Cipromed eye drops 0.3% 5ml
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Active ingredients
Ciprofloxacin
Release form
Drops
Composition
1 ml of drops contains: Active substance: ciprofloxacin (in the form of hydrochloride) 3 mg. Auxiliary substances: benzalkonium chloride, sodium edetate, lactic acid, sodium chloride, sodium hydroxide, water d / and.
Pharmacological effect
An antibacterial drug from the group of fluoroquinolones for topical use in ophthalmology. has a broad spectrum of antibacterial action, has a bactericidal effect. the mechanism of action is associated with the ability to inhibit the enzyme dna-gyrase of bacteria, which leads to disruption of dna replication and synthesis of bacterial cellular proteins. Ciprofloxacin acts both on reproducing microorganisms and on those at rest. It is active against gram-negative microorganisms: escherichia coli, salmonella spp., shigella spp., proteus spp. (indole-positive and indole-negative strains), morganella morganii, citrobacter spp., klebsiella spp., enterobacter spp., vibrio spp., campyloididaidaididae, idenumia, providencia stuartii, haemophilus influenzae, pasteurella multoidaididaididaidaidaidaidaidaidaidaididaeididaeididaeididaeididaeidaeididaeididaeididaeididaeididaeididaeididaeididaeididaeididaeididaeididaeididaeididae. gardnerella spp. low toxicity.
Pharmacokinetics
Absorption When administered topically, ciprofloxacin penetrates well into eye tissue. After a single instillation, the concentration of ciprofloxacin in the moisture of the anterior chamber of the eye is reached after 10 minutes and is 100 μg / ml. Cmax in the moisture of the anterior chamber after 1 h is 190 μg / ml. After 2 h, the concentration of the drug begins to decrease, while its antibacterial effect in the tissues of the cornea lasts up to 6 h, in the anterior chamber moisture - up to 4 h. After instillation, systemic absorption of the drug is possible. During treatment for 7 days using 4 times / day both eyes have an average concentration of less than 2 ng / ml. Exposure When applied topically, T1 / 2 from plasma is 4-5 hours. The drug is excreted by the kidneys in unchanged form - up to 50%, and in the form of metabolites - up to 10%; through the intestines - about 15%. Some of the drug is excreted in breast milk.
Indications
Bacterial inflammatory diseases of the eye and its appendages: acute and subacute conjunctivitis; keratitis; anterior uveitis; blepharitis and other inflammatory diseases of the eyelids; dacryocystitis; prevention and treatment of infectious complications after injuries of the eye and its appendages and during operations on the eyeball.
Contraindications
Hypersensitivity to the components of the drug or to other quinolones, pregnancy, breastfeeding period and child up to 1 year
Precautionary measures
The drug should be stored out of the reach of children, protected from light at a temperature not exceeding 25 ° C; do not freeze.
Use during pregnancy and lactation
Cipromed is contraindicated for use during pregnancy. If you need to use the drug during lactation, breastfeeding should be stopped.
Dosage and administration
Locally. The drug is instilled 1-2 drops in the conjunctival sac. The frequency of installations depends on the severity of the inflammatory process. In acute bacterial conjunctivitis, simple, scaly and ulcerative blepharitis, Cypromed is prescribed 4 to 8 times a day, depending on the severity of the disease. The course of treatment is from 5 to 14 days. In keratitis, the drug is administered 1 drop at least 6 times a day, if there is a positive effect, the maximum course of treatment depending on the severity of the cornea is 2-4 weeks. more often - at least 8-12 times a day, 1 drop. The course of treatment depends on the course of the disease and usually takes about 2-3 weeks. In the case of anterior uveitis, the drug is instilled 8-12 times a day, 1 drop. In acute dacryocystitis and canaliculitis, Cypromed is prescribed 6-12 times a day, for chronic - 4-8 once a day, 1 drop. In case of injuries of the eye and its appendages for the prevention of secondary infection, Cipromed is prescribed for 1–2 weeks and 1 drop 4–8 times a day. To prevent inflammatory diseases after surgical interventions with perforation of the eyeball, Cipromed is prescribed 4- 6 times a day, 1 drop per the entire period of the postoperative period, usually from 5 days to 1 month.
Side effects
Immediately after the installation, there may be a slight burning sensation within 1-2 minutes, itching, soreness, hyperemia of the mucous membrane of the eye. Allergic reactions may develop. Eyelid edema, photophobia, lacrimation, foreign body sensation in the eyes, unpleasant taste in the mouth immediately after instillation, reduced visual acuity, the appearance of a white crystalline precipitate in patients with a corneal ulcer, keratitis, staining or corneal infiltration, development of superinfection.
Overdose
In case of accidental intake of Tsipromed inside, there are no specific symptoms.Possible: nausea, vomiting, diarrhea, headache, fainting, anxiety. Treatment: standard emergency measures, sufficient fluid intake in the body, creating an acidic urine reaction to prevent crystalluria.
Interaction with other drugs
Pharmaceutical interaction: Ciprofloxacin solution is incompatible with drugs with a pH value of 3-4, which are physically or chemically unstable.
special instructions
When wearing soft contact lenses, do not use Tsipromed eye drops, because The preservative in their composition can be deposited in soft contact lenses and adversely affect the eye tissue. Hard contact lenses should be removed before instillation of the drug and set them again after 15 minutes. When using other ophthalmic drugs, the interval between their administration should be at least 5 minutes. Impact on the ability to drive vehicles and control mechanisms psychomotor reactions, which can reduce the ability to engage in potentially hazardous activities that require increased attention (especially when neous use of alcohol).