Gynoflor E vaginal pills 6 pieces
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Active ingredients
Lactobacillus acidophilic
Release form
Pills
Composition
1 tablet contains: Active substance: lactobacillus acidophilic (lyophilisate) 50 mg, estriol 30 mcg. Auxiliary substances: lactose monohydrate, microcrystalline cellulose, magnesium stearate, sodium carboxymethyl starch, sodium dihydrophosphate.
Pharmacological effect
Both active substance included in the preparation Gynoflor E, estriol and lactobacilli Lactobacillus acidophilus, are involved in maintaining normal physiological mechanism biotsinoza vlagalischa.Lactobacillus acidophilus - one of the dominant vaginal healthy woman microorganisms having antagonistic activity against pathogenic and opportunistic mikroorganizmov.Estriol - is a short-acting estrogen, has a protective trophic effect on the vaginal epithelium and has no systemic effect on the body of women . The proliferating mature epithelium of the vagina accumulates the glycogen necessary for the functioning of lactobacilli, which, in turn, produce lactic acid, maintaining the acidic environment of the vagina (pH 3.8-4.5), which creates unfavorable conditions for the colonization and development of pathogenic microorganisms. In addition to lactic acid, Lactobacillus acidophilus produce hydrogen peroxide and bacteriocins, which also inhibit the development of pathogenic and conditionally pathogenic microorganisms. The change in the physiological vaginal flora occurs due to various factors: local or systemic use of antibacterial drugs, including due to vaginal infections, systemic diseases, poor hygiene. In these cases, the amount of lactobacilli can be significantly reduced. Intravaginal application of Ginoflora E improves the condition of the vaginal epithelium and restores its normal flora. Lactose, which is contained in vaginal pills as a filler, can also be fermented by lactobacilli into lactic acid. The vaginal epithelium becomes thinner and can be damaged during hormonal disorders, and therefore Ginoflor E can be used in postmenopausal, reducing its local symptoms (itching, burning, dry vagina, pain during intercourse), contributing to the normalization of the epithelium of the vagina and urethra,reducing the frequency of dystrophic inflammatory conditions. In vitro, it is shown that Lactobacillus acidophilus for several hours leads to the necessary decrease in pH, and estriol, with a duration of treatment of 6-12 days, provides a proliferative trophic effect on the vaginal epithelium.
Pharmacokinetics
With the introduction of the drug into the vagina, lyophilized bacteria and estriol are released. The absorption of estriol from Gynoflora E has been studied in postmenopausal women. After repeated use of the drug, its plasma concentration corresponds to the concentration of endogenous unbound estriol. After the 12th day of vaginal pills use in the course of treatment with Ginoflor E (1 time per day), the maximum concentration of unbound estriol in the blood plasma does not differ from the initial one, which indicates the absence of systemic absorption. The use of the drug does not affect the concentration of estrone and estradiol in plasma blood, because estriol is the end product of their metabolism.
Indications
- restoration of the flora of Lactobacillus acidophilus after local and / or systemic treatment with antibiotics or other chemotherapeutic agents; - estrogen-dependent atrophic vaginitis in postmenopausal women, including in combination with hormone replacement therapy (HRT); - bacterial vaginosis.
Contraindications
- hypersensitivity to the drug or its components; - malignant estrogen-dependent neoplasms, including mammary glands, uterus and vagina (diagnosed, in history, and if they are suspected); - endometriosis (suspected or diagnosed); - vaginal bleeding of unknown etiology; - use in girls before the onset of sexual activity; - untreated endometrial hyperplasia.
Use during pregnancy and lactation
Use in the first trimester of pregnancy is undesirable. You can use the drug Gynoflor E in the II-III trimesters of pregnancy and lactation. Undesirable effects of lactobacilli and estriol on pregnancy and fetal / newborn state were not found. However, long-term clinical studies on the effect of estriol on the fetus has not been conducted.
Dosage and administration
Vaginal pills must be inserted deep into the vagina in the evening before bedtime, preferably in the supine position,Bending the legs at the knees slightly. To restore the flora of Lactobacillus acidophilus after local and / or systemic treatment with antibiotics or other chemotherapeutic agents, as well as in the treatment of bacterial vaginosis: 1-2 vaginal pills daily for 6-12 days. When treating estrogen-dependent atrophic vaginitis postmenopausal: 1 vaginal tablet daily for 6-12 days, then the maintenance dose is 1 vaginal tablet 1-2 times a week.
Side effects
Perhaps a burning sensation (heat) in the vagina, rarely redness and itching of the vulva and vagina.
Overdose
Overdose of the drug was not observed.
Interaction with other drugs
Lactobacillus acidophilus is susceptible to numerous antibacterial drugs (topical or systemic). Concomitant treatment with such agents may lead to a decrease in the effectiveness of Gynoflora E.
special instructions
Gynoflor E contains components that may not completely dissolve, residues of the vaginal pills can sometimes be found on underwear. This does not affect the effectiveness of the drug. In isolated cases, when the vagina is dry, the vaginal tablet may not dissolve. To prevent such cases, before the introduction of the tablet can be moistened with a small amount of ordinary water - this will contribute to its more rapid dissolution. Patients are advised to use pads. Influence on the ability to drive a car and other mechanisms Ginoflor E does not affect the ability to drive vehicles and mechanisms.