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Active ingredients
Levamisole
Release form
Pills
Composition
Active ingredient: Levamisole. Concentration of active ingredient (mg): 150 mg
Pharmacological effect
The active ingredient of Decaris - levamisole is an anthelmintic agent. Acting on ganglion-like nematode formations, Decaris causes depolarizing neuromuscular paralysis of the muscle membrane of helminths, blocks succinate dehydrogenase, inhibits fumarate dehydrogenase, disrupting the course of the bioenergy processes of helminths. Thus, paralyzed nematodes are removed from the body by normal bowel motility within 24 hours after taking the drug.
Pharmacokinetics
Levamisole, when taken orally in a dose of 50 mg, is rapidly absorbed from the gastrointestinal tract. The maximum concentration in the blood plasma is determined, on average, in 1.5-2 hours after taking the drug. Levamisole is extensively metabolized in the liver, its main metabolites being p-hydroxy-levamisole and its glucuronide. The half-life from the body is 3-6 hours. Unchanged in urine is less than 5%, with feces less than 0.2% of the injected dose.
Indications
Helminth infestations of Ascaris lumbricoides, Necator Americanus and Ancylostoma duodenale.
Contraindications
Hypersensitivity to one of the components of the drug. drug-induced agranulocytosis (in history). children's age up to 3 years. lactation period. For pills 150 mg child age is Contraindications! Pregnancy Pregnant women should be prescribed only if the expected benefit exceeds the possible risk of using the drug. Lactation period To protect the newborn, you must decide whether to stop breastfeeding or stop taking the drug, depending on how much you need to take the drug for the mother. Take with caution when liver or kidney failure, inhibition of bone marrow hematopoiesis.
Precautionary measures
Decaris pills 150 mg should not be prescribed to children. During pregnancy, Decaris is prescribed only if the expected benefit to the mother exceeds the possible risk to the fetus. During and after taking Decaris for 24 hours, alcohol is not allowed.When driving a car or working in high-risk areas, it must be borne in mind that Decaris may cause transient, mild dizziness.
Use during pregnancy and lactation
Pregnancy. Pregnant drug prescribed only if the expected benefit exceeds the possible risk of the drug. Lactation period. To protect the newborn, you need to decide whether to stop breastfeeding or stop taking the drug, depending on how much you need to take the drug for the mother. To be taken with caution in case of hepatic and / or renal failure, inhibition of bone marrow hematopoiesis.
Dosage and administration
Tablets 50 mg: Children from 3 to 6 years (10-20 kg) - 25-50 mg (12-1 tablet). from 6 to 10 years (20-30 kg) 50-75 mg (1-1, 5 pills). from 10 to 14 years (30-40 kg) - 75-100 mg (1, 5-2 pills) once. The drug should be taken after a meal with a small amount of water in the evening. There is no need to take laxatives or a special diet. If necessary, the drug can be repeated after 7-14 days. Tablets 150 mg. Adults are prescribed once one pill 150 mg. The drug should be taken after a meal with a small amount of water in the evening. There is no need to take laxatives or a special diet. If necessary, the drug can be repeated after 7-14 days.
Side effects
Headache, insomnia, dizziness, feeling of heartbeat, convulsions, dyspepsia, such as nausea, vomiting, abdominal pain, diarrhea. There are reports of the development of phenomena from the central nervous system (encephalopathy) 2-5 weeks after taking the drug, as well as allergic reactions (skin rash), convulsions. In most patients, this phenomenon was reversible, and early use of glucocorticosteroid therapy improved the prognosis. The connection of these symptoms with taking Decaris is not completely convincing. With the use of large doses or with long-term therapy may be observed leukopenia, agranulocytosis, tremor
Overdose
Symptoms: When a large dose of levamisole (over 600 mg) was administered, the following signs of intoxication were described: nausea, vomiting, drowsiness, seizures, diarrhea, headache, dizziness and confusion. Treatment: In case of an accidental overdose - if it did not take a long time after taking the drug - you can wash the stomach.Monitoring of vital signs and symptomatic therapy is necessary. If there is evidence of anticholinesterase action, atropine may be administered.
Interaction with other drugs
At the same time taking the drug with alcohol disulfiram-like phenomena are observed. Care is required when applying Decaris with drugs that affect blood formation. While taking the drug with coumarin-like anticoagulants, the prothrombin time may be lengthened, so you need to adjust the dose of oral anticoagulant. Decaris increases the level of phenytoin in the blood, therefore, when applied simultaneously, it is necessary to control the level of phenytoin in the blood. Decaris cannot be used simultaneously with lipophilic drugs, such as carbon tetrachloride, tetrachlorethylene, henopodium oil, chloroform or ether, since its toxicity may increase.
special instructions
During and after taking the drug, within 24 hours you can not drink alcohol. It is not proved that levamisole, used as an anthelmintic agent, inhibits the nervous system.