Nazol Kids Spray Nasal 0.25% 10ml
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Description
Clear solution from colorless to light yellow color with a faint eucalyptus odor.
Active ingredients
Oxymetazoline
Release form
Spray
Composition
100 ml contain: active ingredient: phenylephrine hydrochloride 0.25 g, excipients: benzalkonium chloride 0.018 g, eucalyptol (cineol) 0.040 g, glycerol 4,000 g, macrogol 1500 1.500 g, sodium hydro-phosphate dihydrate 0.226 g, potassium dihydrogen phosphate 0.101 g , disodium edetate dihydrate 0.020 g, purified water 95.845 g. 1 dose contains: active ingredient: phenylephrine hydrochloride 0.125 mg, excipients: benzalkonium chloride 0.009 mg, eucalyptol (cineol) 0.02 mg, glycerol 2 mg, macrogol 1500 0.75 mg, sodium hydro¬phosphate dihydrate 0.113 mg, potassium dihydrophosphate 0.0505 mg, disodium ede m dihydrate 0.01 mg Purified water 47.9225 mg.
Pharmacological effect
Drug for symptomatic local treatment of rhinitis. Phenylephrine hydrochloride is an agonist of the alpha 1 adrenergic receptors (sympathomimetic) providing vasoconstrictive action due to stimulation of the alpha 1 receptors in the mucous membranes of the nasal cavity, reduces the swelling of mucous membranes and hyperemia of tissues, congestion in the mucosa of the nasal cavity, and also improves the permeability nasal airway. Restoration of airflow in the nasopharynx improves the patient's well-being and reduces the risk of possible complications caused by the stagnation of mucous secretions.
Pharmacokinetics
When applied topically, systemic absorption is low.
Indications
Symptomatic treatment: to facilitate breathing through the nose for colds, flu, hay fever or other allergic diseases of the upper respiratory tract, accompanied by acute rhinitis or sinusitis.
Contraindications
Hypersensitivity to the drug or its components, atrophic rhinitis, angle-closure glaucoma, severe atherosclerosis, conditions after transsphenoidal hypophysectomy, simultaneous use of monoamine oxidase inhibitors (including a period of 14 days after their withdrawal), children under 6 years of age, pregnancy, lactation period.
Precautionary measures
The drug should be used in patients with diseases of the cardiovascular system (arterial hypertension, coronary heart disease,chronic heart failure, tachycardia, arrhythmias), impaired carbohydrate metabolism (diabetes), with hyperthyroidism, pheochromocytoma, chronic renal failure, prostatic hyperplasia (urinary retention), with an increase in intraocular pressure, taking tricyclic antidepressants.
Use during pregnancy and lactation
Use during pregnancy and during breastfeeding is possible only in the case when the intended benefits to the mother outweigh the possible risk to the fetus or infant.
Dosage and administration
Intranasal. 1 dose contains 0,025 mg oxymetazoline hydrochloride. Adults and children over 12 years old - 2-3 doses in each nasal passage 2 times a day. Children from 6 to 12 years old - 1 dose in each nasal passage 2 times a day. Do not use the drug more than 2 times a day. Duration of treatment: It is not recommended to use the drug for more than 3 days. With frequent or long-term use of the drug, a feeling of difficulty in nasal breathing may appear again or worsen. If these symptoms appear, you should stop treatment and consult a doctor. When injecting, do not tilt the head backwards or spray in the prone position.
Side effects
Burning or dryness of the nasal mucosa, dryness in the mouth and throat, sneezing, an increase in the volume of secretions released from the nasal cavity. After the effect of the drug is passed, a strong feeling of nasal congestion (reactive hyperemia). Side effects caused by the systemic action of the drug: increased blood pressure, headache, dizziness, feeling of heartbeat, anxiety, nausea, insomnia. Benzalkoniya chloride, which is part of the drug, can cause irritation of the nasal mucosa. With prolonged use of the drug (more than 7 days) are possible: reactive hyperemia of the mucous membrane of the nasal cavity, atrophy of the mucous membrane of the nasal cavity, tachyphylaxis (a rapid decrease in therapeutic effect with repeated use).
Overdose
In case of overdose or accidental ingestion of the drug, the following symptoms may develop: nausea, vomiting, cyanosis, fever, tachycardia, arrhythmia, increased blood pressure, shortness of breath, mental disorders, depression of the central nervous system (drowsiness, decrease in body temperature, bradycardia, decrease in blood pressure, respiratory arrest and coma). Treatment is symptomatic; in case of accidental ingestion - gastric lavage, intake of activated carbon.
Interaction with other drugs
When used simultaneously with MAO inhibitors and tricyclic antidepressants, an increase in blood pressure may be observed. The drug slows down the absorption of local anesthetic drugs, lengthens their action. Co-administration of other vasoconstrictor drugs increases the risk of side effects.
special instructions
In the recommended dosage without consultation with the doctor, use no more than 3 days. Avoid contact with eyes. The drug has an effect on vision, possibly reducing the reaction rate. To avoid the spread of infection, you must use the drug individually. With prolonged use (more than one week), the symptoms of nasal congestion may resume. Influence on ability to drive machinery and other vehicles. During treatment, you should refrain from driving and practicing other potentially hazardous activities that require increased concentration or psychomotor speed, as the drug may cause dizziness and other side effects that may affect these abilities.
Storage conditions
At a temperature not higher than 25 ° С. Keep out of the reach of children.