Dolobene gel for external use 50 g
Condition: New product
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Active ingredients
Sodium Heparin + Dexpanthenol + Dimethyl Sulfoxide
Release form
Gel
Composition
Gel for external use, composition (100 g): active substances: sodium heparin - 50000 ME; dexpanthenol - 2.5 g; 90% dimethyl sulfoxide - 16.66 g; (in terms of dry substance - 15 g); excipients: polyacrylic acid - 1–1.4 g; trometamol - 0.2–0.3 g; macrogol glyceryl hydroxystearate (cremophor CO455) - 1 g; isopropanol - 35 g; rosemary oil - 0.2 g; mountain pine oil - 0.25 g; citronella oil - 0.05 g; purified water - 42.023–42.913 g
Pharmacological effect
anti-inflammatory, antiedematous
Pharmacokinetics
DMSO; The physiological concentration of DMSO in normal blood plasma is 40 ng / ml. 6 hours after the application of the drug, Cmax in the blood plasma reaches 120 ng / ml and lasts up to 12 hours after application. After 60 h after application, the concentration of DMSO in the blood plasma reaches a physiological level of 40 ng / ml .; 12–25% of absorbed DMSO is excreted within the first 24 hours and 37–48% is excreted within 7 days unchanged or as a metabolite (dimethyl sulfone) via the kidneys. 3.5–6% of total DMSO is excreted through the lungs in the form of dimethyl sulfide 6–12 hours after the use of the drug .; When using 1 g of DMSO 3 times a day for 5 days, its average content at the site of application to the skin is 3 mg / g, the average content in the underlying muscle tissues and synovial membrane at the site of the synovial compound is 7–10 mcg / ml, in the synovial liquids - 0.8 mcg / g. The plasma concentration of DMSO is 0.5 μg / g. T1 / 2 DMSO is 11–14 h; Heparin; When used topically, heparin is absorbed slightly.; Dexpanthenol; When applied externally, dexpanthenol is transformed into pantothenic acid in the skin. Good absorption of dexpanthenol is confirmed experimentally.
Indications
swelling, hematomas and inflammation of the soft tissues, muscles, tendons, tendon sheaths; ; closed injuries, bruises; joint injuries with sprains and tendons; shoulder epicondylitis ("tennis elbow"), tendinitis (tendon inflammation), tendovaginitis (tendon sheath inflammation), bursitis (inflammation of the mucous membrane of the joint); periarthritis of the shoulder joint; acute neuralgia.
Contraindications
hypersensitivity to one of the components of the gel (active and / or excipients); ;bronchial asthma; severe violations of the liver, kidneys; marked disorders of the cardiovascular system; ;pregnancy; ; lactation period; ; age up to 5 years; open wounds at the site of application.
Use during pregnancy and lactation
Data overdose of the drug is not available.
Dosage and administration
Local .; Dolobene should be applied with a surface layer on the skin over the affected skin area 2–4 times a day .; When using the gel under the dressing, apply the drug and wait a few minutes for it to be absorbed by the skin and the isopropanol evaporated. You can then apply a hermetic bandage .; Dolobene can be used in iontophoresis. The drug is applied under the cathode .; Dolobene as a contact gel can be used in ultrasound therapy (phonophoresis). Gel active ingredients complement the therapeutic effects of ultrasound waves .; The duration of treatment depends on the severity of symptoms and the severity of the disease.
Side effects
Precautionary measures
Overdose
Interaction with other drugs
special instructions
Local skin reactions are possible (redness, itching, burning sensation at the site of gel application), which usually disappear during further treatment .; Due to the content of DMSO or other components of the drug, an allergic skin reaction is sometimes possible .; In rare cases, during the use of the drug, some patients may smell of garlic from the mouth. The smell is caused by dimethyl sulfide, which is a product of DMSO metabolism .; A change in taste is possible, disappearing within a few minutes after applying the gel .; In isolated cases, allergic reactions of immediate type may occur (urticaria, angioedema) .; Extremely rarely, when applying the drug to large areas of the body, nausea, diarrhea, difficulty breathing, headache, chills are possible.