Kestine pills lyophilized 20mg N10
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Active ingredients
Ebastine
Release form
Uncoated Tablets
Composition
Ebastin 20 mg. Adjuvants: gelatin - 13.00 mg, mannitol - 9.76 mg, aspartame - 2.00 mg, mint flavor - 2.00 mg.
Pharmacological effect
Long-acting histamine H1 receptor blocker. Warns histamine-induced smooth muscle spasms and increased vascular permeability. After taking the drug inside the pronounced anti-allergic effect begins after 1 h and lasts for 48 hours. After a 5-day course of treatment with Kestine; 20mg lyophilized pills have antihistamine activity preserved for 72 hours due to the action of the active metabolite. With long-term administration, a high level of blockade of peripheral histamine H1-receptors remains without the development of tachyphylaxin. The drug does not have a pronounced anticholinergic and sedative effect. The effects of the drug Kestine are not marked; Tablets: freeze-dried pills of 20 mg per QT interval of an ECG at a dose of 100 mg, 5 times the recommended daily dose (20 mg).
Pharmacokinetics
AbsorptionAfter ingestion, it is rapidly absorbed and almost completely metabolized in the liver, turning into the active metabolite carbastin. After a single dose of 20 mg of the drug, the maximum concentration of carbastine in the blood plasma is reached after 1-3 hours and averages 157 ng / ml. Fatty food accelerates the absorption of carbastine (concentration in the blood increases by 50%) and presystemic metabolism (formation of carbastine). Distribution When taken daily, the equilibrium concentration is reached after 3-5 days and amounts to 130-160 ng / ml. Ebastine and carbastine plasma plasma protein binding is more than 95%. Carbastin T1 / 2 is 15 to 19 h. 66% of the drug is excreted as kidney conjugates. Pharmacokinetics in special clinical situations Elderly patients have pharmacokinetic parameters that do not change significantly. Renal failure T1 / 2 increases to 23-26 hours, and in liver failure - up to 27 hours, but the concentration of the drug does not exceed therapeutic values.
Indications
- treatment and prophylaxis (planned and emergency) of influenza, parainfluenza and other acute respiratory infections in order to alleviate the symptoms (as part of complex therapy); - treatment of inflammatory and rheumatic diseases accompanied by articular pain syndrome.
Contraindications
- Hypersensitivity to the components of the drug. Use during pregnancy and breastfeeding The question about the use of the drug Aflubin during pregnancy and lactation (breastfeeding) is decided by the doctor individually. Use in children The drug is used in children.
Precautionary measures
Use in children The drug is used in children.
Dosage and administration
In case of influenza and acute respiratory disease (1-2 day of illness), children under 1 year old are prescribed 1/2 tablet. or 1 cap., children 1-12 years old - 1/2 tab. or 5 cap., adults and adolescents - 1 tab. or 10 cap .. Reception frequency - no more than 3-8 times / day. In case of influenza and acute respiratory infections (advanced stage), children under 1 year old are prescribed 1/2 tablet. or 1 cap., children 1-12 years old - 1/2 tab. or 5 cap., adults and adolescents - 1 tab. or 10 drops .. Reception frequency - 3 times / day for 5-10 days. For routine prevention of influenza at the beginning of the cold season or 1 month prior to the annually expected peak in incidence, children under 1 year old are prescribed 1/2 tab. or 1 cap., children 1-12 years old - 1/2 tab. or 5 cap., adults and adolescents - 1 tab. or 10 cap .. Reception rate - 2 times / day. The course duration is 3 weeks. For emergency prophylaxis of influenza and acute respiratory infections immediately after contact with the diseased or after severe hypothermia, children under 1 year old are prescribed 1/2 tab. or 1 cap., children 1-12 years old - 1/2 tab. or 5 cap., adults and adolescents - 1 tab. or 10 cap .. Reception rate - 2 times / day. The duration of the course is 2 days. For the treatment of inflammatory and rheumatic diseases involving articular pain syndrome, children 1-12 years old - 1/2 tab. or 5 cap., adults and adolescents - 1 tab. or 10 cap. The frequency of admission - 3-8 times / day at the beginning of treatment (1-2 days), later - 3 times / day for 1 month. At the onset of the disease, as well as in cases requiring a quick relief of symptoms, the drug can be taken every 0.5 -1 h 8-10 cap., But not more than 8 times / day. After improvement, the drug is prescribed 3 times / day. The drug is taken 30 minutes before or 1 hour after a meal. Drops taken in pure form or diluted in 1 table. l water. Children under 1 year old drops diluted in 1 Chin. l water or breast milk. 1/2 tab. should also be dissolved in 1 tsp. l water or breast milk and give 1 cap. It is recommended to hold the drug in the mouth for some time before swallowing. The tablet should be kept under the tongue until completely absorbed.
Side effects
Seldom: increased salivation. The patient should be informed that you should see a doctor if other side effects occur.
Overdose
Overdose cases have not yet been reported.
Interaction with other drugs
Clinically significant drug interaction Aflubin with other drugs is not installed.
special instructions
Since the drug Aflubin in the form of homeopathic drops contains herbal natural ingredients, during storage a slight turbidity of the solution or a weakening of smell and taste may be observed, which does not reduce the effectiveness of the drug.