Anti-angina N12 pastille formula
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Active ingredients
Tetracaine + Chlorhexidine + Ascorbic Acid
Release form
Pastilles
Composition
Ascorbic acid 50 mg chlorhexidine diacetate 2 mgtetracain hydrochloride 200 μg
Pharmacological effect
The antibacterial effect of chlorhexidine is due to the nonspecific binding of phospholipids to bacterial cell membranes. Chlorhexidine can have a bactericidal and bacteriostatic effect, mainly against gram-positive bacteria and Candida albicans, and to a lesser extent, against gram-negative bacteria. Chlorhexidine is especially active against Streptococcus muians, Streptococcus salivarius, Escherichia coli, Selenomonas spp. and anaerobic bacteria. The drug is significantly less effective against microbial species such as the Streptococcus sanguis, Proteus, Pseudomonas, Klebsiella veillonella.Anestetik tetracaine provides lokal deystvie.Askorbinovaya acid is a cofactor in the synthesis of collagen and tissue regeneration, enhances immune responses and reduces the permeability of the capillaries, thereby, contributes reduction of inflammation and swelling of the mucous membranes of the oral cavity and pharynx.
Indications
- prevention and treatment of infectious and inflammatory diseases of the oral cavity and pharynx (stomatitis, gingivitis, tonsillitis, pharyngitis, periodontal disease, the initial stage of angina, the condition after tonsillectomy or extraction of a tooth, etc.).
Contraindications
- hypersensitivity to the components of the drug; - children's age up to 5 years; - I trimester of pregnancy. With caution: in the II and III trimesters of pregnancy as prescribed by the doctor, lactation, diabetes mellitus, glucose-6-phosphate dehydrogenase deficiency, hemochromatosis, sideroblastic anemia, thalassemia, hyperoxaluria, oxalosis and kidney disease.
Precautionary measures
During treatment, psoriasis may worsen. During pheochromocytoma, propranolol can only be used after taking an alpha blocker. After a long course of treatment, propranolol should be discontinued gradually, under the supervision of a physician. during anesthesia, you must stop taking propranolol or find a remedy for anesthesia with minimal negative inotropic effects.The impact on the ability to drive vehicles and control mechanisms of patients whose activities require increased attention, the question of the use of propranolol on an outpatient basis should be addressed only after evaluating the individual response of the patient.
Use during pregnancy and lactation
Contraindicated in the first trimester of pregnancy. With care in II and III trimesters, and also in the period of a lactation.
Dosage and administration
Locally. Keep in mouth until complete resorption. Adults and children from 15 years: 6 pills per day with an interval of 2 hours. Children from 5 to 10 years: 3 pills per day with an interval of 4 hours. Children from 10 to 15 years: 4 pills per day with an interval of 3 hours.
Side effects
Allergic reactions. Intensive consumption can cause damage to the tooth enamel.
Overdose
Overdose symptoms: dizziness, general weakness, cyanosis, agitation, anxiety, muscle tremor, respiratory failure, nausea, vomiting. Treatment: gastric lavage, the appointment of saline laxatives; symptomatic therapy.
Interaction with other drugs
Tetracaine reduces the antibacterial activity of sulfanilamide drugs. Vasoconstrictor agents lengthen the effect and reduce the toxicity of tetracaine. Ascorbic acid increases the concentration in the blood of benzylpenicillin and tetracyclines, increases the risk of crystalluria in the treatment of short-acting salicylates and sulfonamides, reduces the concentration of oral contraceptives in the blood.
special instructions
It is not recommended to use simultaneously with drugs for the treatment of oral cavity and pharynx, containing iodine (Lugol solution, povidone-iodine). Ascorbic acid, which is part of the preparation, may change the results of some laboratory tests, which should be reported during tests.