Dipyridamol-OBL pills coated 75mg N40
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Active ingredients
Dipyridamole
Release form
Pills
Composition
Dipyridamole 75 mg
Pharmacological effect
Antiplatelet, angioprotector, immunomodulator. It has a inhibitory effect on platelet aggregation, improves microcirculation. It has a vasodilating effect, lowers the resistance of resistive coronary vessels (mainly arterioles), increases the volumetric rate of the coronary blood flow. Able to reduce perfusion of ischemic zones of the myocardium. The mechanism of action is not fully understood. It is believed that dipyridamole increases the content of adenosine (disrupting its reuptake), and also contributes to an increase in the concentration of cAMP due to inhibition of the PDE enzyme. As a pyrimidine derivative, dipyridamole is an interferon inducer and has a modulating effect on the functional activity of the interferon system, increases the decreased production of interferon alpha and interferon gamma leukocytes in vitro. Increases non-specific resistance to viral infections.
Indications
Treatment and prevention of cerebral circulatory disorders of ischemic type. encephalopathy . primary and secondary prevention of coronary artery disease, especially in case of intolerance to acetylsalicylic acid. prevention of arterial and venous thrombosis and treatment of their complications. prevention of thromboembolism after surgery for prosthetic heart valves. prevention of placental insufficiency in complicated pregnancy. violations of microcirculation of any type (as part of complex therapy). prevention and treatment of influenza, acute respiratory viral infections (as an interferon inducer and immunomodulator) - to receive the drug in a dose of 25 mg.
Contraindications
Hypersensitivity to the drug. acute myocardial infarction. unstable angina. common stenosing atherosclerosis of the coronary arteries. subaortic aortic stenosis. heart failure in the stage of decompensation. arterial hypotension. collapse . severe arterial hypertension. severe heart rhythm disorders. chronic obstructive pulmonary disease. chronic renal failure. liver failure . hemorrhagic diathesis. diseases with an increased risk of bleeding (including gastric ulcer and duodenal ulcer).
Use during pregnancy and lactation
In pregnancy and breastfeeding, it is possible if the intended benefit to the mother outweighs the potential risk to the fetus and baby (passes into the breast milk). Category of action on the fetus by the FDA - B.
Dosage and administration
The dose of the drug is selected depending on the severity of the disease and the individual response of the patient. When ischemic heart disease is recommended to take 75 mg 3 times / day. If necessary, the daily dose may be increased under the supervision of a physician. For the prevention and treatment of disorders of cerebral circulation, as well as for the prevention of prescribed 75 mg 3-6 times / day. The maximum daily dose is 450 mg. To reduce platelet aggregation, Curantil is prescribed in a dose of 75-225 mg / day in several doses. In severe cases, the dose may be increased to 600 mg / day. For the prevention of influenza and ARVI, especially during epidemics, Curantil N25 and Curantil 25 are prescribed 50 mg each (2 pills or 2 pills) / day in 1 administration. The drug is taken 1 time per week for 4-5 weeks. To prevent recurrence of acute respiratory viral infections in patients who frequently have respiratory viral infections, Curantil N25 and Curantil 25 are prescribed 100 mg / day (2 pills or 2 pills / day with an interval between doses of 2 hours). The drug is taken 1 time per week for 8-10 weeks. Tablets should be taken on an empty stomach, without breaking and not cracking, squeezed with a small amount of liquid. The duration of the course of treatment is determined by the doctor.