity to acyclovir or drug adjuvant.
Use during pregnancy and lactation
Adequate and controlled clinical studies of the safety of the drug during pregnancy have not been conducted. ; Use during pregnancy is possible only when the intended benefit to the mother outweighs the potential risk to the fetus. ; During treatment, it is necessary to solve the issue of stopping breastfeeding.
Dosage and administration
Outwardly. The drug is applied to the damaged skin 5 times a day (every 4 hours) in a thin layer on the affected and bordering skin. The cream is applied with a cotton swab or with clean hands to avoid additional infection of the affected areas.Therapy should be continued until the crust forms on the vesicles, or until they completely heal. The duration of treatment is at least 5 days, maximum 10 days.
Side effects
Hyperemia, dryness, peeling of the skin; burning, inflammation in contact with mucous membranes. Perhaps the development of allergic dermatitis.
Interaction with other drugs
It is possible to enhance the effect while prescribing an immunostimulator.
special instructions
To achieve the maximum therapeutic effect, it is necessary to start using the drug as early as possible (at the first signs of the disease: burning, itching, tingling, feeling of tension and redness). The cream is not recommended to be applied on the mucous membranes of the mouth and eyes, as it is possible the development of pronounced local inflammation. ; Acyclovir does not prevent the transmission of herpes through sexual intercourse; therefore, during treatment, it is necessary to refrain from sexual intercourse, even in the absence of clinical manifestations. ;