More info
Active ingredients
Bromhexine + Guaifenezin + Salbutamol
Release form
Pills
Composition
Salbutamol (as sulfate) 2 mg, bromhexine hydrochloride 8 mg guaifenesin 100 mg.Vspomogatelnye substances: calcium hydrogen phosphate, corn starch, methyl parahydroxybenzoate (methyl paraben), propyl parahydroxybenzoate (propylparaben), purified talc, colloidal silicon dioxide, magnesium stearate.
Pharmacological effect
Combined drug with bronchodilator, expectorant and mucolytic action. Salbutamol is a bronchodilator, stimulates β2-adrenergic receptors of the bronchi, blood vessels and myometrium. Prevents or eliminates bronchospasm, reduces resistance to the airways, increases lung capacity. It causes the expansion of the coronary arteries, does not reduce blood pressure. Bromhexine is a mucolytic agent, has an expectorant effect, improves the discharge of sputum. Guaifenesin is a mucolytic agent, reduces the surface tension of the structures of the bronchopulmonary apparatus, stimulates the secretory cells of the bronchial mucosa, produces neutral polysaccharides, depolymerizes the acid mucopolysaccharides, reduces the viscosity of sputum, activates the ciliary apparatus of the bronchi, facilitates the removal of sputum and promotes the transfer of unproductive coughs, clothsmiths, causes the removal of sputum, and facilitates the removal of sputum.
Pharmacokinetics
Salbutamol: Absorption and distribution: When ingestion absorption is high. Bioavailability of salbutamol when administered is about 50%. Eating reduces the rate of absorption, but does not affect bioavailability. Plasma protein binding - 10%. It penetrates the placental barrier. Metabolism and excretion: It is subjected to presystemic metabolism in the liver and in the intestinal wall; it is inactivated by phenol sulfotransferase to 4-o-sulfate ester. T1 / 2 - 3.8-6 hours. Excreted by the kidneys (69-90%), mainly as an inactive phenolsulfate metabolite (60%) for 72 hours and with bile (4%). Bromhexine: Absorption and distribution: When administered orally, almost completely (99%) is absorbed from the gastrointestinal tract within 30 minutes. Bioavailability is low (as it is exposed to the effect of the first passage through the liver). It penetrates the placental barrier and the BBB.Metabolism and excretion: In the liver it undergoes demethylation and oxidation, it is metabolized to pharmacologically active ambroxol. T1 / 2 - 15 h (due to slow reverse diffusion from tissues). Excreted by the kidneys. In chronic renal failure, excretion of metabolites is impaired. With repeated use may accumulate. Gvayfenezin: Absorption and distribution: Absorption from the gastrointestinal tract - fast (25-30 minutes after ingestion). Penetrates tissues containing acid mucopolysaccharides. Metabolism and excretion: Approximately 60% of the administered drug is metabolized in the liver. T1 / 2 - 1 h. It is excreted by the lungs (with sputum) and by the kidneys both unchanged and in the form of inactive metabolites.
Indications
As part of the combined treatment of acute and chronic broncho-pulmonary diseases, accompanied by the formation of difficult-to-discharge viscous secretions: - bronchial asthma — tracheobronchitis— obstructive bronchitis — pneumonia — emphysema — pertussis — pneumoconiosis — pulmonary tuberculosis.
Contraindications
- hypersensitivity to the components of the drug — pregnancy, lactation — tachyarrhythmia, myocarditis — heart defects — decompensated diabetes mellitus — thyrotoxicosis — glaucoma — hepatic or renal failure — peptic ulcer of the stomach and duodenum in an acute phase — gastric bleeding — an element of a stomach extoma- pills) - children's age up to 6 years (for the use of pills). With caution, the drug in the form of pills is prescribed to patients with diabetes, peptic ulcer disease eludka and duodenal ulcer in remission.
Dosage and administration
The drug is taken orally. Adults and children over 12 are prescribed 1 tab. 3 times / day or 10 ml of Ascoril syrup by the examiner (2 teaspoons) 3 times / day. Children aged 6 to 12 years - 1/2 or 1 tab. 3 times / day or 5-10 ml of syrup Ascoril the examiner (1-2 teaspoons) 3 times / day. Children under the age of 6 years old are recommended to use Ascoril syrup for 5 ml (1 teaspoon) 3 times / day.