Bacteriophage Klebsiel polyvalent 20ml N4
Condition: New product
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Release form
Composition
- Active substance: sterile mixture of purified filtrates of phagolysates Klebsiella pneumonia, Klebsiella ozaenae, Klebsiella rhinoscleromatis 10 ml.
- Excipients: 8-hydroxyquinoline sulfate monohydrate 0.0001 g / ml.
Pharmacological effect
The drug causes specific lysis of bacteria Klebsiella pneumoniae, Klebsiella ozaenae, Klebsiella rhinoscleromatis.
Indications
Treatment and prevention of diseases caused by the bacteria Klebsiella pneumoniae, Klebsiella ozaenae, Klebsiella rhinoscleromatis as part of complex therapy:
- Ozena, scleroma.
- Diseases of the gastrointestinal tract (gastroenterocolitis, cholecystitis, pancreatitis, intestinal dysbiosis).
- Inflammatory diseases of newborns and young children (gastroenterocolitis, intestinal dysbacteriosis, omphalitis, pemphigus, pyoderma, septicemia and septicopyemia of various localization).
- Surgical infections (suppuration of wounds, purulent skin lesions, burns, peritonitis, pleurisy, mastitis, osteomyelitis, abscess).
- Urogegatal infections (cystitis, pyelonephritis, urethritis, endometritis, vulvitis, bartholinitis, coleitis, salpingoophoritis).
- Purulent-inflammatory diseases of the ear, throat, nose, sinuses, mouth, pharynx, larynx, bronchi, lungs and pleura (otitis media, sore throat, pharyngitis, laryngitis, stomatitis, periodontitis, sinusitis, frontal sinusitis, bronchitis, pneumonia, pleurisy).
- Post-traumatic conjunctivitis, keratoconjunctivitis, purulent corneal ulcer and iridocyclitis.
- Prevention of nosocomial infections caused by Klebsiella.
An important condition for effective phage therapy is a preliminary determination of the pathogen sensitivity of the pathogen.
Contraindications
Hypersensitivity to the drug.
Use during pregnancy and lactation
The use of this drug during pregnancy and during breastfeeding is possible in the presence of infections caused by the phagnosensitive Klebsiella strains (as recommended by the doctor).
Dosage and administration
The drug is used for oral administration (through the mouth), in the form of enemas, applications, irrigation, the introduction into the cavity of wounds, vagina, uterus, nose, sinuses, and also drained cavities: abscesses, abdominal, pleural, bladder, renal pelvis.
Inside the drug is taken on an empty stomach 0.5-1 hour before meals.
Recommended dosage:
- The patient's age is 0-6 months - 5 doses per administration with the administration of the drug inside (ml) - 10 doses per administration with the introduction of the drug in enema (ml).
- The patient's age is 6-12 months - 10 doses per administration with the administration of the drug inside (ml) - 20 doses per administration with the introduction of the drug in enema (ml).
- The patient's age is from 1 year to 3 years - 15 doses per administration with the administration of the drug inside (ml) - 20-30 doses per administration with the introduction of the drug in enema (ml).
- The patient's age is from 3 to 8 years old - 20 doses per administration with the administration of the drug inside (ml) - 30-40 doses per administration with the introduction of the drug in enema (ml).
- The patient's age is 8 years and older - 20-30 doses per administration with the administration of the drug inside (ml) - 40-50 doses per administration with the introduction of the drug in enema (ml).
Treatment of purulent-inflammatory diseases with localized lesions should be carried out simultaneously both locally and taking the drug orally.
In the case of treatment of the cavity of a purulent focus with chemical antiseptics, it must be washed with sterile 0.9% sodium chloride solution before using the bacteriophage.
In the treatment of ozena and scleroma the drug is used for washing the nasal cavity and the mucous membrane of the upper respiratory tract, for introduction into the cavities of the nasal sinuses (for clinical reasons), as well as for the defeat of the pharynx, larynx, trachea in the form of inhalation (without heating and using ultrasound). The dose of the drug for the treatment of mucous membranes of the nose and upper respiratory tract 10-20 ml. After washing the mucous membranes, turunds moistened with the preparation are injected into each nasal passage by turns into the nasal cavity and left for 1 hour. The procedure is repeated 2-3 times a day for 20-40 days. Since ozena and scleroma are chronic diseases, in order to prevent exacerbations, it is recommended to conduct 20-40 days of treatment once a year according to the above scheme.
In the treatment of angina, pharyngitis, laryngitis the drug is used to rinse the mouth and pharynx Zraz per day for 10-20 ml, the course of treatment is 7-10 days.
In the treatment of bronchitis, pneumonia The drug is taken orally 3 times a day for 10-20 ml, and also used in the form of aerosols and inhalations (without heating and using ultrasound), the treatment course is 15-20 days.
In the treatment of otitis the drug is used to wash and inject into the cavity of the middle ear 2-5 ml 1-3 times a day. The course of treatment is 7-15 days.
In the treatment of inflammation of the sinuses the drug is used for washing the nasal cavity, nasopharynx, and sinuses in a dose of 5-10 ml and injecting 2-3 ml into the sinuses. The procedure is repeated daily once for 7-10 days. In addition, the drug is injected into the nasal cavity in the vice turunl, moistened with bacteriophage, in turn and in each nasal passage and left for 0.5-1 hours.The procedure is repeated 3 times a day, the course of treatment is 7-15 days.
In the treatment of stomatitis and chronic periodontitis the drug is used in the form of mouth rinses 3-4 times a day at a dose of 10-20 ml, as well as the introduction of turunds impregnated with Klebsiella bacteriophage into periodontal pockets for 5-10 minutes, the course of treatment is 7-10 days.
With conjunctivitis and keratoconjunctivitis the drug is used 2-3 drops 4-5 times a day, the course of treatment is 5-7 days; with purulent corneal ulcer - 4-5 drops per day for 7-10 days; with purulent iridocyclitis, 6–8 drops every 3 hours in combination with ingestion in therapeutic dosages for 7–10 days.
With abscesses after opening and removal of purulent contents, the drug is administered in an amount less than the volume of pus removed once a day, the course of treatment is 7-10 days.
With peritonitis and pleurisy the drug is introduced into the drained abdominal cavity and pleural cavity through the drainage tubes once daily 20-70 ml, the course of treatment is 10-15 days.
With osteomyelitis the drug is injected into the wound cavity through turunds, drainage in the amount of 10-30 ml daily once, a course of treatment is 15-20 days.
In the treatment of suppuration of wounds the drug is used in the form of irrigation, applications, dressings, introduction into the drainage in a dose of 5-50 ml, depending on the lesion at least once a day, course of treatment for 10-15 days.
In the treatment of purulent-inflammatory gynecological diseases (suppurations of wounds, endometritis, vulvitis, Bartholinitis, colpitis, salpingoophoritis) is used for irrigation, applications, injected into the cavity of wounds, vagina, uterus 5-20 ml once a day for 7-10 days.
With cystitis, pyelonephritis, urethritis The drug is taken orally at a therapeutic dose 3 times a day 1 hour before meals for 10-20 days. In that case, if the cavity of the bladder or the renal pelvis is drained, the drug is administered through a cystostom, or nephrostomy 1-3 times a day, 20-50 ml into the bladder and 5-7 ml into the renal pelvis, the course of treatment is 7-15 days.
In gastroenterocolitis, pancreatitis, cholecystitis, and intestinal dysbiosis bacteriophage is taken orally in age dosages 3 times a day 1 hour before meals for 7-15 days (for clinical reasons). When indomitable vomiting drug is used in the form of high enemas 2-3 times a day, 20-40 ml. For intestinal dysbiosis, the drug can be used with normoflora preparations.
For the prevention of nosocomial surgical infections The preparation is used for treatment of postoperative and freshly infected wounds in a dose of 5-50 ml, depending on the lesion, once a day for 5-7 days.
Use of the drug in children under 1 year (including premature babies).
With gastroenterocolitis, pneumonia and sepsis of newborns the drug is used, through the mouth 2-3 times a day, 3-5 ml for 30 minutes before feeding. In cases of indomitable vomiting, the drug is used in the form of high enemas (through a vapor tube or catheter) once daily in a dose of 5-10 ml. Perhaps a combination of rectal (in the form of high enemas) and oral administration of the drug: The course of treatment is 7-15 days- (for clinical reasons). In case of a relapsing course of the disease, repeated courses of treatment are possible.
In order to prevent the occurrence of nosocomial infections in newborns, the bacteriophage is used for epidemic indications within 3-5 ml 3 times a day 30 minutes before feeding during the entire period of hospital stay.
In the treatment of omphalitis, pyoderma, infected wounds bacteriophage is used in the form of applications of 5-10 ml 2-3 times a day (gauze moistened with bacteriophage and put on the wound or the affected skin area) for 7-15 days.
The use of the drug does not preclude the use of other antibacterial and anti-inflammatory drugs.
Side effects
Hypersensitivity to the drug.
Overdose
Interaction with other drugs
special instructions
Before using the bottle with a bacteriophage must be shaken and viewed. The drug should be clear and free of sediment.
Attention! In case of turbidity, do not use the drug!
Due to the content in the preparation of the nutrient medium in which bacteria can develop from the environment, causing clouding of the drug, it is necessary when opening the bottle to observe the following rules:
- Wash hands thoroughly.
- Treat cap with alcohol-containing solution.
- Remove the cap without opening the cap.
- Do not put the stopper on the inner surface of the table or other objects.
- Do not leave the bottle open.
- Open the vial only in the refrigerator.
When using small doses (2-8 drops), the drug should be taken with a sterile syringe in a volume of 0.5-1 ml.
The drug from the opened vial under the conditions of storage, the above rules and the absence of turbidity can be used during the entire shelf life.
Influence on ability to drive motor transport and control mechanisms
Missing.
Storage conditions
Store in accordance with SP 3.3.2.1248-03 in a dry place protected from light and out of reach of children at a temperature of from 2 to 8 ° C.