More info
Active ingredients
Hemicellulase + Bile Components + Pancreatin
Release form
Dragee
Composition
; Pancreatin 192 mg, with enzymatic activity: lipase 6000 IU FIP, amylase 4500 IU FIP, proteases 300 IU FIP, hemicellulase 50 mg, bile components 25 mg. Adjuvants: sodium chloride. shell composition: tsellatsefat (cellulose acetate phthalate), ethyl vanillin, castor oil, sucrose, methyl parahydroxybenzoate (methyl paraben), propyl parahydroxybenzoate (propylparaben), gelatin, dextrose liquid (glucose liquid), talc, calcium carbonate, acacia gum, glycerol (glycerine), Macrogol ( polyethylene glycol 6000), titanium dioxide.
Pharmacological effect
Enzyme preparation. Compensates for the lack of exocrine pancreatic function due to pancreatin and the biliary function of the liver due to the bile component. Festal has a proteolytic, amylolytic and lipolytic effect. Enzymes included in pancreatin: amylase, lipase and protease facilitate the digestion of carbohydrates, fats and proteins, which contributes to their more complete absorption in the small intestine. The presence of bile acids in the Festal formulation provides additional opportunities for the correction of biliary insufficiency, which often accompanies chronic pancreatitis. Bile extract has a choleretic effect, facilitates the absorption of fats and fat-soluble vitamins A, E and K, promotes the secretion of lipase by the pancreas. Hemicellulase enzyme promotes the breakdown of plant fiber, which also improves the digestive processes, reduces the formation of gases in the intestine.
Pharmacokinetics
; Data on the pharmacokinetics of the drug is not provided.
Indications
Insufficiency of exocrine pancreatic function in chronic pancreatitis in combination with biliary insufficiency due to various pathological conditions, clinically manifested by impaired food digestion, flatulence, a tendency to constipation.; As part of combined therapy for: - diffuse liver diseases - alcoholic and toxic liver damage, liver cirrhosis - large losses of bile acids (in patients after cholecystectomy) - impaired circulation of bile acids, observed with dis kinesia of the biliary tract,dysbacteriosis, malabsorption is a violation of the neurohumoral regulation of the process of bile formation and bile secretion in chronic gastrointestinal diseases - chronic gastritis, chronic duodenitis, chronic cholecystitis. prolonged immobilization, sedentary lifestyle.; Preparation for X-ray and ultrasound of the abdominal organs.
Contraindications
- Hypersensitivity to the drug; - acute pancreatitis; - exacerbation of chronic pancreatitis; - liver failure; - hepatic coma or precoma; - hepatitis; - hyperbilirubinemia; - mechanical jaundice; - cholelithiasis; - empyema of the gallbladder; - intestinal obstruction; - tendency to diarrhea; - children's age up to 3 years (for this dosage form) .; With care: cystic fibrosis, pregnancy.
Use during pregnancy and lactation
With caution should use the drug during pregnancy. Data on the safety of the drug during lactation (breastfeeding) are not provided.
Dosage and administration
; The drug should be taken orally, without chewing, during or immediately after a meal, washed down with a small amount of liquid. Adults are prescribed 1-2 pills 3 times / day. Higher doses are prescribed by a doctor. The use of the drug in children as prescribed by a doctor. The duration of treatment can vary from several days (in case of disturbance of the digestive process due to errors in the diet) to several months or years (if necessary, continuous replacement therapy). Before radiological or ultrasound examination - 2 pills 2-3 times / day for 2-3 days before the study.
Side effects
; Allergic reactions: hyperemia of the skin, sneezing, lacrimation. On the part of the digestive system: nausea, diarrhea, abdominal pain (including intestinal colic). With prolonged use in high doses: possibly - hyperuricemia, hyperuricuria. When used in high doses in children: perhaps - perianal irritation, irritation of the oral mucosa.
Overdose
; Symptoms: hyperuricemia and hyperuricuria.Treatment: drug withdrawal and symptomatic therapy.
Interaction with other drugs
; With simultaneous use of the drug Festal increases the absorption of PASK, sulfonamides, antibiotics. Possible reduction in the absorption of iron preparations. The simultaneous use of antacids containing calcium carbonate and / or magnesium hydroxide, can lead to a decrease in the effectiveness of the drug Festal. Cimetidine enhances the effect of the drug.
special instructions
With caution should use the drug in patients with cystic fibrosis.