Lamisil spray for external use 15 ml
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Active ingredients
Terbinafin
Release form
Spray
Composition
1 g of the solution contains: The active substance is terbinafine hydrochloride 11.25 mg (corresponds to 10 mg of terbinafine base) Auxiliary substances: acrylic acid and octylacrylamide copolymer (Dermacryl 79), medium chain triglycerides, hyprolose, ethanol 96%.
Pharmacological effect
Antifungal drug for local use, with a wide range of antifungal activity. In low concentrations, terbinafine has a fungicidal effect against dermatophytes (Trychophyton rubrum, T.mentagrophytes, T.verrucosum, T.violaceum, T.tonsurans, Microsporum canis, Epidermophyton floccosum), mold (mainly C.albicans) and certain dimorphic fungi. Pityrosporum orbiculare). Activity against yeast fungi, depending on their species, can be fungicidal or fungistatic. Terbinafine in a specific way changes the early stage of sterol biosynthesis occurring in fungi. This leads to a deficiency of ergosterol and to the intracellular accumulation of squalene, which causes the death of the fungal cell. The action of terbinafine is carried out by inhibiting the enzyme squalene epoxidase, located on the cell membrane of the fungus. Terbinafine does not affect the cytochrome P450 system in humans and, accordingly, the metabolism of hormones or other drugs.
Pharmacokinetics
When applied topically, absorption - less than 5%, has a slight systemic effect.
Indications
Prevention and treatment of fungal infections of the skin, including foot mycoses (“fungus” of the foot), athlete's groin (tinea cruris), fungal lesions of smooth skin of the body (tinea corporis) caused by dermatophytes such as Trichophyton (including T. rubrum , T. mentagrophytes, T. verrucosum, T. violaceum), Microsporum canis and Epidermophyton floccosum. Pityriasis versicolor, caused by Pityrosporum orbiculare (also known as Malassezia furfur).
Contraindications
Hypersensitivity to terbinafine or to any of the inactive ingredients that make up the drug.
Precautionary measures
With caution: hepatic and / or renal failure, alcoholism, inhibition of bone marrow hematopoiesis, tumors, metabolic diseases, occlusive vascular diseases of the extremities, children's age (lack of sufficient clinical experience).
Use during pregnancy and lactation
In experimental studies, the teratogenic properties of terbinafine have not been identified. To date, no malformations have been reported with Lamisil.However, since the clinical experience with Lamisil in pregnant women is very limited, it should be used only if strictly indicated. Terbinafine is excreted in breast milk. However, in the case of nursing mother lamisil spray or solution, a small amount of the active substance is absorbed through the skin, therefore an adverse effect on the infant is unlikely.
Dosage and administration
Outwardly. Adults. Lamisil spray or solution can be applied 1 or 2 times a day, depending on the evidence. Before using the drug, it is necessary to thoroughly clean and dry the affected areas. The drug is sprayed (spray) or applied (solution) to the affected areas in an amount sufficient to thoroughly moisturize it, and, in addition, applied to the adjacent areas of both the affected and intact skin. In case of extensive fungal infections of the body, a spray of 30 ml is recommended. Duration of treatment and frequency of use of the drug: ringworm of the body, legs: 1 week; 1 time per day pediatric foot stop: 1 week; Once a day lichen colored: 1 week; 2 times a day The dosing regimen of Lamisil spray or solution in the elderly does not differ from the above. The use of Lamisil spray or solution in children. Experience with Lamisil spray or solution in children is limited, and therefore the use of the drug in children is not recommended.
Side effects
In places of application of the drug may appear redness, itching or burning. Allergic reactions.
Overdose
No cases of drug overdose have been reported. If, by chance, Lamisil Spray or Solution is ingested, you can expect the same side effects to occur as with an overdose of Lamisil pills (headache, nausea, epigastric pain, and dizziness). You should also consider the content in the preparation of ethyl alcohol (23.5%). Treatment: activated carbon, if necessary - symptomatic supportive therapy.
Interaction with other drugs
No drug interactions are known for Lamisil Spray or Solution.
special instructions
Reducing the severity of clinical manifestations is usually observed in the first days of treatment. In the case of irregular treatment or its premature termination, there is a risk of recurrence of the infection.In the event that after a week of treatment there are no signs of improvement, the diagnosis should be verified. Care should be taken when applying Lamisil on damaged skin, as alcohol can cause irritation. Lamisil spray or solution is for external use only. Avoid contact with eyes, as it may cause irritation. In case of accidental ingestion of the drug in the eyes, they should be immediately washed with running water, and in the case of persistent irritation, you should consult with your doctor. If the drug was accidentally introduced into the respiratory tract during inhalation, then, in the event of any symptoms, and especially with their persistent preservation, it is necessary to consult a doctor. With the development of allergic reactions necessary to cancel the drug.