More info
Description
Andipal, as an antispasmodic, is used in spasms of peripheral vessels and vessels of the brain. Reducing the OPSS, acting on arterioles, the drug reduces blood pressure, improves collateral circulation. The combination of myotropic type antispasmodics (Dibazol and papaverine hydrochloride) with analgin enhances the analgesic effect of the latter in headaches and migraines. The presence in the preparation of phenobarbital contributes to the manifestation of a sedative effect and enhance the action of other components.
Active ingredients
Bendazole + Metamizole Sodium + Papaverine + Phenobarbital
Release form
Pills
Composition
Bendazole 20 mg metamizole sodium 250 mg papaverine hydrochloride 20 mg phenobarbital 20 mg
Pharmacological effect
Antispasmodic, analgesic effect
Pharmacokinetics
Each of the components of Andipal has a certain effect on the body. Metamizole sodium - has analgesic and anti-inflammatory effect. Well and easily absorbed, quite quickly comes the effect of its use. Bendazole or Dibazol - is able to dilate blood vessels, relieve spasms and lower blood pressure. In addition, the drug has a stimulating effect on the function of the spinal cord. Dibazol is an immunostimulating drug. The main application - spasms in the organs of the gastrointestinal tract and blood vessels, the treatment of certain diseases of the nervous system. Papaverine hydrochloride - relieves spasm of internal organs, as well as blood vessels. Large doses of the drug may reduce the excitability of the heart muscle and slow intracardiac conduction. Phenobarbital - has a soporific effect. Also applies to antiepileptic drugs. In small doses, it has a sedative effect, in combination with antispasmodics and analgesics, it is used to treat spasms of the smooth muscles of the internal organs.
Indications
Pain syndrome associated with moderately pronounced spasms of peripheral vessels and brain vessels: mild forms of hypertension, migraine.
Contraindications
- increased sensitivity to the components that make up the drug; Deficiency of glucose-6-phosphate dehydrogenase; - violation of AV conduction; - heavy dysfunction of a liver and kidneys; - blood disorders; - myasthenia; porphyria; - pregnancy (I trimester); -breast-feeding.
Dosage and administration
Adults - 1-2 pills. 2-3 times a day. The course of treatment is 7–10 days.If treatment is ineffective, the drug should be replaced or combined with other drugs (to achieve the hypotensive effect).
Side effects
Sometimes nausea, constipation, allergic reactions (up to anaphylactic shock) occur. With prolonged use of the drug may inhibit the effect on the blood due to the presence of dipyrone (leukopenia, rarely - agranulocytosis, thrombocytopenia). Phenobarbital, present in the composition of the drug, can have a sedative effect, sometimes ataxia and depression may occur (especially in elderly and debilitated patients).
Overdose
Symptoms: in case of overdose, severe drowsiness, dizziness, collapse state occurs. Treatment: first aid - gastric lavage, taking activated carbon. Symptomatic therapy.
Interaction with other drugs
Pharmacological: combination with nitrates (Nitroglycerin, Nitrosorbide, Sustac, etc.), BPC (Nifedipine, Corinfar), amiodarone, beta-blockers (Anaprilin, metoprolol, oxprenolol, talinolol, etc.), ganglobloblokatoram, you can use the same pattern, if you are using ganglioblokator, melanoglobin, coronfar, etc. (Furosemide, Hypothiazide, etc.), myotropic antispasmodics (dipyridamole, aminophylline, etc.) enhances Andipal's hypotensive effect. The combined use of direct adrenergic (adrenaline, norepinephrine, etc.) and indirect (ephedrine) type of action, n- and m-, n-cholinomimetic (nicotine, acetylcholine, etc.), analeptics (camphor, Sulfocamphocaine, Cordiamine, bemegride, lobelin, cytisine, etc.), tonic remedies (ginseng root, extract of Eleutherococcus, rhodiola extract, etc.) and Andipal’s reduces the hypotensive effect of the latter. Pharmacokinetic: the combined use of activated carbon, astringents and coating agents reduces the absorption of the drug in the gastrointestinal tract.
special instructions
Care should be taken when working with mechanisms. With prolonged use, it is necessary to control the blood picture.