Aevit Meligen capsules 200mg N10
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Active ingredients
Vitamin E + Retinol
The brand
Meligen
Composition
1 caps & # 945. -Tocopherol acetate 100 mg retinol palmitate 35 mg (100 IU).
Pharmacological effect
Pharmacokinetics
Indications
The combined drug, whose action is determined by the properties of its fat-soluble vitamins A and E. Retinol (vitamin A) is a necessary component for the normal function of the eye retina: binding to opsin (red pigment of the retina), forms the visual purple rhodopsin, which is necessary for the visual adaptation in the dark. Vitamin A is necessary for bone growth, normal reproductive function, embryonic development, for regulating the division and differentiation of the epithelium (increases reproduction of epithelial skin cells, rejuvenates the cell population, inhibits keratinization processes). Vitamin A is involved as a cofactor in various biochemical processes. The function & # 945. -Tocopherol (vitamin E) remains unclear until the end. As an antioxidant, inhibits the development of free radical reactions, prevents the formation of peroxides that damage cellular and subcellular membranes, which is important for the development of the body, the normal function of the nervous and muscular systems. Together with selenium inhibits the oxidation of unsaturated fatty acids (a component of the microsomal electron transfer system), prevents hemolysis of erythrocytes. It is a cofactor of some enzyme systems. Restores capillary blood circulation, normalizes capillary and tissue permeability, increases the resistance of tissues to hypoxia.
Contraindications
Inside, regardless of the meal, daily for 1 caps / day. V / m - 1 ml / day. The duration of treatment is 20-40 days with intervals of 3-6 months. Possible to repeat courses.
Use during pregnancy and lactation
In order to avoid the development of hypervitaminosis A and E, do not exceed the recommended doses. When using the drug, it is necessary to take into account the high content of vitamin A in it (100 thousand IU), and also that it is a curative and not a prophylactic drug. A diet with a high content of Se and sulfur-containing amino acids reduces the need for vitamin E.
Dosage and administration
Hypo-and avitaminosis A and E, as well as the state of increased body need for vitamins A and E and / or a reduction in their intake: gastrectomy, diarrhea, steatorrhea, celiac disease, Crohn's disease, malabsorption syndrome, chronic cholestasis, liver cirrhosis, biliary atresia pathways, obstructive jaundice, cystic fibrosis of the pancreas, tropical sprue, infectious diseases (including chronic and "colds"), hemeralopia, xerophthalmia, keratomalacia, inadequate and unbalanced nutrition (including parenteral nutrition), fast thinning, nicotine addiction, drug addiction, alcoholism, a state of prolonged stress, taking Kolestiramine, Colestipol, mineral oils, neomycin, iron-containing products, when prescribing a diet with an increased content of polyunsaturated fatty acids, hyperthyroidism, pregnancy (including multiple pregnancy), lactation period . Peripheral neuropathy, necrotizing myopathy, abetalipoproteinemia. Effectiveness is not proven - atherosclerotic changes of blood vessels, violations of tissue trophism, obliterating endarteritis.
Side effects
Retinol weakens the effect of calcium supplements, increases the risk of hypercalcemia. Kolestiramin, Kolestipol, mineral oils, neomycin reduce the absorption of vitamins A and E (you may need to increase their dose). Oral contraceptives increase plasma retinol concentration. Isotretinoin increases the risk of retinol intoxication. The simultaneous use of tetracycline and retinol in high doses (50 thousand units and above) increases the risk of developing intracranial hypertension. Tocopherol (vitamin E) enhances the effect of GCS, NSAIDs, antioxidants, increases efficiency and reduces the toxicity of vitamins A, D, cardiac glycosides. Prescribing high doses of vitamin E can cause a vitamin A deficiency in the body. Tocopherol (vitamin E) increases the effectiveness of antiepileptic drugs in patients with epilepsy (who have elevated blood lipid peroxidation products). The simultaneous use of vitamin E in a dose of more than 400 U / day with anticoagulants (coumarin and indandion derivatives) increases the risk of hypoprothrombinemia and bleeding. The use of high-dose iron supplements enhances the oxidative processes in the body, which increases the need for vitamin E.
special instructions
Retinol weakens the effect of calcium supplements, increases the risk of hypercalcemia.Kolestiramin, Kolestipol, mineral oils, neomycin reduce the absorption of vitamins A and E (you may need to increase their dose). Oral contraceptives increase plasma retinol concentration. Isotretinoin increases the risk of retinol intoxication. The simultaneous use of tetracycline and retinol in high doses (50 thousand units and above) increases the risk of developing intracranial hypertension. Tocopherol (vitamin E) enhances the effect of GCS, NSAIDs, antioxidants, increases efficiency and reduces the toxicity of vitamins A, D, cardiac glycosides. Prescribing high doses of vitamin E can cause a vitamin A deficiency in the body. Tocopherol (vitamin E) increases the effectiveness of antiepileptic drugs in patients with epilepsy (who have elevated blood lipid peroxidation products). The simultaneous use of vitamin E in a dose of more than 400 U / day with anticoagulants (coumarin and indandion derivatives) increases the risk of hypoprothrombinemia and bleeding. The use of high-dose iron supplements enhances the oxidative processes in the body, which increases the need for vitamin E.