Glucose injection solution ampoules 40% 10ml N10
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Active ingredients
Dextrose
Composition
Dextrose 40 g per 100 ml
Pharmacological effect
Means for rehydration and detoxification. Isotonic dextrose solution (5%) is used to replenish the body with fluid. In addition, it is a source of valuable nutrient that is easily digested. With the metabolism of glucose in tissues a significant amount of energy is released, which is necessary for the vital activity of the body. With the on / in the introduction of hypertonic solutions (10%, 20%, 40%), the osmotic pressure of the blood increases, the flow of fluid from the tissues into the blood increases, metabolic processes increase, the antitoxic function of the liver improves, the contractile activity of the heart muscle increases, the vessels expand, and diuresis.
Pharmacokinetics
Dextrose, entering the tissue, is phosphorylated, turning into glucose-6-phosphate, which is actively involved in many parts of the body's metabolism. Excreted by the kidneys.
Indications
Replacing the lack of carbohydrates in the body. Correction of dehydration due to vomiting, diarrhea, in the postoperative period. Detoxification infusion therapy. Collapse, shock (as a component of various blood-substituting and anti-shock liquids). Used to prepare solutions of drugs for IV injection.
Contraindications
Hyperglycemia, diabetes mellitus, hyperlactacidemia, overhydration, postoperative disorders of glucose utilization; circulatory disorders threatening swelling of the brain and lungs; cerebral edema, pulmonary edema, acute left ventricular failure, hyperosmolar coma.
Use during pregnancy and lactation
Perhaps the use of dextrose during pregnancy and lactation (breastfeeding) according to indications.
Dosage and administration
Dextrose solutions injected into / in the drip. 5% solution: maximum up to 150 drops / min, the maximum daily dose for adults - 2 liters; 10% solution: up to a maximum of 60 drops / min, the maximum daily dose for adults - 500 ml; 20% solution: up to a maximum of 40 drops / min, the maximum daily dose for adults - 300 ml; 40% solution: up to a maximum of 30 drops / min, the maximum daily dose for adults is 250 ml.
Side effects
On the part of metabolism: possible violations of the ionic balance, hyperglycemia.Since the cardiovascular system: hypervolemia, acute left ventricular failure. Other: fever. Local reactions: rarely - local irritation, infection, thrombophlebitis.
special instructions
With caution, dextrose is prescribed for decompensated heart failure, chronic renal failure (oligoanuria), and hyponatremia. To increase the osmolarity of 5% dextrose solution can be combined with an isotonic solution of sodium chloride.